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Sleep Initiation and Maintenance Disorders: HELP
Articles from University of California Davis
Based on 11 articles published since 2008
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These are the 11 published articles about Sleep Initiation and Maintenance Disorders that originated from University of California Davis during 2008-2019.
 
+ Citations + Abstracts
1 Review Sleep disorders in patients with multiple sclerosis. 2010

Brass, Steven D / Duquette, Pierre / Proulx-Therrien, Joëlle / Auerbach, Sanford. ·Co-Director of Sleep Medicine, Department of Neurology, UC Davis School of Medicine, 4860 Y Street, Suite 0100, Sacramento, CA 95817, USA. steven.brass@ucdmc.ucdavis.edu ·Sleep Med Rev · Pubmed #19879170.

ABSTRACT: Patients with multiple sclerosis (MS) often have unrecognized sleep disorders at higher frequency than the general population. Sleep disorders such as sleep disordered breathing, insomnia, REM sleep behavior disorder, narcolepsy and restless legs syndrome have all been reported in the MS population. Notably, the most common symptom of MS is "fatigue," which itself has been correlated with sleep disturbances. Sleep disorders may impact the quality of life of the MS patient population. This paper reviews the association of sleep disorders with MS, and discusses the association of sleep disruption with MS fatigue.

2 Review Sleep in hospitalized medical patients, part 2: behavioral and pharmacological management of sleep disturbances. 2009

Young, Julie S / Bourgeois, James A / Hilty, Donald M / Hardin, Kimberly A. ·Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, California 95817, USA. julie.young@ucdmc.ucdavis.edu ·J Hosp Med · Pubmed #19140196.

ABSTRACT: BACKGROUND: As described in Part 1 of this article, multiple factors lead to disrupted sleep in hospitalized medical patients. Recognizing and addressing these factors can help clinicians more effectively manage patients' sleep complaints. METHODS: A PubMed search was conducted by cross-referencing the terms "sleep deprivation," "insomnia," and "sleep"; "hospitalized," "acutely ill," and "critically ill"; and "medication," "drugs," "hypnotics," "benzodiazepines," and "sedatives." The search was limited to English-language articles published between 1997 and 2008. Subsequent PubMed searches were performed to clarify the data described in the initial search. RESULTS: Few articles addressed the topic of the assessment and management of sleep problems in hospitalized medical patients. In Part 2, we propose an evaluation and treatment algorithm that includes recommendations regarding the use of nonpharmacologic and pharmacologic therapies as clinicians consider relevant clinical data. The algorithm is accompanied by 5 tables that include pertinent and practical information to assist clinicians as they manage their inpatients' sleep complaints. CONCLUSIONS: Assessment of a sleep complaint should include a review of factors that could exacerbate patients' sleep. The treatment could then focus on ameliorating these factors, and the judicious use of nonpharmacologic strategies and psychopharmacologic agents.

3 Review Sleep in hospitalized medical patients, part 1: factors affecting sleep. 2008

Young, Julie S / Bourgeois, James A / Hilty, Donald M / Hardin, Kimberly A. ·Department of Psychiatry and Behavioral Sciences, University of California-Davis, 2230 Stockton Boulevard, Sacramento, CA 95817, USA. julie.young@ucdmc.ucdavis.edu ·J Hosp Med · Pubmed #19084897.

ABSTRACT: BACKGROUND: Multiple factors lead to sleep disturbances in hospitalized medical patients. Inadequate sleep can lead to both psychological and physiological consequences. METHODS: A PubMed search was conducted using the terms: ("sleep deprivation," "sleep," or "insomnia") and ("hospitalized," "inpatient," "critical illness," or "acute illness") to review the published data on the topic of sleep in hospitalized medical patients. The search was limited to English-language articles published between 1997 and 2008. Subsequent PubMed searches were performed to clarify the data described in the initial search, including the terms "hospital noise," "hospital environment," "obstructive sleep apnea," and "heart failure." RESULTS: Few articles specifically addressed the topic of sleep in hospitalized medical patients. Data were limited to observational studies that included outcomes such as sleep complaints and staff logs of wakefulness and sleep. In Part 1, we review normal sleep architecture, and discuss how major medical disorders, the hospital environment, and medications can disrupt sleep during hospitalization. In Part 2, we will propose an evaluation and treatment algorithm to optimize sleep in hospitalized medical patients. CONCLUSIONS: Hospitalization may severely disrupt sleep, which can worsen pain, cardiorespiratory status, and the psychiatric health of acutely ill patients. Like vital signs, the patient sleep quality reveals much about patients' overall well-being, and should be a routine part of medical evaluation.

4 Article Sleep quality, duration, and breast cancer aggressiveness. 2017

Soucise, Allison / Vaughn, Caila / Thompson, Cheryl L / Millen, Amy E / Freudenheim, Jo L / Wactawski-Wende, Jean / Phipps, Amanda I / Hale, Lauren / Qi, Lihong / Ochs-Balcom, Heather M. ·Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA. · Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, OH, USA. · Department of Epidemiology, University of Washington, Seattle, WA, USA. · Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. · Program in Public Health and Department of Family, Population, and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA. · Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, CA, USA. · Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA. hmochs2@buffalo.edu. ·Breast Cancer Res Treat · Pubmed #28417334.

ABSTRACT: PURPOSE: Epidemiological studies suggest that short sleep duration and poor sleep quality may increase breast cancer risk. However, whether sleep is associated with breast tumor aggressiveness characteristics has largely been unexplored. METHODS: The study included 4171 non-Hispanic whites (NHW) and 235 African Americans (AA) diagnosed with incident, primary, invasive breast cancer in the Women's Health Initiative (WHI) Observational Study (1994-2013). We used logistic regression to examine the association of baseline sleep (sleep duration, sleep quality, WHI Insomnia Rating Scale) with tumor grade, stage, hormone receptor status, HER2 status. RESULTS: In NHW, women who reported 6 h of sleep/night were more likely to have tumors classified as regional/distant stage at diagnosis compared to women who slept 7-8 h/night (adjusted odds ratio (OR): 1.25, 95% confidence interval (CI): 1.05-1.48). AA women who reported their typical night's sleep as 'average quality' or 'restless or very restless sleep' were more likely to be diagnosed with triple-negative tumors than those who reported 'sound or restful' sleep (adjusted ORs: 2.91 (1.11, 7.63) and 3.74 (1.10, 12.77), respectively). CONCLUSIONS: Our findings provide indications that aspects of sleep (sleep duration and quality), partially modifiable health behaviors, may be associated with development of aggressive tumor characteristics in postmenopausal women. The role of these sleep attributes may differ for NHW and AA women; however, further study in robust, racial diverse samples is needed. This study provides evidence that facets of sleep behavior are associated with the development of aggressive tumor features and these associations differ by race.

5 Article Neural Reward Processing Mediates the Relationship between Insomnia Symptoms and Depression in Adolescence. 2016

Casement, Melynda D / Keenan, Kate E / Hipwell, Alison E / Guyer, Amanda E / Forbes, Erika E. ·University of Pittsburgh, Pittsburgh, PA. · University of Chicago, Chicago, IL. · University of California, Davis, Davis, CA. ·Sleep · Pubmed #26350468.

ABSTRACT: STUDY OBJECTIVES: Emerging evidence suggests that insomnia may disrupt reward-related brain function-a potentially important factor in the development of depressive disorder. Adolescence may be a period during which such disruption is especially problematic given the rise in the incidence of insomnia and ongoing development of neural systems that support reward processing. The present study uses longitudinal data to test the hypothesis that disruption of neural reward processing is a mechanism by which insomnia symptoms-including nocturnal insomnia symptoms (NIS) and nonrestorative sleep (NRS)-contribute to depressive symptoms in adolescent girls. METHOD: Participants were 123 adolescent girls and their caregivers from an ongoing longitudinal study of precursors to depression across adolescent development. NIS and NRS were assessed annually from ages 9 to 13 years. Girls completed a monetary reward task during a functional MRI scan at age 16 years. Depressive symptoms were assessed at ages 16 and 17 years. Multivariable regression tested the prospective associations between NIS and NRS, neural response during reward anticipation, and the mean number of depressive symptoms (omitting sleep problems). RESULTS: NRS, but not NIS, during early adolescence was positively associated with late adolescent dorsal medial prefrontal cortex (dmPFC) response to reward anticipation and depressive symptoms. DMPFC response mediated the relationship between early adolescent NRS and late adolescent depressive symptoms. CONCLUSIONS: These results suggest that NRS may contribute to depression by disrupting reward processing via altered activity in a region of prefrontal cortex involved in affective control. The results also support the mechanistic differentiation of NIS and NRS.

6 Article Sleep Disturbances and Glucose Metabolism in Older Adults: The Cardiovascular Health Study. 2015

Strand, Linn Beate / Carnethon, Mercedes / Biggs, Mary Lou / Djoussé, Luc / Kaplan, Robert C / Siscovick, David S / Robbins, John A / Redline, Susan / Patel, Sanjay R / Janszky, Imre / Mukamal, Kenneth J. ·Beth Israel Deaconess Medical Center, Department of Medicine, Boston, MA Department of Nutrition, Harvard School of Public Health, Boston, MA Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway linn.b.strand@ntnu.no. · Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL. · Department of Biostatistics, University of Washington, Seattle, WA. · Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, and Boston Veterans Healthcare, Boston, MA. · Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY. · Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA. · University of California, Davis, Sacramento, CA. · Beth Israel Deaconess Medical Center, Department of Medicine, Boston, MA Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA. · Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden. · Beth Israel Deaconess Medical Center, Department of Medicine, Boston, MA Department of Nutrition, Harvard School of Public Health, Boston, MA. ·Diabetes Care · Pubmed #26384390.

ABSTRACT: OBJECTIVE: We examined the associations of symptoms of sleep-disordered breathing (SDB), which was defined as loud snoring, stopping breathing for a while during sleep, and daytime sleepiness, and insomnia with glucose metabolism and incident type 2 diabetes in older adults. RESEARCH DESIGN AND METHODS: Between 1989 and 1993, the Cardiovascular Health Study recruited 5,888 participants ≥65 years of age from four U.S. communities. Participants reported SDB and insomnia symptoms yearly through 1989-1994. In 1989-1990, participants underwent an oral glucose tolerance test, from which insulin secretion and insulin sensitivity were estimated. Fasting glucose levels were measured in 1989-1990 and again in 1992-1993, 1994-1995, 1996-1997, and 1998-1999, and medication use was ascertained yearly. We determined the cross-sectional associations of sleep symptoms with fasting glucose levels, 2-h glucose levels, insulin sensitivity, and insulin secretion using generalized estimated equations and linear regression models. We determined the associations of updated and averaged sleep symptoms with incident diabetes in Cox proportional hazards models. We adjusted for sociodemographics, lifestyle factors, and medical history. RESULTS: Observed apnea, snoring, and daytime sleepiness were associated with higher fasting glucose levels, higher 2-h glucose levels, lower insulin sensitivity, and higher insulin secretion. The risk of the development of type 2 diabetes was positively associated with observed apnea (hazard ratio [HR] 1.84 [95% CI 1.19-2.86]), snoring (HR 1.27 [95% CI 0.95-1.71]), and daytime sleepiness (HR 1.54 [95% CI 1.13-2.12]). In contrast, we did not find consistent associations between insomnia symptoms and glucose metabolism or incident type 2 diabetes. CONCLUSIONS: Easily collected symptoms of SDB are strongly associated with insulin resistance and the incidence of type 2 diabetes in older adults. Monitoring glucose metabolism in such patients may prove useful in identifying candidates for lifestyle or pharmacological therapy. Further studies are needed to determine whether insomnia symptoms affect the risk of diabetes in younger adults.

7 Article Vitamin D and actigraphic sleep outcomes in older community-dwelling men: the MrOS sleep study. 2015

Massa, Jennifer / Stone, Katie L / Wei, Esther K / Harrison, Stephanie L / Barrett-Connor, Elizabeth / Lane, Nancy E / Paudel, Misti / Redline, Susan / Ancoli-Israel, Sonia / Orwoll, Eric / Schernhammer, Eva. ·Department of Nutrition, Harvard School of Public Health, Boston, MA. · California Pacific Medical Center Research Institute, San Francisco, CA, for the Osteoporotic Fractures in Men (MrOS) Study Group. · Department of Family and Preventive Medicine, University California San Diego, La Jolla, CA. · Department of Medicine, University of California at San Diego, La Jolla, CA. · Department of Medicine, University of California at Davis School of Medicine, Sacramento, CA. · Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN. · Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. · Departments of Psychiatry and Medicine, University of California, San Diego, CA. · Department of Veterans Affairs San Diego Center of Excellence for Stress and Mental Health (CESAMH), San Diego, CA. · Oregon Clinical and Translational Research Institute and School of Medicine, Oregon Health and Science University, Portland, OR. · Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. · Department of Epidemiology, Harvard School of Public Health, Boston, MA. ·Sleep · Pubmed #25581929.

ABSTRACT: STUDY OBJECTIVES: Maintaining adequate serum levels of vitamin D may be important for sleep duration and quality; however, these associations are not well understood. We examined whether levels of serum 25(OH)D are associated with objective measures of sleep in older men. SETTING AND PARTICIPANTS: Cross-sectional study within a large cohort of community-dwelling older men, the MrOS study. INTERVENTIONS: Among 3,048 men age 68 years or older, we measured total serum vitamin D. Objective estimates of nightly total sleep time, sleep efficiency, and wake time after sleep onset (WASO) were obtained using wrist actigraphy worn for an average of 5 consecutive 24-h periods. RESULTS: 16.4% of this study population had low levels of vitamin D (< 20.3 ng/mL 25(OH)D). Lower serum vitamin D levels were associated with a higher odds of short (< 5 h) sleep duration, (odds ratio [OR] for the highest (≥ 40.06 ng/mL) versus lowest (< 20.3 ng/mL) quartile of 25(OH)D, 2.15; 95 % confidence interval (CI), 1.21-3.79; Ptrend = 0.004) as well as increased odds of actigraphy-measured sleep efficiency of less than 70% (OR, 1.45; 95% CI, 0.97-2.18; Ptrend = 0.004), after controlling for age, clinic, season, comorbidities, body mass index, and physical and cognitive function. Lower vitamin D levels were also associated with increased WASO in age-adjusted, but not multivariable adjusted models. CONCLUSIONS: Among older men, low levels of total serum 25(OH)D are associated with poorer sleep including short sleep duration and lower sleep efficiency. These findings, if confirmed by others, suggest a potential role for vitamin D in maintaining healthy sleep.

8 Article Efficacy and safety of nonbenzodiazepine hypnotics for chronic insomnia in patients with bipolar disorder. 2011

Schaffer, Charles B / Schaffer, Linda C / Miller, Amber R / Hang, Evelyn / Nordahl, Thomas E. ·Department of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, CA, USA. schafferpsych@sbcglobal.net ·J Affect Disord · Pubmed #20701978.

ABSTRACT: BACKGROUND: Insomnia in patients with bipolar disorder (BD) can cause distress, daytime dysfunction, cognitive impairment, worsening of hypomanic/manic symptoms and increased suicide risk. Physicians often prescribe hypnotics for BD patients with insomnia although no hypnotic has a specific FDA indication for this use. In this study, the patterns of use, efficacy and safety of five nonbenzodiazepine hypnotics (NBZHs) were assessed in a large group of outpatients with BD. METHOD: A chart review was performed for all older adolescents and adult BD outpatients in a private outpatient clinic. Clinical data was collected for any patient who had ever been prescribed a NBZH for insomnia and included successful current use, past unsuccessful treatments, side effects, duration of use, concurrent psychiatric medications, and absence or presence of untoward events often associated with chronic use of hypnotics. RESULTS: A significant number of BD patients take NBZHs as needed or on a daily basis. Four NBZHs had adequate success rates; ramelteon was limited in efficacy. Some patients experienced satisfactory results from a NBZH after unsuccessful trials with one or more other NBZHs. About half of the current NBZH users are taking them on a daily long-term basis, and none of these patients have experienced unacceptable untoward events. About three quarters of the chronic NBZH users are taking antimanic medications concurrently, and less than half of the chronic users are taking antidepressants. LIMITATIONS: The results may not be generalizable to other BD populations. A control group was not included in the design. Chronic users of NBZHs were not asked to discontinue their NBZH in order to confirm indication for long-term use. CONCLUSIONS: Most NBZHs can be effective and safe agents for selected BD outpatients with episodic or chronic insomnia. Failure to respond to one or more NBZH does not preclude a satisfactory response to a different NBZH. Some BD patients who take maintenance antimanic agents also require NBZH treatment. Overactivation from antidepressant treatment does not contribute to chronic NBZH use in most BD patients.

9 Article A transactional model of sleep-wake regulation in infants born preterm or low birthweight. 2009

Schwichtenberg, A J M / Poehlmann, Julie. ·MIND Institute, University of California Davis, Sacramento, CA 95817, USA. ajschwichtenberg@ucdavis.edu ·J Pediatr Psychol · Pubmed #19098064.

ABSTRACT: OBJECTIVE: To test a transactional model of sleep-wake development in infants born preterm or low birthweight (PT LBW), which may inform clinical practice, interventions, and future research in this at risk population. METHODS: One hundred and twenty-eight mother-infant dyads participated from hospital discharge to 4 months postterm. Assessments of prematurity, infant sleep-wake patterns, maternal interaction quality, depression, feeding route, and sociodemographic factors were conducted. RESULTS: Path analyses revealed that maternal interactions directly related to infant sleep patterns and family sociodemographic risks related to less optimal parenting. In addition, bottle fed infants experienced fewer night wakings and more nighttime sleep. CONCLUSIONS: Two potential pathways to sleep patterns in PT LBW infants were identified. The findings suggest directions for clinical work, such as supporting healthy infant sleep through parenting interventions or supporting interpersonal relations between parents and their PT LBW infants by encouraging more daytime naps. Additionally, clinicians should assess parents' nighttime sleep concerns within the larger sociodemographic and feeding context.

10 Article Sleep patterns in preschool-age children with autism, developmental delay, and typical development. 2008

Goodlin-Jones, Beth L / Tang, Karen / Liu, Jingyi / Anders, Thomas F. ·Department of Psychiatry and Behavioral Sciences, University of California, Davis MIND Institute, USA. ·J Am Acad Child Adolesc Psychiatry · Pubmed #18596550.

ABSTRACT: OBJECTIVE: A prominent noncore symptom of autistic disorder is disturbed sleep, but relatively few studies have investigated this symptom. METHOD: A multimethod approach assessed the quantity and quality of sleep in 194 children (68 with autism [AUT], 57 with developmental delay without autism [DD], 69 with typical development) recorded over 1 week. Parent perceptions, structured questionnaires, and actigraphy were compared. In addition, problem sleep as defined by parents was compared with research diagnostic criteria for behavioral insomnia obtained from actigraph recordings. RESULTS: On actigraphy, children in the DD group, after sleep onset, exhibited more and longer awakenings than the other two groups. In contrast, children in the AUT group exhibited less total sleep time in 24 hours than the other two groups. Parent reports of sleep problems were higher in the AUT and DD groups than the typical development group, but parent reports did not concur with more objective RDC for behavioral insomnia. Parent reports of sleep problems in all of the groups were significantly associated with increased self-reports of stress. Total 24-hour sleep durations for all of the groups were shorter than recommended for preschool-age children. CONCLUSIONS: Our study provides objective evidence that sleep patterns are different in preschool children across the categories of AUT, DD, or typical development.

11 Article The use of actigraphy to study sleep disorders in preschoolers: some concerns about detection of nighttime awakenings. 2008

Sitnick, Stephanie L / Goodlin-Jones, Beth L / Anders, Thomas F. ·Department of Human and Community Development, UC Davis School of Medicine, University of California, Davis, Sacramento, USA. ·Sleep · Pubmed #18363316.

ABSTRACT: STUDY OBJECTIVES: This study compared actigraphy with videosomnography in preschool-aged children, with special emphasis on the accuracy of detection of nighttime awakenings. DESIGN: Fifty-eight participants wore an actigraph for 1 week and were videotaped for 2 nights while wearing the actigraph. SETTING: Participants were solitary sleepers, studied in their homes. PARTICIPANTS: One group (n = 22) was diagnosed with autism, another group (n = 11) had developmental delays without autism, and a third group (n = 25) were typically developing children; age ranged from 28 to 73 months (mean age 47 months); 29 boys and 29 girls. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Nocturnal sleep and wakefulness were scored from simultaneously recorded videosomnography and actigraphy. The accuracy of actigraphy was examined in an epoch-by-epoch comparison with videosomnography. Findings were 94% overall agreement, 97% sensitivity, and 24% specificity. Statistical corrections for overall agreement and specificity resulted in an 89% weighted-agreement and 27% adjusted specificity. CONCLUSIONS: Actigraphy has poor agreement for detecting nocturnal awakenings, compared with video observations, in preschool-aged children.