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Pancreatic Neoplasms: HELP
Articles by K. Xu
Based on 4 articles published since 2010
(Why 4 articles?)
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Between 2010 and 2020, K. Xu wrote the following 4 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article [Comparison of laparoscopic distal pancreatectomy and open distal pancreatectomy in pancreatic ductal adenocarcinoma]. 2017

Xu, K / Su, J J / Su, M / Yan, L / Feng, J / Xin, X L / Chen, Y L. ·Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China. ·Zhonghua Zhong Liu Za Zhi · Pubmed #29061024.

ABSTRACT:

2 Article Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer. 2016

Zhang, S / Chung, W-C / Xu, K. ·Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA. · State Key Laboratory of Medical Genetics and School of Life Sciences, Central South University, Changsha, China. · Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, USA. ·Oncogene · Pubmed #26279302.

ABSTRACT: Notch controls pancreatic differentiation during development and is reactivated in pancreatic cancer. In recent years, the importance of Notch signaling in pancreatic tumorigenesis has become increasingly evident; however, it remains unclear how Notch activities are regulated in this context. Here we report differential regulation of Notch receptors by Lunatic Fringe (Lfng), which encodes an O-fucosylpeptide 3-β-N-acetylglucosaminyltransferase known to modify epidermal growth factor repeats in the Notch extracellular domain, during pathogenesis of Kras-induced pancreatic ductal adenocarcinoma (PDAC). We show that Lfng is uniquely expressed in a subset of acinar cells in the adult pancreas. Deletion of Lfng in the Kras(LSL-G12D/+);Pdx1-Cre mouse model caused increased activation of Notch3 throughout PDAC initiation and progression, and Notch1 after the onset of disease, associated with marked upregulation of Notch target gene Hes1. Deletion of Lfng also resulted in accumulation of Aldh1-positive cell population. We found that loss of Lfng significantly accelerated Kras-initiated PDAC development and shortened survival of the PDAC mice. Interestingly, Lfng-deficient tumors showed a propensity for a poorly differentiated state with features of epithelial-to-mesenchymal transition. Likewise, knockdown of LFNG in human PDAC cell lines caused elevated Notch activation, associated with either accelerated cell proliferation or expanded Aldh1-positive cell population. Deletion of Lfng resulted in downregulation of Tgfb1, Tgfb2 and Tgfbr2 expression in the wild-type pancreas at all ages examined, and in the Kras(LSL-G12D/+);Pdx1-Cre pancreas after PDAC onset, as well as reduced phospho-Smad2 levels in pancreatic tumors. We provide evidence that Lfng regulates transforming growth factor (TGF)-β signaling through Notch-mediated transcriptional repression of TGF-β pathway genes. Taken together, our results reveal a potent tumor-suppressive function for Lfng and crosstalk between Notch and TGF-β pathways in the pancreas, which provides new insight into initiation of PDAC and signals involved in disease progression.

3 Article Pancreaticogastrostomy versus pancreaticojejunostomy after pancreaticoduodenectomy: a meta-analysis of randomized control trials. 2014

Chen, Z / Song, X / Yang, D / Li, Y / Xu, K / He, Y. ·Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. · Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. Electronic address: bigo_sysu@163.com. ·Eur J Surg Oncol · Pubmed #25079195.

ABSTRACT: BACKGROUND: Postoperative pancreatic fistula (PF) is the leading morbidity after pancreaticoduodenectomy (PD). The pancreatoenteric anastomosis method after PD is associated with the occurrence of PF. Evidence shows that pancreaticogastrostomy (PG) is possibly superior to pancreaticojejunostomy (PJ) in reducing the incidence of PF after PD; however, this remains to be definitively confirmed. METHODS: Randomized clinical trials (RCTs) comparing the outcomes of PG versus PJ after PD were retrieved for meta-analysis. RESULTS: After a thorough search of the English literature published until March 23rd, 2014, we identified seven RCTs involving 1095 patients (PG group, 548; PJ group, 547) for final analysis. Meta-analysis revealed that the incidence of PF was significantly lower in the PG group (15.7%) than in the PJ group (23.0%, 126/547; OR = 0.61, 95% CI: 0.45-0.83, P = 0.002). Furthermore, the incidence of intra-abdominal fluid collection was also lower in the PG group than in the PJ group (OR = 0.43, 95% CI: 0.28-0.65, P < 0.0001). No significant differences were found between the PG and PJ groups in terms of delayed gastric emptying, hemorrhage, overall morbidity and mortality. CONCLUSIONS: PG seemed to be superior to PJ in reducing the incidence of PF and intra-abdominal fluid collection after PD.

4 Article Comparison of double contrast-enhanced ultrasound and MDCT for assessing vascular involvement of pancreatic adenocarcinoma: preliminary results correlated with surgical findings. 2012

Li, S / Huang, P / Xu, H / Xu, K / Wu, X. ·Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine. · Department of Ultrasonography, the 2nd Affiliated Hospital Zhejiang University College of Medicine. · Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine. ·Ultraschall Med · Pubmed #22549812.

ABSTRACT: PURPOSE: To investigate the accuracy of double contrast-enhanced ultrasound (DCEUS) for assessing vascular involvement by pancreatic adenocarcinoma. MATERIALS AND METHODS: 38 patients with pancreatic adenocarcinoma proven by postoperative pathology or biopsy were enrolled in this study. DCEUS (intravenous microbubbles combined with an oral contrast agent) and 16-row multi-detector CT (MDCT) were performed preoperatively to assess vascular invasion by pancreatic adenocarcinoma. The diagnostic accuracy of DCEUS and MDCT for assessing vascular involvement was calculated and compared. ROC curves were used to evaluate the diagnostic confidences of the two methods. The inter- and intra-observer reliability of DCEUS for assessing vascular invasion was investigated in the present study. RESULTS: Almost perfect agreement between DCEUS and MDCT was obtained using Kappa analysis (k = 0.83, p = 0.000). Compared with surgical findings, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of peripancreatic vascular invasion were 66.67 %, 100 %, 100 %, 60 %, and 77.78 %, respectively, for DCEUS and 75 %, 100 %, 100 %, 66.67 %, and 83.33 %, respectively, for MDCT. There was no significant difference in accuracy between DCEUS and MDCT for evaluating peripancreatic vascular invasion (p = 0.108). The combination of DCEUS and MDCT increased the diagnostic confidence in assessing peripancreatic vascular invasion with an area under ROC curve from 0.83 for DCEUS (p = 0.025) and 0.88 for MDCT (p = 0.011) to 0.92 for both combined (p = 0.005). The intra- and inter-observer reproducibility were both almost perfect for assessing the peripancreatic vascular invasion by DCEUS with a Kappa value of 0.94 (p = 0.000) for intra-observer and 0.83 (p = 0.000) for inter-observer. CONCLUSION: DCEUS could be considered as a reliable and accurate method for evaluating the peripancreatic vascular invasion of pancreatic adenocarcinoma.