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Sleep Initiation and Maintenance Disorders: HELP
Articles from Miscellaneous institutions in Los Angeles
Based on 3 articles published since 2008

These are the 3 published articles about Sleep Initiation and Maintenance Disorders that originated from Miscellaneous institutions in Los Angeles during 2008-2019.
+ Citations + Abstracts
1 Article Prospective Longitudinal Study of Predictors of Postpartum-Onset Depression in Women With a History of Major Depressive Disorder. 2017

Suri, Rita / Stowe, Zachary N / Cohen, Lee S / Newport, D Jeffrey / Burt, Vivien K / Aquino-Elias, Ana R / Knight, Bettina T / Mintz, Jim / Altshuler, Lori L. ·760 Westwood Plaza, Ste 28-251, Los Angeles, CA 90095-7057. rsuri03@gmail.com. · Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, California, USA. · Jane and Terry Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, California, USA. · Departments of Psychiatry, Pediatrics, and Obstetrics & Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. · Perinatal and Reproductive Psychiatry Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. · Departments of Psychiatry & Behavioral Sciences and Obstetrics & Gynecology, University of Miami Miller School of Medicine, Florida, USA. · Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas, USA. ·J Clin Psychiatry · Pubmed #28297589.

ABSTRACT: OBJECTIVE: Risk factors for postpartum depression in euthymic pregnant women with histories of major depressive disorder (MDD) were evaluated. METHODS: From April 2003 to March 2009, 343 pregnant women with a history of Structured Clinical Interview for DSM-IV (SCID)-diagnosed major depressive disorder were prospectively assessed from the third trimester into the postpartum period using the SCID mood module and 17-item Hamilton Depression Rating Scale (HDRS). Data from 300 subjects who completed at least 2 mood module assessments (1 within 60 days before and the other within 60 days after delivery) were analyzed for predictive associations between variables assessed in the third trimester and the development of a postpartum depression. RESULTS: The majority of women were euthymic in pregnancy by SCID criteria. Women with third trimester SCID-diagnosed depression (n = 45) versus euthymia (n = 255) had a significantly higher risk for having depression after delivery (24% vs 11%, P = .013). For pregnant euthymic women, third trimester total HDRS scores significantly predicted postpartum depression (P < .0001); specifically, scores on 3 HDRS items alone-work activities, early insomnia, and suicidality-significantly predicted postpartum depression. Antidepressant use in the third trimester in euthymic women did not confer protection against the onset of postpartum depression. CONCLUSIONS: Among women with a history of MDD who are euthymic in the third trimester, 3 HDRS items-work activities, early insomnia, and suicidality-may be useful as screening items for clinicians working with pregnant women with histories of MDD to identify a group at risk for developing postpartum depression. Additionally, in euthymic women with a history of MDD, antidepressant use in the third trimester may not reduce the risk of developing postpartum depression.

2 Article Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study. 2017

Carroll, Judith E / Irwin, Michael R / Levine, Morgan / Seeman, Teresa E / Absher, Devin / Assimes, Themistocles / Horvath, Steve. ·Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles. Electronic address: jcarroll@mednet.ucla.edu. · Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles. · Department of Human Genetics, Los Angeles. · Department of Geriatrics, David Geffen School of Medicine, Los Angeles. · HudsonAlpha Institute for Biotechnology, Huntsville, Alabama. · Department of Medicine, Stanford University, Palo Alto, California. · Department of Human Genetics, Los Angeles; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles. ·Biol Psychiatry · Pubmed #27702440.

ABSTRACT: BACKGROUND: Insomnia symptoms are associated with vulnerability to age-related morbidity and mortality. Cross-sectional data suggest that accelerated biological aging may be a mechanism through which sleep influences risk. A novel method for determining age acceleration using epigenetic methylation to DNA has demonstrated predictive utility as an epigenetic clock and prognostic of age-related morbidity and mortality. METHODS: We examined the association of epigenetic age and immune cell aging with sleep in the Women's Health Initiative study (N = 2078; mean 64.5 ± 7.1 years of age) with assessment of insomnia symptoms (restlessness, difficulty falling asleep, waking at night, trouble getting back to sleep, and early awakenings), sleep duration (short sleep 5 hours or less; long sleep greater than 8 hours), epigenetic age, naive T cell (CD8+CD45RA+CCR7+), and late differentiated T cells (CD8+CD28-CD45RA-). RESULTS: Insomnia symptoms were related to advanced epigenetic age (β ± SE = 1.02 ± 0.37, p = .005) after adjustments for covariates. Insomnia symptoms were also associated with more late differentiated T cells (β ± SE = 0.59 ± 0.21, p = .006), but not with naive T cells. Self-reported short and long sleep duration were unrelated to epigenetic age. Short sleep, but not long sleep, was associated with fewer naive T cells (p < .005) and neither was related to late differentiated T cells. CONCLUSIONS: Symptoms of insomnia were associated with increased epigenetic age of blood tissue and were associated with higher counts of late differentiated CD8+ T cells. Short sleep was unrelated to epigenetic age and late differentiated cell counts, but was related to a decline in naive T cells. In this large population-based study of women in the United States, insomnia symptoms are implicated in accelerated aging.

3 Article Evaluating and managing insomnia. 2009

Fisher, Diane / Valente, Sharon. ·Department of Veteran Affairs, Los Angeles, California, USA. ·Nurse Pract · Pubmed #19638890.

ABSTRACT: -- No abstract --