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Pancreatic Neoplasms: HELP
Articles by Zhen Zhao
Based on 3 articles published since 2010
(Why 3 articles?)
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Between 2010 and 2020, Zhen Zhao wrote the following 3 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Development of a Tumor-Responsive Nanopolyplex Targeting Pancreatic Cancer Cells and Stroma. 2019

Li, Yuanke / Zhao, Zhen / Liu, Hao / Fetse, John Peter / Jain, Akshay / Lin, Chien-Yu / Cheng, Kun. ·Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy , University of Missouri-Kansas City , 2464 Charlotte Street , Kansas City , Missouri 64108 , United States. ·ACS Appl Mater Interfaces · Pubmed #31769963.

ABSTRACT: Desmoplasia plays a pivotal role in promoting pancreatic cancer progression and is associated with poor clinical outcome. Targeting the desmoplastic tumor microenvironment in combination with chemotherapy is therefore a promising strategy for pancreatic cancer therapy. Here, we report a novel biodegradable copolymer to codeliver LY2109761 (a TGF-╬▓ receptor I/II inhibitor) and CPI-613 (a novel chemotherapy agent) to desmoplastic stroma and tumor cells, respectively, in the tumor microenvironment. Hydrophobic CPI-613 is conjugated to the hydrophilic copolymer via a newly designed MMP-2-responsive linker to form a trigger-responsive nanopolyplex. LY2109761 is hydrophobic and encapsulated into the hydrophobic core of the nanopolyplex. The resulting nanopolyplex is modified with a plectin-1-targeting peptide to enhance the accumulation of the nanopolyplex in pancreatic tumors. The nanopolyplex aims to normalize the stroma by blocking the interaction between tumor cells and pancreatic stellate cells to inhibit the activation of pancreatic stellate cells and subsequently reduce the dense extracellular matrix. Normalized stroma increases the penetration of the nanopolyplex into the tumor. The nanopolyplex shows enhanced accumulation in xenograft pancreatic tumors in a biodistribution study. Moreover, the targeted nanopolyplex markedly inhibits tumor growth in an orthotopic pancreatic cancer mouse model by dual-targeting tumor cells and stroma. Overall, the multifunctional nanopolyplex is a promising platform for pancreatic cancer therapy.

2 Article Chemoresistance Transmission via Exosome-Mediated EphA2 Transfer in Pancreatic Cancer. 2018

Fan, Jia / Wei, Qian / Koay, Eugene J / Liu, Yang / Ning, Bo / Bernard, Paul W / Zhang, Ning / Han, Haiyong / Katz, Matthew H / Zhao, Zhen / Hu, Ye. ·School of Biological and Health Systems Engineering, Virginia G. Piper Biodesign Center for Personalized Diagnostics, The Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA. · Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, PR China. · Division of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. · Research Center of Basic Medical Sciences & Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin 300070, PR China. · Center for Molecular Design and Biomimetics, The Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA. · Department of Nanomedicine, Houston Methodist Research Institute, Houston, Texas 77030, USA. · Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA. · Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. · Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. · Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA. ·Theranostics · Pubmed #30613276.

ABSTRACT:

3 Article Sensitive tumour detection and classification using plasma cell-free DNA methylomes. 2018

Shen, Shu Yi / Singhania, Rajat / Fehringer, Gordon / Chakravarthy, Ankur / Roehrl, Michael H A / Chadwick, Dianne / Zuzarte, Philip C / Borgida, Ayelet / Wang, Ting Ting / Li, Tiantian / Kis, Olena / Zhao, Zhen / Spreafico, Anna / Medina, Tiago da Silva / Wang, Yadon / Roulois, David / Ettayebi, Ilias / Chen, Zhuo / Chow, Signy / Murphy, Tracy / Arruda, Andrea / O'Kane, Grainne M / Liu, Jessica / Mansour, Mark / McPherson, John D / O'Brien, Catherine / Leighl, Natasha / Bedard, Philippe L / Fleshner, Neil / Liu, Geoffrey / Minden, Mark D / Gallinger, Steven / Goldenberg, Anna / Pugh, Trevor J / Hoffman, Michael M / Bratman, Scott V / Hung, Rayjean J / De Carvalho, Daniel D. ·Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. · Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada. · Memorial Sloan Kettering Cancer Center, New York, NY, USA. · Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. · Genome Technologies, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. · UMR_S 1236, Univ Rennes 1, Inserm, Etablissement Fran├žais du sang Bretagne, Rennes, France. · Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, Sacramento, CA, USA. · Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. · Fred Litwin Centre for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. · Department of Surgery, Toronto General Hospital, Toronto, Ontario, Canada. · Department of Computer Science, University of Toronto, Toronto, Ontario, Canada. · Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada. rayjean.hung@lunenfeld.ca. · Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. rayjean.hung@lunenfeld.ca. · Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. ddecarv@uhnresearch.ca. · Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. ddecarv@uhnresearch.ca. ·Nature · Pubmed #30429608.

ABSTRACT: The use of liquid biopsies for cancer detection and management is rapidly gaining prominence