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Pancreatic Neoplasms: HELP
Articles by Eirini G. Velliou
Based on 3 articles published since 2010
(Why 3 articles?)
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Between 2010 and 2020, Eirini Velliou wrote the following 3 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Review Designing a bio-inspired biomimetic in vitro system for the optimization of ex vivo studies of pancreatic cancer. 2017

Totti, Stella / Vernardis, Spyros I / Meira, Lisiane / Pérez-Mancera, Pedro A / Costello, Eithne / Greenhalf, William / Palmer, Daniel / Neoptolemos, John / Mantalaris, Athanasios / Velliou, Eirini G. ·Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, University of Surrey, Guildford GU2 7XH, UK. · Biological Systems Engineering Laboratory (BSEL), Department of Chemical Engineering, Imperial College London, SW7 2AZ London, UK. · Department of Clinical and Experimental Medicine, University of Surrey, Guildford GU2 7XH, UK. · Department of Molecular and Clinical Cancer Medicine, University of Liverpool,Daulby Street, Liverpool L69 3GA, UK. · Department of Molecular and Clinical Cancer Medicine, University of Liverpool,Daulby Street, Liverpool L69 3GA, UK; NIHR Liverpool Pancreas Biomedical Research Unit, University of Liverpool,Daulby Street, Liverpool L69 3GA, UK. · NIHR Liverpool Pancreas Biomedical Research Unit, University of Liverpool,Daulby Street, Liverpool L69 3GA, UK. · Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, University of Surrey, Guildford GU2 7XH, UK. Electronic address: e.velliou@surrey.ac.uk. ·Drug Discov Today · Pubmed #28153670.

ABSTRACT: Pancreatic cancer is one of the most aggressive and lethal human malignancies. Drug therapies and radiotherapy are used for treatment as adjuvants to surgery, but outcomes remain disappointing. Advances in tissue engineering suggest that 3D cultures can reflect the in vivo tumor microenvironment and can guarantee a physiological distribution of oxygen, nutrients, and drugs, making them promising low-cost tools for therapy development. Here, we review crucial structural and environmental elements that should be considered for an accurate design of an ex vivo platform for studies of pancreatic cancer. Furthermore, we propose environmental stress response biomarkers as platform readouts for the efficient control and further prediction of the pancreatic cancer response to the environmental and treatment input.

2 Article Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering. 2018

Matta-Domjan, Brigitta / King, Alice / Totti, Stella / Matta, Csaba / Dover, George / Martinez, Patricia / Zakhidov, Anvar / La Ragione, Roberto / Macedo, Hugo / Jurewicz, Izabela / Dalton, Alan / Velliou, Eirini G. ·Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, Faculty of Engineering & Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK. · Department of Physics and Astronomy, School of Mathematical and Physical Sciences, University of Sussex, Brighton, BN1 9QH, UK. · Department of Veterinary Preclinical Sciences, School of Veterinary Science and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7AL, UK. · Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary. · Department of Physics, Faculty of Engineering & Physical Sciences, University of Surrey, Guildford, GU2 7XH, UK. · NanoTech Institute, University of Texas at Dallas, Richardson, Texas, 75083-068875080. · National University of Science and Technology, MISIS, Moscow, 119049, Russia. · Laboratory of Hybrid Nanophotonics and Optoelectronics, Department of Physics and Technology, ITMO University, St. Petersburg, 197101, Russia. · Department of Pathology and Infectious Diseases, School of Veterinary Science and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7AL, UK. · Smart Separations Ltd., London, UK. ·J Biomed Mater Res B Appl Biomater · Pubmed #28976640.

ABSTRACT: Novel synthetic biomaterials able to support direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi-walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds-which are easily tuneable to form sheets/fibers-support growth, proliferation, and spatial organization of pancreatic cancer cells, indicating their great potential in cancer tissue engineering. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1637-1644, 2018.

3 Article Sonodynamic therapy combined with novel anti-cancer agents, sanguinarine and ginger root extract: Synergistic increase in toxicity in the presence of PANC-1 cells in vitro. 2018

Prescott, Matthew / Mitchell, James / Totti, Stella / Lee, Judy / Velliou, Eirini / Bussemaker, Madeleine. ·Bioprocess and Biochemical Engineering (BioProChem) Group, Department of Chemical Engineering, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom. · Sonochemistry Ultrasonics Research Group (SURG), Department of Chemical Engineering, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom. · Sonochemistry Ultrasonics Research Group (SURG), Department of Chemical Engineering, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom. Electronic address: m.bussemaker@surrey.ac.uk. ·Ultrason Sonochem · Pubmed #28533126.

ABSTRACT: The presence of ultrasound-induced cavitation in sonodynamic therapy (SDT) treatments has previously enhanced the activity and delivery of certain sonosensitisers in biological systems. The purpose of this work was to investigate the potential for two novel anti-cancer agents from natural derivatives, sanguinarine and ginger root extract (GRE), as sonosensitisers in an SDT treatment with in vitro PANC-1 cells. Both anti-cancer compounds had a dose-dependent cytotoxicity in the presence of PANC-1 cells. A range of six discreet ultrasound power-frequency configurations were tested and it was found that the cell death caused directly by ultrasound was likely due to the sonomechanical effects of cavitation. Combined treatment used dosages of 100μM sanguinarine or 1mM of GRE with 15s sonication at 500kHz and 10W. The sanguinarine-SDT and GRE-SDT treatments showed a 6% and 17% synergistic increase in observed cell death, respectively. Therefore both sanguinarine and GRE were found to be effective sonosensitisers and warrant further development for SDT, with a view to maximising the magnitude of synergistic increase in toxicity.