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Pancreatic Neoplasms: HELP
Articles by Reina Tanaka
Based on 10 articles published since 2010
(Why 10 articles?)
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Between 2010 and 2020, Reina Tanaka wrote the following 10 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Review [The strategy of pancreatic cancer for early detection]. 2015

Sofuni, Atsushi / Itoi, Takao / Tsuchiya, Takayoshi / Tsuji, Shujiro / Kamada, Kentaro / Ikeuchi, Nobuhito / Tanaka, Reina / Umeda, Junko / Tonozuka, Ryosuke / Honjo, Mitsuyoshi / Mukai, Shuntaro / Fujita, Mitsuru / Yamamoto, Kenjiro / Moriyasu, Fuminori. ·Department of Gastroenterology and Hepatology, Tokyo Medical University. ·Nihon Shokakibyo Gakkai Zasshi · Pubmed #26250128.

ABSTRACT: -- No abstract --

2 Clinical Trial Multicenter, prospective, crossover trial comparing the door-knocking method with the conventional method for EUS-FNA of solid pancreatic masses (with videos). 2016

Mukai, Shuntaro / Itoi, Takao / Ashida, Reiko / Tsuchiya, Takayoshi / Ikeuchi, Nobuhito / Kamada, Kentaro / Tanaka, Reina / Umeda, Junko / Tonozuka, Ryosuke / Fukutake, Nobuyasu / Hoshi, Koki / Moriyasu, Fuminori / Gotoda, Takuji / Irisawa, Atsushi. ·Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan. · Department of Hepatobiliary and Pancreato-oncology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan. · Department of Gastroenterology, Fukushima Medical University Aizu Medical Center, Aizuwakamatsu, Japan. ·Gastrointest Endosc · Pubmed #26522372.

ABSTRACT: BACKGROUND AND AIMS: There are currently no prospective, controlled trials of needle puncture speed in EUS-guided FNA (EUS-FNA). In this study, we prospectively evaluated the accuracy of histological diagnosis and the tissue acquisition rate of EUS-FNA by using the door-knocking method (DKM) with a standard 22-gauge needle. METHODS: From November 2013 to August 2014, 82 patients who had solid pancreatic masses underwent EUS-FNA in which the conventional method (CM) and DKM with 2 respective passes in turn were used. The primary outcomes of this study were the accuracy of histological diagnosis and the rates of tissue acquisition in 2 FNA procedures by using these 2 methods. RESULTS: Although the successful tissue acquisition rate for histology was not significantly different with the DKM and CM (91.5% vs 89.0%, P = .37), the high cellularity tissue acquisition rate for histology with the DKM was significantly superior to that with the CM (54.9% vs 41.5%, P = .03). However, adequate quality rate and accuracy were not different in the DKM and CM (78.0% vs 80.5%, P = .42 and 76.8% vs 78.0%, P = .50, respectively). In the transgastric puncture group, although the adequate quality rate and accuracy were similar in the DKM and CM (84.1% vs 79.4%, P = .30 and 84.1% vs 76.2%, P = .11, respectively), the tissue acquisition rate tended to be higher with the DKM than the CM (93.7% vs 85.7%, P = .06). Moreover, the high cellularity tissue acquisition rate was significantly better with the DKM than the CM (63.5% vs 39.7%, P = .002). On the other hand, in the transduodenal puncture group, although the tissue acquisition rate was similar with the DKM and CM (84.2% vs 100%, P = .13), the adequate quality rate and accuracy were significantly lower with the DKM than with the CM (57.9% vs 84.2%, P = .03 and 52.6% vs 84.2%, P = .02, respectively). CONCLUSION: EUS-FNA by using a 22-gauge needle with the DKM did not improve the accuracy of histological diagnosis, but enabled acquisition of a larger amount of tissue specimen by using transgastric puncture. ( TRIAL REGISTRATION: http://www.umin.ac.jp/english/: UMIN000012127.).

3 Clinical Trial Safety trial of high-intensity focused ultrasound therapy for pancreatic cancer. 2014

Sofuni, Atsushi / Moriyasu, Fuminori / Sano, Takatomo / Itokawa, Fumihide / Tsuchiya, Takayoshi / Kurihara, Toshio / Ishii, Kentaro / Tsuji, Syujiro / Ikeuchi, Nobuhito / Tanaka, Reina / Umeda, Junko / Tonozuka, Ryosuke / Honjo, Mitsuyoshi / Mukai, Shuntaro / Fujita, Mitsuru / Itoi, Takao. ·Atsushi Sofuni, Fuminori Moriyasu, Takatomo Sano, Fumihide Itokawa, Takayoshi Tsuchiya, Toshio Kurihara, Kentaro Ishii, Syujiro Tsuji, Nobuhito Ikeuchi, Reina Tanaka, Junko Umeda, Ryosuke Tonozuka, Mitsuyoshi Honjo, Shuntaro Mukai, Mitsuru Fujita, Takao Itoi, Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo 160-0023, Japan. ·World J Gastroenterol · Pubmed #25071354.

ABSTRACT: AIM: To evaluate the safety and clinical application of high-intensity focused ultrasound (HIFU) therapy for unresectable pancreatic cancer (PC). METHODS: Thirty PC patients (16 cases in stage III and 14 cases in stage IV) with visualized pancreatic tumors were admitted for HIFU therapy as an optional local therapy in addition to systemic chemotherapy or chemoradiotherapy. Informed consent was obtained. This study began at the end of 2008 and was approved by the ethics committee of our hospital [Institutional Review Board (IRB): 890]. The HIFU device used was the FEP-BY02 (Yuande Bio-Medical Engineering, Beijing, China). RESULTS: The mean tumor size after HIFU therapy changed to 30.9 ± 1.7 mm from 31.7 ± 1.7 mm at pre-therapy. There were no significant changes in tumor size, mean number of treatment sessions (2.7 ± 0.1 mm), or mean total treatment time (2.4 ± 0.1 h). The rate of symptom relief effect was 66.7%. The effectiveness of primary lesion treatment was as follows: complete response, 0; partial response, 4; stable disease, 22; progressive disease, 4. Treatment after HIFU therapy included 2 operations, 24 chemotherapy treatments, and 4 best supportive care treatments. Adverse events occurred in 10% of cases, namely pseudocyst formation in 2 cases and mild pancreatitis development in 1. However, no severe adverse events occurred in this study. CONCLUSION: We suggest that HIFU therapy is safe and has the potential to be a new method of combination therapy for PC.

4 Article A retrospective histological comparison of EUS-guided fine-needle biopsy using a novel franseen needle and a conventional end-cut type needle. 2019

Mukai, Shuntaro / Itoi, Takao / Yamaguchi, Hiroshi / Sofuni, Atsushi / Tsuchiya, Takayoshi / Tanaka, Reina / Tonozuka, Ryosuke / Honjo, Mitsuyoshi / Fujita, Mitsuru / Yamamoto, Kenjiro / Matsunami, Yukitoshi / Asai, Yasutsugu / Kurosawa, Takashi / Nagakawa, Yuichi. ·Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan. · Division of Diagnostic Pathology, Tokyo Medical University, Tokyo, Japan. · Third Department of Surgery, Tokyo Medical University, Tokyo, Japan. ·Endosc Ultrasound · Pubmed #29786033.

ABSTRACT: Background and Objectives: Recently, a 22G Franseen needle for EUS-guided fine-needle biopsy (EUS-FNB) with three novel symmetric heels has been developed to adequately obtain a core tissue. Methods: All 38 consecutive patients with pancreatic masses who underwent EUS-FNB using a Franseen needle were investigated retrospectively to assess the efficacy and safety of EUS-FNB using the Franseen needle. Then, the EUS-FNB outcomes and histological assessments of the tissue obtained by EUS-FNB using the Franseen needle and EUS-FNA using the conventional end-cut type needle for each of the 30 pancreatic ductal adenocarcinoma cases were compared. Results: An accurate histological diagnosis of the Franseen needle was achieved with a mean of 2 passes in 97.4% of patients. Although the accurate histological diagnosis rate of pancreatic ductal adenocarcinoma was not significantly different (96.7% vs. 93.3%, P = 0.55), the mean number of passes in the Franseen needle was significantly less than that in the conventional needle (2.1 ± 0.4 vs. 3.2 ± 0.8, P < 0.001). The presence of desmoplastic fibrosis with neoplastic cellular elements and venous invasion were significantly higher (96.7% vs. 40.0%, P < 0.001 and 23.3% vs. 0%, P < 0.01, respectively) and the amount of obtained tissue was significantly larger with the Franseen needle (2.13 mm Conclusions: EUS-FNB using the Franseen needle enables the acquisition of a larger amount of tissue sample and achieves an accurate histological diagnosis with a smaller number of passes than the conventional end-cut type needle.

5 Article Elevated Polyamines in Saliva of Pancreatic Cancer. 2018

Asai, Yasutsugu / Itoi, Takao / Sugimoto, Masahiro / Sofuni, Atsushi / Tsuchiya, Takayoshi / Tanaka, Reina / Tonozuka, Ryosuke / Honjo, Mitsuyoshi / Mukai, Shuntaro / Fujita, Mitsuru / Yamamoto, Kenjiro / Matsunami, Yukitoshi / Kurosawa, Takashi / Nagakawa, Yuichi / Kaneko, Miku / Ota, Sana / Kawachi, Shigeyuki / Shimazu, Motohide / Soga, Tomoyoshi / Tomita, Masaru / Sunamura, Makoto. ·Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. yacchan85@yahoo.co.jp. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. itoi@tokyo-med.ac.jp. · Research and Development Center for Minimally Invasive Therapies Health Promotion and Preemptive Medicine, Tokyo Medical University, Shinjuku, Tokyo 160-8402, Japan. mshrsgmt@tokyo-med.ac.jp. · Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan. mshrsgmt@tokyo-med.ac.jp. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. a-sofuni@amy.hi-ho.ne.jp. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. tsuchiya623@mac.com. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. onakasuicyatta@yahoo.co.jp. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. tonozuka1978@gmail.com. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. 3244honjo@gmail.com. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. maezora1031@yahoo.co.jp. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. fujita.com.com@gmail.com. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. kenjirojiro5544@yahoo.co.jp. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. yukitoshimatsunami1228@yahoo.co.jp. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. takasikurosawa716@yahoo.co.jp. · Third Department of Surgery, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. KKK-miku@ttck.keio.ac.jp. · Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan. sana.ota@ttck.keio.ac.jp. · Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan. soga@sfc.keio.ac.jp. · Fourth Department of Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo 190-0998, Japan. skawachi@tokyo-med.ac.jp. · Fourth Department of Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo 190-0998, Japan. mt@sfc.keio.ac.jp. · Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan. naga@tokyo-med.ac.jp. · Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan. shimazu2401@yahoo.co.jp. · Fourth Department of Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo 190-0998, Japan. be7@xui.biglobe.ne.jp. ·Cancers (Basel) · Pubmed #29401744.

ABSTRACT: Detection of pancreatic cancer (PC) at a resectable stage is still difficult because of the lack of accurate detection tests. The development of accurate biomarkers in low or non-invasive biofluids is essential to enable frequent tests, which would help increase the opportunity of PC detection in early stages. Polyamines have been reported as possible biomarkers in urine and saliva samples in various cancers. Here, we analyzed salivary metabolites, including polyamines, using capillary electrophoresis-mass spectrometry. Salivary samples were collected from patients with PC (

6 Article Evaluation of novel slim biopsy forceps for diagnosis of biliary strictures: Single-institutional study of consecutive 360 cases (with video). 2017

Yamamoto, Kenjiro / Tsuchiya, Takayoshi / Itoi, Takao / Tsuji, Shujiro / Tanaka, Reina / Tonozuka, Ryosuke / Honjo, Mitsuyoshi / Mukai, Shuntaro / Kamada, Kentaro / Fujita, Mitsuru / Asai, Yasutsugu / Matsunami, Yukitoshi / Nagakawa, Yuichi / Yamaguchi, Hiroshi / Sofuni, Atsushi. ·Department of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan. · Department of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan. itoi@tokyo-med.ac.jp. · Third Department of Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan. · Department of Pathology, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan. ·World J Gastroenterol · Pubmed #29085192.

ABSTRACT: AIM: To evaluate the feasibility and reliability of endoscopic transpapillary bile duct biopsy for the diagnosis of biliary strictures. METHODS: A total of 360 patients (241 men) who underwent endoscopic retrograde cholangiopancreatography for biliary strictures with biopsy from April 2012 to March 2016 at Tokyo Medical University Hospital were retrospectively reviewed. This study was approved by our Institutional Review Board (No. 3516). Informed consent was obtained from all individual participants included in this study. The biopsy specimens were obtained using a novel slim biopsy forceps (Radial Jaw 4P, Boston Scientific, Boston, MA, United States). RESULTS: The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 69.6%, 100%, 100%, 59.1%, and 78.8%, respectively. The sensitivity was 75.6% in bile duct cancer, 64% in pancreatic cancer, 61.1% in gallbladder cancer, and 57.1% in metastasis. In bile duct cancer, a lower sensitivity was observed for perihilar bile duct stricture (68.7%) than for distal bile duct stricture (83.1%). In terms of the stricture lengths of pancreatic cancer, gallbladder cancer, and metastasis, a longer stenosis resulted in a better sensitivity. In particular, there was a significant difference between pancreatic cancer and gallbladder cancer ( CONCLUSION: Endoscopic transpapillary biopsy alone using novel slim biopsy forceps is feasible and reliable, but restrictive. Biopsy should be performed in consideration of the stricture level, stricture length, and cancer type.

7 Article Serum Metabolomic Profiles for Human Pancreatic Cancer Discrimination. 2017

Itoi, Takao / Sugimoto, Masahiro / Umeda, Junko / Sofuni, Atsushi / Tsuchiya, Takayoshi / Tsuji, Shujiro / Tanaka, Reina / Tonozuka, Ryosuke / Honjo, Mitsuyoshi / Moriyasu, Fuminori / Kasuya, Kazuhiko / Nagakawa, Yuichi / Abe, Yuta / Takano, Kimihiro / Kawachi, Shigeyuki / Shimazu, Motohide / Soga, Tomoyoshi / Tomita, Masaru / Sunamura, Makoto. ·Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. itoi@tokyo-med.ac.jp. · Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan. msugi@sfc.keio.ac.jp. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. junko.umeda@gmail.com. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. a-sofuni@amy.hi-ho.ne.jp. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. tsuchiya623@mac.com. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. g.shujiro@gmail.com. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. onakasuicyatta@yahoo.co.jp. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. tonozuka1978@gmail.com. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. honjo3244@yahoo.co.jp. · Division of Gastroenterology and Hepatology, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. moriyasu@tokyo-med.ac.jp. · Third Department of Surgery, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. kasuya-k@jcom.home.ne.jp. · Third Department of Surgery, Tokyo Medical University, Shinjuku, Tokyo 160-0023, Japan. naga@tokyo-med.ac.jp. · Fourth Department of Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji,Tokyo 193-0998, Japan. abey3666@gmail.com. · Fourth Department of Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji,Tokyo 193-0998, Japan. kiminoriman526@yahoo.co.jp. · Fourth Department of Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji,Tokyo 193-0998, Japan. skawachi@tokyo-med.ac.jp. · Fourth Department of Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji,Tokyo 193-0998, Japan. shimazu2401@yahoo.co.jp. · Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan. soga@sfc.keio.ac.jp. · Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan. mt@sfc.keio.ac.jp. · Fourth Department of Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji,Tokyo 193-0998, Japan. be7@xui.biglobe.ne.jp. ·Int J Mol Sci · Pubmed #28375170.

ABSTRACT: This study evaluated the clinical use of serum metabolomics to discriminate malignant cancers including pancreatic cancer (PC) from malignant diseases, such as biliary tract cancer (BTC), intraductal papillary mucinous carcinoma (IPMC), and various benign pancreaticobiliary diseases. Capillary electrophoresismass spectrometry was used to analyze charged metabolites. We repeatedly analyzed serum samples (

8 Article New digital cholangioscopy-guided removal of a transpapillary plastic stent through the hepaticogastrostomy route. 2016

Tanaka, Reina / Mukai, Shuntaro / Itoi, Takao / Honjo, Mitsuyoshi / Tsuchiya, Takayoshi. ·Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan. ·Gastrointest Endosc · Pubmed #26989040.

ABSTRACT: -- No abstract --

9 Article Endoscopic ultrasonography-guided cholecystogastrostomy using a lumen-apposing metal stent as an alternative to extrahepatic bile duct drainage in pancreatic cancer with duodenal invasion. 2013

Itoi, Takao / Binmoeller, Kenneth / Itokawa, Fumihide / Umeda, Junko / Tanaka, Reina. ·Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan. itoi@tokyo-med.ac.jp ·Dig Endosc · Pubmed #23617665.

ABSTRACT: Various approaches to biliary drainage, especially endoscopic ultrasonography (EUS)-guided drainage, have become commonly used as an alternative method for biliary decompression for malignant biliary obstruction. Occasionally, however, duodenal obstruction and non-dilated intrahepatic bile duct impede conventional EUS-guided biliary drainage. Herein, we describe a case of cholecystogastrostomy successfully carried out using a newly developed fully covered lumen-apposing self-expandable metallic stent (SEMS). EUS-guided cholecystogastrostomy should be considered an option for biliary decompression. This is a particularly ideal alternative if the patient has duodenal strictures with or without a duodenal metal stent and a non-dilated intrahepatic bile duct, which suggests the impossibility of choledochoduodenostomy and hepaticogastrostomy. Furthermore, the newly developed fully covered lumen-apposing SEMS seems ideal for EUS-guided cholecystoenterostomy.

10 Article EUS elastography combined with the strain ratio of tissue elasticity for diagnosis of solid pancreatic masses. 2011

Itokawa, Fumihide / Itoi, Takao / Sofuni, Atsushi / Kurihara, Toshio / Tsuchiya, Takayoshi / Ishii, Kentaro / Tsuji, Shujiro / Ikeuchi, Nobuhito / Umeda, Junko / Tanaka, Reina / Yokoyama, Naoyuki / Moriyasu, Fuminori / Kasuya, Kazuhiko / Nagao, Toshitaka / Kamisawa, Terumi / Tsuchida, Akihiko. ·Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. ·J Gastroenterol · Pubmed #21505859.

ABSTRACT: BACKGROUND: Recently, the usefulness of endoscopic ultrasound (EUS) elastography has been reported for the diagnosis of pancreatic lesions. In the present study, we retrospectively assessed EUS elastography as a diagnostic tool by evaluating tissue elasticity distribution and elasticity semiquantification, using the strain ratio (SR) of tissue elasticity, in patients with pancreatic masses. METHODS: One hundred and nine patients who underwent EUS elastography between September 2006 and May 2009 were retrospectively evaluated. The final diagnosis was chronic pancreatitis (CP) in 20 patients [6 with non-mass-forming pancreatitis, 7 with mass-forming pancreatitis (MFP), and 7 with autoimmune pancreatitis (AIP)], pancreatic cancer (PC) in 72, pancreatic neuroendocrine tumor (PNET) in 9, and normal pancreas in 8. The tissue elasticity distribution calculation was performed in real time, and the results were represented in color in fundamental B-mode imaging. In addition, we performed quantification using the SR (non-mass area/mass area). RESULTS: Elastography for all PC patients showed intense blue coloration, indicating malignant lesions. In contrast, MFP presented with a mixed coloration pattern of green, yellow, and low-intensity blue. Normal controls showed an even distribution of green to red. The mean SR was 23.66 ± 12.65 for MFP and 39.08 ± 20.54 for PC (P < 0.05). CONCLUSIONS: Endoscopic ultrasound elastography is a promising diagnostic tool for defining the tissue characteristics of pancreatic masses. In addition, semiquantitative analysis of elasticity using the SR may allow the differentiation of MFP from PC.