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Pancreatic Neoplasms: HELP
Articles by Toshikazu Yamaguchi
Based on 1 article published since 2010
(Why 1 article?)

Between 2010 and 2020, Toshikazu Yamaguchi wrote the following article about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Article Long-term follow-up of chronic pancreatitis patients with K-ras mutation in the pancreatic juice. 2011

Kamisawa, Terumi / Takuma, Kensuke / Tabata, Taku / Egawa, Naoto / Yamaguchi, Toshikazu. ·Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan. kamisawa@cick.jp ·Hepatogastroenterology · Pubmed #21510309.

ABSTRACT: BACKGROUND/AIMS: Pancreatic cancer is known to occur during the course of chronic pancreatitis in some patients. This study aimed to identify a high risk group for developing pancreatic cancer associated with chronic pancreatitis, particularly the presence of K-ras mutations in the pancreatic juice. METHODOLOGY: K-ras mutation was analyzed by enriched polymerase chain reaction-enzyme linked mini-sequence assay in endoscopically-collected pancreatic juice of 21 patients with chronic pancreatitis between 1995 and 2000. All of them were followed-up for 6.0 +/- 3.8 (mean +/- SD) years (range, 2.1-14.2 years). RESULTS: K-ras point mutation was observed in the pancreatic juice of 11 patients with chronic pancreatitis (2+, n=2; 1+, n=6; +/-, n=3). Of these, 2 chronic pancreatitis patients with 2+K-ras point mutation developed pancreatic cancer 4.5 and 10.8 years, respectively, after the examination. CONCLUSIONS: Two chronic pancreatitis patients with K-ras mutation developed pancreatic cancer 4.5 and 10.8 years later. Semiquantitative analysis of K-ras mutation in endoscopically-collected pancreatic juice appears to be a useful tool for identifying chronic pancreatitis patients at high risk for developing pancreatic cancer.