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Pancreatic Neoplasms: HELP
Articles by Akihiko Yoshizawa
Based on 7 articles published since 2010
(Why 7 articles?)
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Between 2010 and 2020, Akihiko Yoshizawa wrote the following 7 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4. 2017

Hosoda, Waki / Chianchiano, Peter / Griffin, James F / Pittman, Meredith E / Brosens, Lodewijk Aa / Noë, Michaël / Yu, Jun / Shindo, Koji / Suenaga, Masaya / Rezaee, Neda / Yonescu, Raluca / Ning, Yi / Albores-Saavedra, Jorge / Yoshizawa, Naohiko / Harada, Kenichi / Yoshizawa, Akihiko / Hanada, Keiji / Yonehara, Shuji / Shimizu, Michio / Uehara, Takeshi / Samra, Jaswinder S / Gill, Anthony J / Wolfgang, Christopher L / Goggins, Michael G / Hruban, Ralph H / Wood, Laura D. ·Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. · Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. · Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA. · Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands. · Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. · Department of Pathology, Medica Sur Clinic and Foundation, Mexico City, Mexico. · The First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan. · Department of Human Pathology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan. · Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan. · Center for Gastroendoscopy, Onomichi General Hospital, Onomichi, Japan. · Department of Pathology, Onomichi General Hospital, Onomich, Japan. · Diagnostic Pathology Center, Hakujikai Memorial Hospital, Tokyo, Japan. · Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan. · Department of Gastrointestinal Surgery, Royal North Shore Hospital and Discipline of Surgery, University of Sydney, Sydney, Australia. · Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research Royal North Shore Hospital and University of Sydney, Sydney, Australia. · Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. · Department of Medicine, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. ·J Pathol · Pubmed #28188630.

ABSTRACT: High-grade pancreatic intraepithelial neoplasia (HG-PanIN) is the major precursor of pancreatic ductal adenocarcinoma (PDAC) and is an ideal target for early detection. To characterize pure HG-PanIN, we analysed 23 isolated HG-PanIN lesions occurring in the absence of PDAC. Whole-exome sequencing of five of these HG-PanIN lesions revealed a median of 33 somatic mutations per lesion, with a total of 318 mutated genes. Targeted next-generation sequencing of 17 HG-PanIN lesions identified KRAS mutations in 94% of the lesions. CDKN2A alterations occurred in six HG-PanIN lesions, and RNF43 alterations in five. Mutations in TP53, GNAS, ARID1A, PIK3CA, and TGFBR2 were limited to one or two HG-PanINs. No non-synonymous mutations in SMAD4 were detected. Immunohistochemistry for p53 and SMAD4 proteins in 18 HG-PanINs confirmed the paucity of alterations in these genes, with aberrant p53 labelling noted only in three lesions, two of which were found to be wild type in sequencing analyses. Sixteen adjacent LG-PanIN lesions from ten patients were also sequenced using targeted sequencing. LG-PanIN harboured KRAS mutations in 94% of the lesions; mutations in CDKN2A, TP53, and SMAD4 were not identified. These results suggest that inactivation of TP53 and SMAD4 are late genetic alterations, predominantly occurring in invasive PDAC. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

2 Article A case of MUC5AC-positive intraductal neoplasm of the pancreas classified as an intraductal tubulopapillary neoplasm? 2015

Muraki, Takashi / Uehara, Takeshi / Sano, Kenji / Oota, Hiroyoshi / Yoshizawa, Akihiko / Asaka, Shiho / Tateishi, Ayako / Otsuki, Toshiaki / Shingu, Kunihiko / Matoba, Hisanori / Kobayashi, Shota / Ichimata, Shojiro / Watanabe, Takayuki / Itou, Tetsuya / Tanaka, Eiji. ·Department of Medicine, Gastroenterology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. · Department of Laboratory Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. Electronic address: tuehara@shinshu-u.ac.jp. · Department of Laboratory Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. · Department of Biomedical Laboratory Sciences, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. ·Pathol Res Pract · Pubmed #26586167.

ABSTRACT: This report describes a unique case of intraductal tubulopapillary neoplasm (ITPN) of the pancreas in order to clarify its oncogenesis and more precisely classify pancreatic intraductal neoplasms. A 74-year-old man visited our institution for follow-up of acute pancreatitis. Imaging examinations revealed a hypovascular intraductal mass in the head of the pancreas with progressive dilation of the pancreatic duct, atrophy of the pancreatic parenchyma, and a non-mucinous appearance. A pancreatoduodenectomy was performed to identify this pancreatic intraductal neoplasm. Macroscopically, the tumor was a solid nodular mass with no visibly secreted mucin obstructing the dilated ducts. Histologically, it had a homogeneous appearance with nodules of back-to-back tubular glands and occasional papillary elements, and there were no apparent transitions to areas with less marked cytoarchitectural atypia. Although the intraductal neoplastic growth corresponded to an ITPN, immunohistochemical staining revealed partial positivity for MUC5AC, for which ITPNs are characteristically negative. Somatic mutations in KRAS, GNAS, BRAF, and PIK3CA were not detected. A loss of MUC5AC expression and mutations in KRAS and GNAS are key elements in the diagnosis of ITPN. Thus, it was difficult to distinguish the present case as a pancreatobiliary-type (PB-type) intraductal papillary mucinous neoplasm (IPMN) or a phenotypic variant of ITPN. As it is possible that some cases of PB-type IPMN and ITPN overlap, the precise classification of these rare lesions may require re-evaluation.

3 Article Comparison of histopathological features of pancreatic carcinoma and type 1 autoimmune pancreatitis. 2014

Uehara, Takeshi / Hamano, Hideaki / Kawa, Shigeyuki / Kobayashi, Yukihiro / Yoshizawa, Akihiko / Oki, Keiko / Nakata, Rie / Kobayashi, Akira / Sano, Kenji / Ota, Hiroyoshi. ·Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan. ·Pathol Int · Pubmed #24629172.

ABSTRACT: Type 1 autoimmune pancreatitis (AIP-1) is an immunoglobulin G (IgG)-4-related disease (IgG4-RD), characterized by elevated serum immunoglobulin G4 (IgG4) and infiltration by IgG4(+) plasma cells. Pancreatic carcinoma (PC) sometimes shows infiltration by IgG4(+) plasma cells, but details have been unclear. We compared pathological findings and expression of IgG4 and IgG in fibroses in 18 PC patients to those from 9 AIP-1 patients. Fibroses were divided into areas of ductal adenocarcinoma (DA) and obstructive pancreatitis (OP). Serum IgG4 levels were lower than the cut-off value in all PC patients with no IgG4-RD. Diffuse lymphoplasmacytic infiltration and eosinophil infiltration were characteristic of fibroses in PC. Though AIP-1 samples often had storiform fibrosis even in biopsies, PC did not show storiform fibrosis. Ratios of IgG4(+) plasma cells/IgG(+) plasma cells (IgG4/IgG ratios) in DA and OP were significantly lower than in AIP-1. However, high-density IgG4(+) plasma cell foci were detected in PC fibroses, particularly around peripheral nerves, vessels, and lymphoid follicles; between lobules and invasion fronts; and within neutrophilic abscesses. In conclusion, the IgG4/IgG ratio is useful in distinguishing PC from AIP-1, and should be evaluated in three or more areas, as PC can show localized high-density IgG4(+) plasma cell areas.

4 Article [Utility of rapid on-site cytology in endoscopic ultrasonography-guided fine needle aspiration of pancreatic masses]. 2012

Furuhata, Ayako / Shirahase, Hiroyuki / Shirai, Takao / Hirata, Masahiro / Yoshizawa, Akihiko / Haga, Hironori / Nakaizumi, Akihiko. ·Department of Laboratory Medicine, Kyoto University Hospital, Kyoto 606-8507, Japan. af0106@kuhp.kyoto-u.ac.jp ·Rinsho Byori · Pubmed #22774571.

ABSTRACT: BACKGROUND: Endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) is a safe and effective method for obtaining samples for cytological diagnosis. Pancreatic cancer is extremely serious and often extremely aggressive, so early detection and diagnosis is important. Therefore, we actively perform EUS FNA for pathological diagnosis of cancer of digestive organs, especially the pancreas. MATERIALS AND METHODS: EUS-FNA was performed in 67 patients (39 male, 28 female, median age 63.3 years) from January 2007 to December 2010 in Kyoto University Hospital. To eliminate both quantitatively and qualitatively inadequate samples, we performed EUS-FNA with rapid on-site cytology. Two squash preparations of the collected cells from biopsy were retrieved. One was stained on-site with Giemsa for rapid cytology to evaluate the quantity and quality of the cell collection. If necessary, second or third trials were carried out to obtain appropriate samples for final cytology diagnosis. The other was wet-fixed and used for Papanicolaou staining. RESULTS: All 11 cases of inflammatory disease were diagnosed as negative on cytology. Solid-pseudopapillary neoplasm (1 case) and Endocrine neoplasms (3 cases) were correctly diagnosed on cytology. In pancreatic cancer, 49 of 52 cases (94%) were diagnosed as positive, but 3 cases (6%) were false-negative on cytology. The number of centesis for sampling was once in 21 cases, twice in 26 cases and more than twice in 20 cases. In this study of EUS-FNA, sensitivity was 94% and specificity was 100%. CONCLUSION: Results of our examination suggest that the combination of EUS-FNA and rapid on-site cytology is a highly specific and sensitive test for detection of pancreatic cancer, and may contribute to reduce excessive centesis.

5 Article Noninvasive intraductal papillary mucinous neoplasm with para-aortic lymph node metastasis: report of a case. 2011

Nagai, Kazuyuki / Doi, Ryuichiro / Koizumi, Masayuki / Masui, Toshihiko / Kawaguchi, Yoshiya / Yoshizawa, Akihiko / Uemoto, Shinji. ·Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University, Kyoto, Japan. ·Surg Today · Pubmed #21191709.

ABSTRACT: Intraductal papillary mucinous neoplasms (IPMNs) with an invasive carcinoma component are categorized as minimally invasive or invasive. The prognosis after resection of minimally invasive IPMNs has been reported to be similar to that after resection of noninvasive IPMNs. We report a case of noninvasive branchduct IPMN with multiple lymph node metastases, including para-aortic node involvement, treated successfully by distal pancreatectomy with lymph node dissection. The patient, a 72-year-old man, had two multilocular cysts in the pancreatic body, 22 mm and 14 mm in diameter, respectively, communicating with the main pancreatic duct. The primary tumor and nodal metastases had similar patterns of mucin expression. The primary tumor contained a region of carcinoma in situ (CIS) without histological evidence of stromal invasion; thus, it was diagnosed as minimally invasive carcinoma. We report this case to emphasize two important points: first, even small branch-duct IPMNs without any indications for resection can have a component of CIS or more advanced disease; and second, even branch-duct IPMNs without any apparent invasive component can be aggressive and spread to the lymph nodes. Therefore, nodal status should be assessed carefully in every patient, even if the primary IPMN is not advanced.

6 Article The distribution of atypical epithelium in main-duct type intraductal papillary mucinous neoplasms of the pancreas. 2011

Ito, Tatsuo / Doi, Ryuichiro / Yoshizawa, Akihiko / Sakikubo, Morito / Nagai, Kazuyuki / Kida, Atsushi / Koizumi, Masayuki / Masui, Toshihiko / Kawaguchi, Yoshiya / Manabe, Toshiaki / Uemoto, Shinji. ·Department of Surgery, Kyoto University, 54 Shogoinkawaracho, Sakyoku, Kyoto 606-8507, Japan. ·J Hepatobiliary Pancreat Sci · Pubmed #21165653.

ABSTRACT: BACKGROUND/PURPOSE: The purpose of this study was to obtain the fundamental data necessary to discuss the appropriate operative mode for the resection of main-duct type intraductal papillary mucinous neoplasms (mIPMNs) of the pancreas. METHODS: In 23 patients who underwent total pancreatectomy with preoperative and postoperative diagnoses of mIPMN, the imaging studies and clinicopathological data were collected. The whole pancreatic specimen was histologically evaluated, and the distribution of atypical epithelium was mapped on a schema. RESULTS: Pathological examination of the specimens revealed that 18 patients had carcinoma in the pancreas; 8 patients had invasive lesions and one patient had lymph node metastasis. Specimens from 5 patients did not bear carcinoma lesions but had widespread borderline lesions in the pancreas. The mapping of lesions in the pancreatic specimens revealed that, at least, borderline or higher lesions were present both in the head and distal pancreas in all patients. In the majority of the specimens, lesions from adenoma to carcinoma co-existed on the same slide, and there were normal cell intervals between the malignant lesions. CONCLUSION: We conclude that total pancreatectomy should be performed for mIPMN when dilatation of the main duct suggests possible spread of the lesion to the whole pancreas.

7 Minor Concomitant Case of Intraductal Papillary Mucinous Neoplasm of the Pancreas and Functioning Pancreatic Neuroendocrine Tumor (Vasoactive Intestinal Polypeptide-Producing Tumor): First Report. 2016

Ishizu, Shoko / Setoyama, Takeshi / Ueo, Taro / Ueda, Yoshihide / Kodama, Yuzo / Ida, Hiroshi / Kawaguchi, Yoshiya / Yoshizawa, Akihiko / Chiba, Tsutomu / Miyamoto, Shinʼichi. ·Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Kyoto, Japan Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Kyoto, Japan Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Kyoto, Japan Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Kyoto, Japan Division of Hepato-Biliary-Pancreatic and Transplant Surgery Department of Surgery Kyoto University Graduate School of Medicine Kyoto, Japan Department of Diagnostic Pathology Kyoto University Hospital Kyoto, Japan Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Kyoto, Japan shmiyamo@kuhp.kyoto-u.ac.jp. ·Pancreas · Pubmed #27295534.

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