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Sleep Initiation and Maintenance Disorders: HELP
Articles by Mary L. Francois
Based on 1 article published since 2008

Between 2008 and 2019, Mary L. Francois wrote the following article about Sleep Initiation and Maintenance Disorders.
+ Citations + Abstracts
1 Article Restless Legs Syndrome Following Lung Transplantation: Prevalence and Relationship With Tacrolimus Exposure. 2016

Menninga, Nathan J / Rohde, Kalynn A / Schlei, Zachary W / Katers, Krista M / Weber, Ashley K / Brokhof, Marissa M / Hawes, Donald S / Radford, Kelly L / Francois, Mary L / Cornwell, Richard D / Benca, Ruth / Hayney, Mary S / Dopp, John M. ·Pharmacy Practice Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA. · University of Wisconsin Hospitals and Clinics, University of Wisconsin-Madison, Madison, WI, USA. · Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA. · Wisconsin Sleep Center and Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. · Pharmacy Practice Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA john.dopp@wisc.edu. ·Prog Transplant · Pubmed #27207403.

ABSTRACT: CONTEXT: Complications following lung transplantation are common and significantly reduce quality of life, and increase morbidity and mortality. Increasing evidence suggests sleep disorders are prevalent following lung transplantation, but factors associated with their development are not known. OBJECTIVES: We sought to evaluate the prevalence of restless legs syndrome (RLS) in a lung transplant population and determine if a relationship exists between RLS and exposure to immunosuppressant medications. DESIGN, SETTING, AND PARTICIPANTS: Subjects were recruited through the University of Wisconsin Hospital and Clinics Lung Transplant Clinic (N = 125). Participants (N = 81) completed sleep questionnaires, including the four RLS diagnostic criteria, insomnia severity index, and Sheehan disability scale. Cumulative tacrolimus exposure was determined in 62 subjects by calculating an area under the curve (AUC) to assess for a relationship with restless legs syndrome. RESULTS: Prevalence of RLS was 35 percent. Cumulative mean ± SEM tacrolimus exposure was similar in patients with RLS versus those without RLS (17446 ± 1855 ng days/mL vs. 15303 ± 1643 ng days/mL, respectively; p = 0.42). Insomnia severity index scores (12.5 ± 1.0 vs 6.8 ± 0.7, p < 0.0001) and Sheehan disability scores (7.8 ± 1.3 vs 3.6 ± 0.6, p = 0.003) were significantly higher in those with vs those without RLS symptoms, respectively. CONCLUSIONS: Our data confirms increased prevalence of RLS following lung transplantation reported by previous studies. RLS symptoms were not related to estimated tacrolimus exposure. Predictors of RLS following lung transplantation need to be further investigated to better identify and control RLS symptoms and reduce associated insomnia and disability.