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Pancreatic Neoplasms: HELP
Articles by Takeshi Tanaka
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, Takeshi Tanaka wrote the following 2 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Significance of pancreatic calcification on preoperative computed tomography of intraductal papillary mucinous neoplasms. 2019

Tsujimae, Masahiro / Masuda, Atsuhiro / Shiomi, Hideyuki / Toyama, Hirochika / Sofue, Keitaro / Ueshima, Eisuke / Yamakawa, Kohei / Ashina, Shigeto / Yamada, Yasutaka / Tanaka, Takeshi / Tanaka, Shunta / Nakano, Ryota / Sato, Yu / Ikegawa, Takuya / Kurosawa, Manabu / Fujigaki, Seiji / Kobayashi, Takashi / Sakai, Arata / Kutsumi, Hiromu / Zen, Yoh / Itoh, Tomoo / Fukumoto, Takumi / Kodama, Yuzo. ·Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. · Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. · Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. · Center for Clinical Research and Advanced Medicine Establishment, Shiga University of Medical Science, Ōtsu, Shiga, Japan. · Division of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. ·J Gastroenterol Hepatol · Pubmed #31111533.

ABSTRACT: BACKGROUND AND AIM: Chronic pancreatitis is a risk factor for pancreatic cancer. Pancreatic calcification is a characteristic of chronic pancreatitis; however, its significance for intraductal papillary mucinous neoplasm (IPMN) oncogenesis remains unknown. Therefore, we investigated the relationship between pancreatic calcification and invasive IPMN. METHODS: This study included 157 patients who underwent resection for IPMN between April 2001 and October 2016 (intraductal papillary mucinous adenoma, n = 76; noninvasive intraductal papillary mucinous carcinoma [IPMC], n = 32; and invasive IPMC, n = 49). We divided the subjects on the basis of the presence/absence of pancreatic calcification on preoperative computed tomography (CT). The factors associated with pancreatic calcification were investigated in univariate analyses. Then, multivariate logistic regression analyses of the relationship between pancreatic calcification and invasive IPMC (after adjusting for clinical or imaging characteristics) were conducted. RESULTS: Preoperative CT revealed pancreatic calcification in 17.2% (27/157) of the resected IPMN. In the univariate analyses, jaundice, high serum carbohydrate antigen 19-9 levels, and invasive IPMC were significantly associated with pancreatic calcification (4/27 [14.8%] vs 4/130 [3.1%], 0.01; 12/27 [44.4%] vs 31/130 [23.8%], 0.03; and 15/27 [55.6%] vs 34/130 [26.2%], 0.001, respectively). Pancreatic calcification was significantly associated with invasive IPMC (multivariate odds ratio = 2.88, 95% confidence interval [95% CI] = 1.15-7.21, 0.03, adjusted for clinical characteristics; odds ratio = 5.50, 95% CI = 1.98-15.3, 0.001, adjusted for imaging characteristics). CONCLUSIONS: Pancreatic calcification on CT is associated with invasive IPMC. Pancreatic calcification might be a predictor of invasive IPMC.

2 Article Evaluation of efficacy of pancreatic juice cytology for risk classification according to international consensus guidelines in patients with intraductal papillary mucinous neoplasm; a retrospective study. 2019

Yamakawa, Kohei / Masuda, Atsuhiro / Nakagawa, Takashi / Shiomi, Hideyuki / Toyama, Hirochika / Takenaka, Mamoru / Sakai, Arata / Kobayashi, Takashi / Tsujimae, Masahiro / Ashina, Shigeto / Yamada, Yasutaka / Tanaka, Takeshi / Tanaka, Shunta / Nakano, Ryota / Sato, Yu / Ikegawa, Takuya / Kurosawa, Manabu / Fujigaki, Seiji / Kutsumi, Hiromu / Itoh, Tomoo / Fukumoto, Takumi / Kodama, Yuzo. ·Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. · Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. Electronic address: atmasuda@med.kobe-u.ac.jp. · Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. · Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Sayama, Osaka, Japan. · Center for Clinical Research and Advanced Medicine Establishment, Shiga University of Medical Science, Japan. · Division of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. ·Pancreatology · Pubmed #30857854.

ABSTRACT: OBJECTIVES: Pancreatic juice cytology (PJC) for intraductal papillary mucinous neoplasm (IPMN) is a possible tool to enhance preoperative diagnostic ability by improving risk classification for malignant IPMN, but its efficacy is controversial. This study evaluated the efficacy of PJC for risk classification according to international guidelines. METHODS: We retrospectively analyzed 127 IPMN patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) preoperatively. PJC was performed in 125 of the 127 cases. High-risk stigmata (HRS, n = 57), worrisome features (WF, n = 64), and other characteristics (n = 6) were classified according to the 2017 international guidelines. RESULTS: Among the 127 IPMN patients, 71 (55.9%) had malignant IPMN (invasive and non-invasive intraductal papillary mucinous carcinoma). The accuracy of WF for classifying malignant IPMN was increased by the addition of PJC, but the accuracy of HRS was not (WF to WF + PJC: 33.1% [42/127] to 48.8% [61/125], HRS to HRS + PJC: 65.4% [83/127] to 52.8% [66/125]). Post-ERCP pancreatitis (PEP) occurred in 32 (25.2%) of 127 IPMN patients. Severe PEP was not detected. Significant risk factors for PEP were female sex, obesity, and endoscopic naso-pancreatic drainage (ENPD) (P = .03, P = .0006, and P = .02, respectively). In patients with ENPD tube placement, a main pancreatic duct size of <5 mm was a significant risk factor for PEP (P = .02). CONCLUSION: PJC could increase the accuracy of WF for classifying malignant IPMN. The additive effect of PJC for risk classification may be limited, however, and it is not recommended for all IPMN cases due to the high frequency of PEP.