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Sleep Initiation and Maintenance Disorders: HELP
Articles by Matthew P. Walker
Based on 7 articles published since 2008
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Between 2008 and 2019, Matthew Walker wrote the following 7 articles about Sleep Initiation and Maintenance Disorders.
 
+ Citations + Abstracts
1 Editorial Obligate symbiosis: sleep and affect. 2010

Walker, Matthew P / Harvey, Allison G. · ·Sleep Med Rev · Pubmed #20427211.

ABSTRACT: -- No abstract --

2 Review Cognitive consequences of sleep and sleep loss. 2008

Walker, Matthew P. ·Sleep and Neuroimaging Laboratory, Department of Psychology, University of California, Berkeley, CA 94720-1650, USA. mpwalker@berkeley.edu ·Sleep Med · Pubmed #18929316.

ABSTRACT: Although we still lack any consensus function(s) for sleep, accumulating evidence suggests it plays an important role in homeostatic restoration, thermoregulation, tissue repair, immune control and memory processing. In the last decade an increasing number of reports continue to support a bidirectional and symbiotic relationship between sleep and memory. Studies using procedural and declarative learning tasks have demonstrated the need for sleep after learning in the offline consolidation of new memories. Furthermore, these consolidation benefits appear to be mediated by an overnight neural reorganization of memory that may result in a more efficient storage of information, affording improved next-day recall. Sleep before learning also appears to be critical for brain functioning. Specifically, one night of sleep deprivation markedly impairs hippocampal function, imposing a deficit in the ability to commit new experiences to memory. Taken together, these observations are of particular ecologic importance from a professional and education perspective when considering that sleep time continues to decrease across all age ranges throughout industrialized nations.

3 Article Sleep loss causes social withdrawal and loneliness. 2018

Ben Simon, Eti / Walker, Matthew P. ·Center for Human Sleep Science, Department of Psychology, University of California, Berkeley, CA, 94720-1650, USA. etibens@berkeley.edu. · Center for Human Sleep Science, Department of Psychology, University of California, Berkeley, CA, 94720-1650, USA. mpwalker@berkeley.edu. · Helen Wills Neuroscience Institute, University of California, Berkeley, CA, 94720-1650, USA. mpwalker@berkeley.edu. ·Nat Commun · Pubmed #30108218.

ABSTRACT: Loneliness and social isolation markedly increase mortality risk, and are linked to numerous mental and physical comorbidities, including sleep disruption. But does sleep loss causally trigger loneliness? Here, we demonstrate that a lack of sleep leads to a neural and behavioral phenotype of social withdrawal and loneliness; one that can be perceived by other members of society, and reciprocally, makes those societal members lonelier in return. We propose a model in which sleep loss instigates a propagating, self-reinforcing cycle of social separation and withdrawal.

4 Article Sleep the night before and after a treatment session: A critical ingredient for treatment adherence? 2017

Dolsen, Michael R / Soehner, Adriane M / Morin, Charles M / Bélanger, Lynda / Walker, Matthew / Harvey, Allison G. ·Department of Psychology, University of California, Berkeley. · Department of Psychiatry, University of Pittsburgh School of Medicine. · École de Psychologie, Université Laval. ·J Consult Clin Psychol · Pubmed #28394172.

ABSTRACT: OBJECTIVE: Sleep prepares key neural structures for next-day learning, and sleep obtained after learning promotes subsequent memory consolidation supporting long-term retention. This study examined whether sleep the night before and after a therapy session predicts aspects of treatment adherence. METHOD: As part of a randomized clinical trial, 188 adults (62.7% female, mean age = 47.5, 80.5% Caucasian) with persistent insomnia received cognitive-behavioral therapy for insomnia. Patients completed a sleep diary before and after treatment sessions. Minutes spent awake during the night (total wake time; TWT) and total sleep time (TST) were used as measures of sleep disturbance. At each treatment session, therapists rated participant understanding of the session and homework compliance from the previous session. RESULTS: Compared to longer TWT, before session shorter TWT was associated with increased treatment understanding the next day. After session shorter TWT was also associated with increased understanding, but not homework compliance the subsequent session compared to participants with longer TWT. Similar results were obtained for TST. CONCLUSIONS: Improving sleep may benefit patient adherence to treatment. Sleep may influence processes related to initial learning and subsequent consolidation of treatment information. Future studies should examine whether improved sleep within other psychiatric disorders is also an ingredient to the successful outcome of psychosocial interventions. (PsycINFO Database Record

5 Article Slow dissolving of emotional distress contributes to hyperarousal. 2016

Wassing, Rick / Benjamins, Jeroen S / Dekker, Kim / Moens, Sarah / Spiegelhalder, Kai / Feige, Bernd / Riemann, Dieter / van der Sluis, Sophie / Van Der Werf, Ysbrand D / Talamini, Lucia M / Walker, Matthew P / Schalkwijk, Frans / Van Someren, Eus J W. ·Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, 1105 BA, Amsterdam, The Netherlands; r.wassing@nin.knaw.nl. · Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, 1105 BA, Amsterdam, The Netherlands; Department of Social, Health and Organizational Psychology, Experimental Psychology Section, Utrecht University, 3584 CS, Utrecht, The Netherlands; · Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, 1105 BA, Amsterdam, The Netherlands; · Department of Clinical Psychology and Psychophysiology, University Medical Center Freiburg, 79104 Freiburg, Germany; · Department of Clinical Genetics, Complex Trait Genetics Section, Vrije Universiteit Medical Center, 1081 HV, Amsterdam, The Netherlands; · Department of Anatomy and Neurosciences, Vrije Universiteit Medical Center, 1007 MB, Amsterdam, The Netherlands; · Department of Psychology, University of Amsterdam, 1021 WX, Amsterdam, The Netherlands; · Department of Psychology, University of California, Berkeley, CA 94720-1650; · Institute for Psychotherapy, 1076 AP, Amsterdam, The Netherlands; · Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, 1105 BA, Amsterdam, The Netherlands; Department of Medical Psychology, Vrije Universiteit Medical Center, 1081 HZ, Amsterdam, The Netherlands; Department of Integrative Neurophysiology, Neuroscience Campus, Vrije Universiteit, 1081 HV, Amsterdam, The Netherlands. ·Proc Natl Acad Sci U S A · Pubmed #26858434.

ABSTRACT: The mechanisms underlying hyperarousal, the key symptom of insomnia, have remained elusive, hampering cause-targeted treatment. Recently, restless rapid-eye-movement (REM) sleep emerged as a robust signature of sleep in insomnia. Given the role of REM sleep in emotion regulation, we hypothesized that restless REM sleep could interfere with the overnight resolution of emotional distress, thus contributing to accumulation of arousal. Participants (n = 1,199) completed questionnaires on insomnia severity, hyperarousal, self-conscious emotional distress, and thought-like nocturnal mentation that was validated to be a specific proxy for restless REM sleep (selective fragmentation: R = 0.57, P < 0.001; eye movement density: R = 0.46, P < 0.01) in 32 polysomnographically assessed participants. The experience of distress lasting overnight increased with insomnia severity (β = 0.29, P < 10(-23)), whereas short-lasting distress did not (β = -0.02, P = 0.41). Insomnia severity was associated with hyperarousal (β = 0.47, P < 10(-63)) and with the thought-like nocturnal mentation that is specifically associated with restless REM sleep (β = 0.31, P < 10(-26)). Structural equation modeling showed that 62.4% of the association between these key characteristics of insomnia was mediated specifically by reduced overnight resolution of emotional distress. The model outperformed all alternative mediation pathways. The findings suggest that restless REM sleep reflects a process that interferes with the overnight resolution of distress. Its accumulation may promote the development of chronic hyperarousal, giving clinical relevance to the role of REM sleep in emotion regulation in insomnia, depression, and posttraumatic stress disorder.

6 Article Neural correlates of working memory performance in primary insomnia. 2013

Drummond, Sean P A / Walker, Matthew / Almklov, Erin / Campos, Manuel / Anderson, Dane E / Straus, Laura D. ·Psychology Service, VA San Diego Healthcare System, San Diego, CA 92161, USA. drummond@ucsd.edu ·Sleep · Pubmed #23997363.

ABSTRACT: STUDY OBJECTIVES: To examine neural correlates of working memory performance in patients with primary insomnia (PIs) compared with well-matched good sleepers (GSs). DESIGN: Twenty-five PIs and 25 GSs underwent functional MRI while performing an N-back working memory task. SETTING: VA hospital sleep laboratory and University-based functional imaging center. PATIENTS OR PARTICIPANTS: 25 PIs, 25 GSs. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Although PIs did not differ from GSs in cognitive performance, PIs showed the expected differences from GSs in both self-reported and objective sleep measures. PIs, relative to GSs, showed reduced activation of task-related working memory regions. This manifested both as an overall reduction in activation of task-related regions and specifically as reduced modulation of right dorsolateral prefrontal cortex with increasing task difficulty. Similarly, PIs showed reduced modulation (i.e., reduced deactivation) of default mode regions with increasing task difficulty, relative to GSs. However, PIs showed intact performance. CONCLUSIONS: These data establish a profile of abnormal neural function in primary insomnia, reflected both in reduced engagement of task-appropriate brain regions and an inability to modulate task-irrelevant (i.e., default mode) brain areas during working memory performance. These data have implications for better understanding the neuropathophysiology of the well established, yet little understood, discrepancy between ubiquitous subjective cognitive complaints in primary insomnia and the rarely found objective deficits during testing.

7 Article Rapid eye movement sleep disturbances in Huntington disease. 2008

Arnulf, Isabelle / Nielsen, Jørgen / Lohmann, Ebba / Schiefer, Johannes / Wild, Edward / Jennum, Poul / Konofal, Eric / Walker, Matthew / Oudiette, Delphine / Tabrizi, Sarah / Durr, Alexandra. ·Pathologies du Sommeil, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (AP-HP), and U106, University Pierre and Marie Curie, Paris CEDEX 13, France. isabelle.arnulf@psl.aphp.fr ·Arch Neurol · Pubmed #18413470.

ABSTRACT: BACKGROUND: Sleep disorders including insomnia, movements during sleep, and daytime sleepiness are common but poorly studied in Huntington disease (HD). OBJECTIVE: To evaluate the HD sleep-wake phenotype (including abnormal motor activity during sleep) in patients with various HD stages and the length of CAG repeats. Because a mild hypocretin deficiency has been found in the brains of some patients with HD (hereinafter referred to as HD patients), we also tested the HD patients for narcolepsy. DESIGN AND PATIENTS: Twenty-five HD patients (including 2 premanifest carriers) underwent clinical interview, nighttime video and sleep monitoring, and daytime multiple sleep latency tests. Their results were compared with those of patients with narcolepsy and control patients. RESULTS: The HD patients had frequent insomnia, earlier sleep onset, lower sleep efficiency, increased stage 1 sleep, delayed and shortened rapid eye movement (REM) sleep, and increased periodic leg movements. Three HD patients (12%) had REM sleep behavior disorders. No sleep abnormality correlated with CAG repeat length. Reduced REM sleep duration (but not REM sleep behavior disorders) was present in premanifest carriers and patients with very mild HD and worsened with disease severity. In contrast to narcoleptic patients, HD patients had no cataplexy, hypnagogic hallucinations, or sleep paralysis. Four HD patients had abnormally low (< 8 minutes) daytime sleep latencies, but none had multiple sleep-onset REM periods. CONCLUSIONS: The sleep phenotype of HD includes insomnia, advanced sleep phase, periodic leg movements, REM sleep behavior disorders, and reduced REM sleep but not narcolepsy. Reduced REM sleep may precede chorea. Mutant huntingtin may exert an effect on REM sleep and motor control during sleep.