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Pancreatic Neoplasms: HELP
Articles by D. Yang
Based on 3 articles published since 2010
(Why 3 articles?)

Between 2010 and 2020, D. Yang wrote the following 3 articles about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Article CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A. 2018

Tu, Q / Hao, J / Zhou, X / Yan, L / Dai, H / Sun, B / Yang, D / An, S / Lv, L / Jiao, B / Chen, C / Lai, R / Shi, P / Zhao, X. ·Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, China. · Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China. · State Key Laboratory of Genetic Resources and Evolution, Laboratory of Evolutionary and Functional Genomics, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China. · Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, China. · KIZ-SU Joint Laboratory of Animal Model and Drug Development, College of Pharmaceutical Sciences, Soochow University, Suzhou, China. ·Oncogene · Pubmed #28892048.

ABSTRACT: Pancreatic cancer is among the deadliest malignancies; however, the genetic events that lead to pancreatic carcinogenesis in adults remain unclear. In vivo models in which these genetic alterations occur in adult animals may more accurately reflect the features of human cancer. In this study, we demonstrate that inactivation of Cdkn2b (p15ink4b) is necessary for induction of pancreatic cancer by oncogenic KRAS

2 Article Pancreaticogastrostomy versus pancreaticojejunostomy after pancreaticoduodenectomy: a meta-analysis of randomized control trials. 2014

Chen, Z / Song, X / Yang, D / Li, Y / Xu, K / He, Y. ·Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. · Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. Electronic address: bigo_sysu@163.com. ·Eur J Surg Oncol · Pubmed #25079195.

ABSTRACT: BACKGROUND: Postoperative pancreatic fistula (PF) is the leading morbidity after pancreaticoduodenectomy (PD). The pancreatoenteric anastomosis method after PD is associated with the occurrence of PF. Evidence shows that pancreaticogastrostomy (PG) is possibly superior to pancreaticojejunostomy (PJ) in reducing the incidence of PF after PD; however, this remains to be definitively confirmed. METHODS: Randomized clinical trials (RCTs) comparing the outcomes of PG versus PJ after PD were retrieved for meta-analysis. RESULTS: After a thorough search of the English literature published until March 23rd, 2014, we identified seven RCTs involving 1095 patients (PG group, 548; PJ group, 547) for final analysis. Meta-analysis revealed that the incidence of PF was significantly lower in the PG group (15.7%) than in the PJ group (23.0%, 126/547; OR = 0.61, 95% CI: 0.45-0.83, P = 0.002). Furthermore, the incidence of intra-abdominal fluid collection was also lower in the PG group than in the PJ group (OR = 0.43, 95% CI: 0.28-0.65, P < 0.0001). No significant differences were found between the PG and PJ groups in terms of delayed gastric emptying, hemorrhage, overall morbidity and mortality. CONCLUSIONS: PG seemed to be superior to PJ in reducing the incidence of PF and intra-abdominal fluid collection after PD.

3 Article Expression profiles analysis of pancreatic cancer. 2013

Yang, D / Zhu, Z / Wang, W / Shen, P / Wei, Z / Wang, C / Cai, Q. ·Department of Gastrointestinal Surgery, Shanghai Changzheng Hospital affiliated to the Second Military Medical University, Shanghai, China. ·Eur Rev Med Pharmacol Sci · Pubmed #23426533.

ABSTRACT: BACKGROUND: [Corrected] Pancreatic cancer is the fourth most common cause of cancer-related deaths across the globe and has a poor prognosis. AIM: To investigate the characteristics of genomic expression profiles of pancreatic cancer and screen differentially expressed genes. MATERIALS AND METHODS: Using GSE16515 dataset downloaded from GEO (Gene Expression Omnibus) database, we first screened the differentially expressed genes (DEGs) in pancreatic cancer by packages in R language. The key functions of DEGs were investigated by GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis. The potential functionally important SNP (Single Nucleotide Polymorphism) was selected from the dbSNP database. RESULTS: A total of 1270 DEGs were identified. Most of them were predicted to be involved in pancreatic cancer development by sequence variant. Six genes (CDC42, STAT1, RALA, BCL2L1, TGFA, and EGF) were enriched in the known pancreatic cancer pathway. All these six genes had SNP, usually mutation at A/G and C/T point. CONCLUSIONS: Our results provide some underlying biomarkers for early diagnosis of pancreatic cancer.