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Pancreatic Neoplasms: HELP
Articles by Maria Tretiakova
Based on 2 articles published since 2010
(Why 2 articles?)

Between 2010 and 2020, Maria Tretiakova wrote the following 2 articles about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Article Primary signet ring stromal tumor of the testis: a study of 13 cases indicating their phenotypic and genotypic analogy to pancreatic solid pseudopapillary neoplasm. 2017

Michalova, Kvetoslava / Michal, Michael / Kazakov, Dmitry V / Sedivcova, Monika / Hes, Ondrej / Hadravsky, Ladislav / Agaimy, Abbas / Tretiakova, Maria / Bacchi, Carlos / Hartmann, Arndt / Kuroda, Naoto / Bulimbasic, Stela / Coric, Marijana / Antic, Tatjana / Michal, Michal. ·Department of Pathology, Faculty of Medicine in Plzen, 30460, Charles University in Prague, 11636, Biopticka laborator s.r.o., Plzen, 30100, Czech Republic. Electronic address: kveta.michalova@biopticka.cz. · Department of Pathology, Faculty of Medicine in Plzen, 30460, Charles University in Prague, 11636, Biopticka laborator s.r.o., Plzen, 30100, Czech Republic; Biomedical Center, Faculty of Medicine in Plzen, 30460, Charles University, Czech Republic. · Department of Pathology, Faculty of Medicine in Plzen, 30460, Charles University in Prague, 11636, Biopticka laborator s.r.o., Plzen, 30100, Czech Republic. · Biopticka laborator s.r.o., Plzen, 30100, Czech Republic. · Department of Pathology, Charles University, 3rd Medical Faculty and Charles University Hospital Royal Vineyards, Prague, 10034, Czech Republic. · Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, 91054, Germany. · Department of Pathology, University of Washington, Seattle, 98195, USA. · Consultoria em Patologia, Botucatu, SP, 18602-010, Brazil. · Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, 780-8562, Japan. · Department of Pathology, University Hospital Centre, Zagreb, 100000, Croatia. · Department of Pathology, The University of Chicago, Chicago, 60637, USA. ·Hum Pathol · Pubmed #28739499.

ABSTRACT: Primary signet ring stromal tumor of the testis (PSRSTT) is an extremely rare tumor described only twice in the literature. Pancreatic-analogue solid pseudopapillary neoplasm (SPN) of the testis is a recently reported entity with morphological overlap with PSRSTT. We reviewed our files to find all cases of PSRSTT to better characterize this entity. We studied 13 cases of PSRSTTs using histological, immunohistochemical (IHC), and molecular genetic methods and compared the results with pancreatic SPN. Grossly, the size of PSRSTTs ranged from 0.5 to 2 cm (mean 1.1). Microscopically, PSRSTTs predominantly showed a proliferation of low-grade epithelioid cells containing characteristic cytoplasmic vacuole dislodging the nucleus (signet ring cells) separated by fibrous septa into trabeculae and nests. The immunoprofile was characterized by immunoreactivity for β-catenin, cyclin D1 (nuclear positivity for both antibodies), CD10, vimentin, galectin-3, claudin 7, α-1-antitrypsin, CD56, and neuron-specific enolase and negativity for chromogranin, inhibin, calretinin, SF-1, NANOG, OCT3/4, and SALL4. In some cases, the IHC panel was restricted because of a limited amount of tissue. Molecular genetic analysis revealed mutations within exon 3 of the CTNNB1 encoding β-catenin in all analyzable cases. Based on histological similarities between pancreatic SPN and PSRSTT and their identical IHC and molecular genetic features, we assume that both neoplasms share the same pathogenesis, and thus, PSRSTT can be considered as a testicular analogue of pancreatic SPN.

2 Article The expression of FOXL2 in pancreatic, hepatobiliary, and renal tumors with ovarian-type stroma. 2014

Westerhoff, Maria / Tretiakova, Maria / Hart, John / Gwin, Katja / Liu, Xiuli / Zhou, Ming / Yeh, Matthew M / Antic, Tatjana. ·University of Washington Medical Center, Seattle, WA 98195. Electronic address: mwest2@uw.edu. · University of Washington Medical Center, Seattle, WA 98195. · University of Chicago Medical Center, Chicago, IL 60637. · Cleveland Clinic, Cleveland, OH 809835. · New York University, New York, NY 10012. ·Hum Pathol · Pubmed #24746205.

ABSTRACT: FOXL2, a gene encoding a member of the fork-head-winged-helix family of transcription factors, is one of the earliest expressed genes during female gonadal development. It is expressed in normal ovarian stroma and ovarian neoplasms with granulosa cell lineage. Nonovarian tumors such as pancreatic mucinous cystic neoplasms (PMCs), hepatobiliary cystadenomas (HBCs), and mixed epithelial and stromal tumor of the kidney (MEST) have ovarian-type stroma. Immunohistochemical staining with FOXL2, estrogen receptor, and progesterone receptor was performed on 21 PMCs, 13 HBCs, and 10 MESTs and assessed for nuclear immunohistochemical positivity in the tumor stroma. All cases of PMC and HBC demonstrated nuclear reactivity for FOXL2 in the subepithelial stromal cells. Ninety percent of MEST demonstrated nuclear FOXL2 positivity. Estrogen receptor nuclear positivity was demonstrated in 57% of PMC, 77% of HBC, and 80% of MEST. Progesterone receptor nuclear positivity was present in 67% of PMC, 100% of HBC, and 90% of MEST. Clinical information was available for 37 patients. Seventy-eight percent of the patients had a history of obesity, heavy alcohol use, or hormone-related therapy. The 2 male patients had histories significant for morbid obesity and chronic alcoholism. FOXL2 is expressed from the early stages of ovarian development and has been shown to be mandatory for normal ovarian function. We have shown that it is also expressed in the aberrant ovarian-type stroma characteristic of PMC, HBC, and MEST. Most of such patients, including the rare male patients, have risk factors for hormonal abnormalities such as obesity and hormonal replacement therapy.