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Pancreatic Neoplasms: HELP
Articles by Salvatore Vadala
Based on 3 articles published since 2009
(Why 3 articles?)

Between 2009 and 2019, S. Vadalà wrote the following 3 articles about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Article Prevalence of Extrapancreatic Malignancies Among Patients With Intraductal Papillary Mucinous Neoplasms of the Pancreas. 2018

Panic, Nikola / Macchini, Federico / Solito, Sonia / Boccia, Stefania / Leoncini, Emanuele / Larghi, Alberto / Berretti, Debora / Pevere, Sara / Vadala, Salvatore / Marino, Marco / Zilli, Maurizio / Bulajic, Milutin. ·Department for Gastroenterology and Digestive Endoscopy, Academic Center of Udine, Udine. · Section of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, IRCCS Fondazione Policlinico "Agostino Gemelli". · Digestive Endoscopy Unit, Catholic University, Rome, Italy. ·Pancreas · Pubmed #29771766.

ABSTRACT: OBJECTIVES: We conducted a study in order to assess the prevalence of extrapancreatic malignancies (EPMs) in a cohort of patients with intraductal papillary mucinous neoplasms (IPMNs) from northeastern Italy. METHODS: A study was conducted in hospital Santa Maria della Misericordia, Udine, Italy. Hospital records were screened in order to identify newly diagnosed IPMN cases in the period from January 1, 2009, to December 31, 2015. We searched for EPMs diagnosed previous to, synchronous to, or after the IPMN. The ratio of the observed (O) number of patients with EPMs to the expected (E) was calculated. RESULTS: We identified 72 EPMs in 63 (31.8%) of 198 patients included. Among them, 51 (70.8%) were diagnosed previous to, 17 (23.6%) synchronous to, and 4 (5.6%) after the IPMN. Most frequently diagnosed were colorectal (12 patients [6.1%]), breast (8 patients [6.8%, in females]), renal cell (8 patients [4.0%]), and prostate cancer (7 patients [8.6%, in males]). The O/E ratios for EPMs were significantly increased for cancer in general (3.66; 95% confidence interval [CI], 2.39-5.37), renal cell (9.62; 95% CI, 1.98-28.10), prostate (4.91; 95% CI, 1.59-11.45), and breast cancer (3.16; 95% CI, 1.03-7.37). CONCLUSIONS: We report an increased risk of EPMs in patients with IPMN, especially for renal cell, prostate, colorectal, and breast cancer.

2 Article Serous cystadenocarcinoma of the pancreas with portal thrombosis. 2010

Vadalà, S / Calderera, G / Cinardi, N / Manusia, M / Li Volti, G / Giannone, G. ·Service of Surgical Oncology, Department of Oncology, G.Garibaldi Hospital, Catania, Italy. ·Clin Ter · Pubmed #20499029.

ABSTRACT: Serous cystadenocarcinoma of the pancreas is a rare entity. We report on a primary tumor of the pancreas in a 74-year-old male. Computerized tomography showed an abdominal mass within pancreatic head, portal vein infiltration and absence of metastatic lesions. Patient underwent Whipple's procedure and portal vein thrombectomy. Pathologic examinations of the specimen showed it to be serous cystadenocarcinoma. To the knowledge of the authors, serous cystic neoplasms of the pancreas have been uniformly benign in biologic behaviour. However, serous cystadenocarcinoma of the pancreas has been reported as a new entity. The current report is the fi rst among 22 cases described to present portal vein thrombosis and might support the local malignant behaviour of this controversial class of tumours.

3 Article Distal pancreatectomy with en bloc resection of the celiac axis for pancreatic adenocarcinoma. 2009

Vadalà, S / Aronica, G / Biondi, A / Magnano, V / Valastro, M / Li Volti, G / Cordio, S / Giannone, G. ·Department of Oncology, Service of Surgical Oncology, University of Catania, Catania, Italy. ·Clin Ter · Pubmed #19795078.

ABSTRACT: Resection of celiac axis for gastric cancer was first performed by Appleby in 1953. Subsequently, Mayumi et al. and Kimura et al. adopted this approach for locally advanced adenocarcinoma of pancreatic body. We are here describing this technique in case of adenocarcinoma of pancreatic body with infiltration of celiac axis achieving also gastric preservation. Our patient presented with diabetes, back pain and weight loss. CT scan showed a 3 cm mass in the body of pancreas infiltrating the origin of celiac axis, causing obstructive atrophy of pancreatic tail. Bilirubin, transaminases, amylase and tumoral markers were in the normal range with the exception of CEA (34 ng/ml) and chromogranin (30 IU/l). Vascular reconstruction imaging indicated the feasibility of the procedure. Under intraoperative ultrasound guidance we clamped the common hepatic artery in order to check the gastric and hepatic blood flow. We then performed a distal pancreasectomy and splenectomy with "en bloc" resection of celiac axis and regional lymphadenectomy. Appleby operation can increase the resectability of locally advanced cancer of the body and tail of the pancreas and offers not only a better life quality for patients but also perfect pain relief. This technique demands a multidisciplinary approach with careful pre and intra operative vascular evaluation, which is mandatory in assessing candidacy for this procedure.