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Sleep Initiation and Maintenance Disorders: HELP
Articles by Daniel F. Kripke
Based on 7 articles published since 2008
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Between 2008 and 2019, Daniel F. Kripke wrote the following 7 articles about Sleep Initiation and Maintenance Disorders.
 
+ Citations + Abstracts
1 Editorial Surprising view of insomnia and sleeping pills. 2013

Kripke, Daniel F. · ·Sleep · Pubmed #23904671.

ABSTRACT: -- No abstract --

2 Editorial Do hypnotics cause death and cancer? The burden of proof. 2009

Kripke, Daniel F. · ·Sleep Med · Pubmed #19269891.

ABSTRACT: -- No abstract --

3 Article Possibility that certain hypnotics might cause cancer in skin. 2008

Kripke, Daniel F. ·Department of Psychiatry, University of California, San Diego and The Scripps Clinic Sleep Center, La Jolla, California 92093-0667, USA. dkripke@ucsd.edu ·J Sleep Res · Pubmed #18844818.

ABSTRACT: Fifteen epidemiologic studies have associated hypnotic drugs with excess mortality, especially excess cancer deaths. Until recently, insufficient controlled trials were available to demonstrate whether hypnotics actually cause any cancers. The US Food and Drug Administration (FDA) Approval History and Documents were accessed for zaleplon, eszopiclone and ramelteon. Since zolpidem was used as a comparison drug in zaleplon trials, some zolpidem data were also available. Incident cancers occurring during randomized hypnotics administration or placebo administration were tabulated. Combining controlled trials for the four drugs, there were 6190 participants given hypnotics and 2535 given placebo in parallel. There were eight mentions of incident non-melanoma skin cancers among participants receiving hypnotics but no comparable mentions of cancers among those receiving placebo (P = 0.064, one-tailed). There were also four mentions of incident tumors of uncertain malignancy among those receiving hypnotics but none among those receiving placebo, so combining uncertain and definite malignancies yielded a more significant contrast (P = 0.016). FDA files revealed that all four of the new hypnotics were associated with cancers in rodents. Three had been shown to be clastogenic. Together with the epidemiologic data and laboratory studies, the available evidence signals that new hypnotics may increase cancer risk. Due to limitations in available data, confirmatory research is needed.

4 Minor "Rebound" is not an appropriate criterion for withdrawal insomnia. 2014

Kripke, Daniel F. ·Viterbi Family Sleep Center, Scripps Clinic W-207, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: dkripke1@san.rr.com. ·Sleep Med · Pubmed #25441753.

ABSTRACT: -- No abstract --

5 Minor Hypnotics cause insomnia: evidence from clinical trials. 2014

Kripke, Daniel F. ·Viterbi Family Sleep Center, Scripps Clinic W-207, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: dkripke1@san.rr.com. ·Sleep Med · Pubmed #25152199.

ABSTRACT: -- No abstract --

6 Minor Insomnia: More trials needed to assess sleeping pills. 2013

Moser, Maximilian / Kripke, Daniel F. · ·Nature · Pubmed #23325202.

ABSTRACT: -- No abstract --

7 Minor Is insomnia associated with mortality? 2011

Kripke, Daniel F. · ·Sleep · Pubmed #21532944.

ABSTRACT: -- No abstract --