Pick Topic
Review Topic
List Experts
Examine Expert
Save Expert
  Site Guide ··   
Pancreatic Neoplasms: HELP
Articles by Ana Belen Tirado-Rodriguez
Based on 1 article published since 2010
(Why 1 article?)
||||

Between 2010 and 2020, Ana Belen Tirado-Rodriguez wrote the following article about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming. 2019

Koutsioumpa, Marina / Hatziapostolou, Maria / Polytarchou, Christos / Tolosa, Ezequiel J / Almada, Luciana L / Mahurkar-Joshi, Swapna / Williams, Jennifer / Tirado-Rodriguez, Ana Belen / Huerta-Yepez, Sara / Karavias, Dimitrios / Kourea, Helen / Poultsides, George A / Struhl, Kevin / Dawson, David W / Donahue, Timothy R / Fernández-Zapico, Martín E / Iliopoulos, Dimitrios. ·Center for Systems Biomedicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA. · Biological Sciences, University of Southampton, Southampton, UK. · Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK. · Interdisciplinary Biomedical Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK. · Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, Minnesota, USA. · Department of Surgery, Division of General Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA. · Unidad de Investigacion en Enfermedades Oncologicas, Hospital Infantil de Mexico, Mexico City, Mexico. · Department of Pathology, School of Medicine, University of Patras, Patras, Greece. · Department of Surgery, Stanford University School of Medicine, Stanford, California, USA. · Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA. · Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA. ·Gut · Pubmed #30337373.

ABSTRACT: OBJECTIVE: Despite advances in the identification of epigenetic alterations in pancreatic cancer, their biological roles in the pathobiology of this dismal neoplasm remain elusive. Here, we aimed to characterise the functional significance of histone lysine methyltransferases (KMTs) and demethylases (KDMs) in pancreatic tumourigenesis. DESIGN: DNA methylation sequencing and gene expression microarrays were employed to investigate CpG methylation and expression patterns of KMTs and KDMs in pancreatic cancer tissues versus normal tissues. Gene expression was assessed in five cohorts of patients by reverse transcription quantitative-PCR. Molecular analysis and functional assays were conducted in genetically modified cell lines. Cellular metabolic rates were measured using an XF24-3 Analyzer, while quantitative evaluation of lipids was performed by liquid chromatography-mass spectrometry (LC-MS) analysis. Subcutaneous xenograft mouse models were used to evaluate pancreatic tumour growth in vivo. RESULTS: We define a new antitumorous function of the histone lysine (K)-specific methyltransferase 2D (KMT2D) in pancreatic cancer. CONCLUSION: Together our findings define a new tumour suppressor function of KMT2D through the regulation of glucose/fatty acid metabolism in pancreatic cancer.