Pick Topic
Review Topic
List Experts
Examine Expert
Save Expert
  Site Guide ··   
Prion Diseases HELP
Use this page to decide if "Prion Diseases" is the topic you want to explore.
Technical
Definition

A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES. (From Proc Natl Acad Sci USA 1998 Nov 10;95(23):13363-83)

Show Experts
Is a Disease or Syndrome
Alternatives
Broader Topics:
 
Related Topics:
  • Topics using similar words
Narrower Topics: