Pick Topic
Review Topic
List Experts
Examine Expert
Save Expert
  Site Guide ··   
Sleep Initiation and Maintenance Disorders: HELP
Articles by Chen Zhao
Based on 1 article published since 2009
(Why 1 article?)
||||

Between 2009 and 2019, Chen Zhao wrote the following article about Sleep Initiation and Maintenance Disorders.
 
+ Citations + Abstracts
1 Article Biological and clinical insights from genetics of insomnia symptoms. 2019

Lane, Jacqueline M / Jones, Samuel E / Dashti, Hassan S / Wood, Andrew R / Aragam, Krishna G / van Hees, Vincent T / Strand, Linn B / Winsvold, Bendik S / Wang, Heming / Bowden, Jack / Song, Yanwei / Patel, Krunal / Anderson, Simon G / Beaumont, Robin N / Bechtold, David A / Cade, Brian E / Haas, Mary / Kathiresan, Sekar / Little, Max A / Luik, Annemarie I / Loudon, Andrew S / Purcell, Shaun / Richmond, Rebecca C / Scheer, Frank A J L / Schormair, Barbara / Tyrrell, Jessica / Winkelman, John W / Winkelmann, Juliane / Anonymous5371464 / Hveem, Kristian / Zhao, Chen / Nielsen, Jonas B / Willer, Cristen J / Redline, Susan / Spiegelhalder, Kai / Kyle, Simon D / Ray, David W / Zwart, John-Anker / Brumpton, Ben / Frayling, Timothy M / Lawlor, Deborah A / Rutter, Martin K / Weedon, Michael N / Saxena, Richa. ·Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. · Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. · Broad Institute, Cambridge, MA, USA. · Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK. · Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. · Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. · Netherlands eScience Center, Amsterdam, the Netherlands. · K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. · FORMI and Department of Neurology, Oslo University Hospital, Oslo, Norway. · Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway. · Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA. · Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA. · MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. · Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. · College of Science, Northeastern University, Boston, MA, USA. · Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. · Farr Institute of Health Informatics Research, University College London, London, UK. · Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. · Department of Mathematics, Aston University, Birmingham, UK. · Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA. · Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. · Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. · Department of Psychiatry, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA. · School of Social and Community Medicine, University of Bristol, Bristol, UK. · Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK. · Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. · Departments of Psychiatry and Neurology, Massachusetts General Hospital, Boston, MA, USA. · Cluster for Systems Neurology (SyNergy), Munich, Germany. · Institute of Human Genetics, Technische Universität München, Munich, Germany. · Neurogenetics, Technische Universität München, Munich, Germany. · Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. · Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA. · Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. · Departments of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. · Clinic for Psychiatry and Psychotherapy, Medical Centre-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. · Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE/NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK. · Department of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. · Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. · Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. rsaxena@partners.org. · Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. rsaxena@partners.org. · Broad Institute, Cambridge, MA, USA. rsaxena@partners.org. ·Nat Genet · Pubmed #30804566.

ABSTRACT: Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal glands. Evidence of shared genetic factors was found between frequent insomnia symptoms and restless legs syndrome, aging, and cardiometabolic, behavioral, psychiatric, and reproductive traits. Evidence was found for a possible causal link between insomnia symptoms and coronary artery disease, depressive symptoms, and subjective well-being.