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Sleep Initiation and Maintenance Disorders: HELP
Articles by Devin Absher
Based on 1 article published since 2009
(Why 1 article?)

Between 2009 and 2019, Devin Absher wrote the following article about Sleep Initiation and Maintenance Disorders.
+ Citations + Abstracts
1 Article Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study. 2017

Carroll, Judith E / Irwin, Michael R / Levine, Morgan / Seeman, Teresa E / Absher, Devin / Assimes, Themistocles / Horvath, Steve. ·Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles. Electronic address: jcarroll@mednet.ucla.edu. · Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles. · Department of Human Genetics, Los Angeles. · Department of Geriatrics, David Geffen School of Medicine, Los Angeles. · HudsonAlpha Institute for Biotechnology, Huntsville, Alabama. · Department of Medicine, Stanford University, Palo Alto, California. · Department of Human Genetics, Los Angeles; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles. ·Biol Psychiatry · Pubmed #27702440.

ABSTRACT: BACKGROUND: Insomnia symptoms are associated with vulnerability to age-related morbidity and mortality. Cross-sectional data suggest that accelerated biological aging may be a mechanism through which sleep influences risk. A novel method for determining age acceleration using epigenetic methylation to DNA has demonstrated predictive utility as an epigenetic clock and prognostic of age-related morbidity and mortality. METHODS: We examined the association of epigenetic age and immune cell aging with sleep in the Women's Health Initiative study (N = 2078; mean 64.5 ± 7.1 years of age) with assessment of insomnia symptoms (restlessness, difficulty falling asleep, waking at night, trouble getting back to sleep, and early awakenings), sleep duration (short sleep 5 hours or less; long sleep greater than 8 hours), epigenetic age, naive T cell (CD8+CD45RA+CCR7+), and late differentiated T cells (CD8+CD28-CD45RA-). RESULTS: Insomnia symptoms were related to advanced epigenetic age (β ± SE = 1.02 ± 0.37, p = .005) after adjustments for covariates. Insomnia symptoms were also associated with more late differentiated T cells (β ± SE = 0.59 ± 0.21, p = .006), but not with naive T cells. Self-reported short and long sleep duration were unrelated to epigenetic age. Short sleep, but not long sleep, was associated with fewer naive T cells (p < .005) and neither was related to late differentiated T cells. CONCLUSIONS: Symptoms of insomnia were associated with increased epigenetic age of blood tissue and were associated with higher counts of late differentiated CD8+ T cells. Short sleep was unrelated to epigenetic age and late differentiated cell counts, but was related to a decline in naive T cells. In this large population-based study of women in the United States, insomnia symptoms are implicated in accelerated aging.