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Pancreatic Neoplasms: HELP
Articles by Baoling Wang
Based on 1 article published since 2009
(Why 1 article?)

Between 2009 and 2019, Baoling Wang wrote the following article about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Article Direct TGF-β1 signaling between activated platelets and pancreatic cancer cells primes cisplatin insensitivity. 2013

Chen, Hongxu / Lan, Xiang / Liu, Menggang / Zhou, Bo / Wang, Baoling / Chen, Ping. ·Department of Hepatobiliary Surgery, Daping Hospital, The Third Military Medical University, 10 Changjiangzhilu Daping, Chongqing 400042, P.R., China. ·Cell Biol Int · Pubmed #23584798.

ABSTRACT: The exact mechanisms underlying chemotherapy insensitivity in pancreatic cancer remain largely unclear. The dynamic cross talk between tumors and their microenvironment is an important determinant of cancer chemosensitivity. However, whether additional signals provided during the intravascular transit of tumor cells affect the sensitivity of pancreatic cancer cells to chemotherapy is unknown. We have found that activated platelet-cancer cell interactions are sufficient to prime cisplatin (CDDP) insensitivity in pancreatic cancer cells. Activated platelet-derived TGF-β1 rather than direct platelet-tumor cell contacts stimulates PI3K/Akt and MEK/Erk signaling in pancreatic cancer cells, resulting in reduction of CDDP sensitivity in these cells. Therefore, the platelet-tumor cell interactions and the relevant signaling pathways that prime CDDP insensitivity may be potential targets for adjuvant chemotherapy for pancreatic cancer.