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Pancreatic Neoplasms: HELP
Articles by Tsuyoshi Tajima
Based on 5 articles published since 2008
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Between 2008 and 2019, Tsuyoshi Tajima wrote the following 5 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Guideline Validation of the American Gastroenterological Association guidelines on management of intraductal papillary mucinous neoplasms: more than 5 years of follow-up. 2018

Imbe, Koh / Nagata, Naoyoshi / Hisada, Yuya / Takasaki, Yusuke / Sekine, Katsunori / Mishima, Saori / Kawazoe, Akihito / Tajima, Tsuyoshi / Shimbo, Takuro / Yanase, Mikio / Akiyama, Junichi / Fujimoto, Kazuma / Uemura, Naomi. ·Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo, 162-8655, Japan. · Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo, 162-8655, Japan. nnagata_ncgm@yahoo.co.jp. · Department of Gastrointestinal Oncology, National Cancer Center East Hospital, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. · Departments of Diagnostic Radiology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo, 162-8655, Japan. · Ohta Nishinouchi Hospital, 2-5-20 Nishinouchi, Koriyama city, Fukushima, 963-8558, Japan. · Department of Internal Medicine & Gastrointestinal Endoscopy, Faculty of Medicine, Saga University, 1 Honjo-machi, 840-8502, Saga, Japan. · Department of Gastroenterology and Hepatology, Kohnodai Hospital, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa, 272-8516, Chiba, Japan. ·Eur Radiol · Pubmed #28770404.

ABSTRACT: OBJECTIVES: Recent guidelines suggest that imaging surveillance be conducted for 5 years for patients with at most one high-risk feature. If there were no significant changes, surveillance is stopped. We sought to validate this follow-up strategy. METHODS: In study 1, data were analysed for 392 patients with intraductal papillary mucinous neoplasms (IPMNs) and at most one high-risk feature who were periodically followed up for more than 1 year with imaging tests. In study 2, data were analysed for 159 IPMN patients without worsening high-risk features after 5 years (stop surveillance group). RESULTS: In study 1, pancreatic cancer (PC) was identified in 12 patients (27.3%) in the endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) indication group and none in the non-EUS-FNA indication group (P < 0.01). In the EUS-FNA indication group, 11 patients (25%) died, whereas 29 (8.3%) died in the non EUS-FNA indication group (P < 0.01). In study 2 (stop surveillance group), PC was identified in three patients (1.9%) at 84, 103 and 145 months. CONCLUSIONS: PC risk and mortality for IPMNs not showing significant change for 5 years is likely to be low, and the non-EUS-FNA indication can provide reasonable decisions. However, three patients without worsening high-risk features for 5 years developed PC. The stop surveillance strategy should be reconsidered. KEY POINTS: • The AGA guidelines provide reasonable clinical decisions for the EUS-FNA indication. • In stop surveillance group, PC was identified in 3 patients (1.9%). • In stop surveillance group, 2 of 3 PC patients died from PC. • Risk of pancreatic cancer in "stop surveillance" group is not negligible.

2 Article Natural history of intraductal papillary mucinous neoplasm and non-neoplastic cyst: long-term imaging follow-up study. 2017

Hisada, Yuya / Nagata, Naoyoshi / Imbe, Koh / Takasaki, Yusuke / Sekine, Katsunori / Tajima, Tsuyoshi / Yanase, Mikio / Fujimoto, Kazuma / Akiyama, Junichi / Uemura, Naomi. ·Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan. · Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan. · Department of Gastroenterology, Saga Medical School, Saga, Japan. · Kohnodai Hospital, Chiba, Japan. ·J Hepatobiliary Pancreat Sci · Pubmed #28512773.

ABSTRACT: BACKGROUND: To identify differences in incidence and mortality of pancreatic cancer (PC) between intraductal papillary mucinous neoplasm (IPMN) and non-neoplastic cyst. METHODS: Patients with pancreatic cyst (n = 526; 263 with IPMN and 263 with non-neoplastic cyst matched for age, sex, and diagnosis year) were periodically followed-up with imaging. Hazard ratio (HR), standardized incidence ratio (SIR), and standardized mortality ratio (SMR) for PC and PC-related mortality were estimated. RESULTS: During a mean follow-up of 57.5 months with 3,376 computed tomography scans and 1,079 magnetic resonance imaging scans, 5-year cumulative PC incidence was 4.0% for IPMN and 0% for non-neoplastic cyst, respectively (HR 5.2; P = 0.031). During a mean follow-up of 73.1 months, 5-year cumulative PC-related mortality was 2.6% for IPMN and 0% for non-neoplastic cyst, respectively (HR 4.5; P = 0.05). Compared with the general population in Japan, patients with IPMN, but not those with non-neoplastic cyst, had significantly increased risks of PC incidence (SIR 22.03) and related mortality (SMR 15.9). CONCLUSIONS: During long-term imaging follow-up, patients with IPMN developed PC over time, whereas none of the patients with non-neoplastic cyst developed it within 5 years. Compared with the general population, patients with IPMN, but not those with non-neoplastic cyst, were at risk of PC and related mortality.

3 Article Differential diagnosis of groove pancreatic carcinomas vs. groove pancreatitis: usefulness of the portal venous phase. 2010

Ishigami, Kousei / Tajima, Tsuyoshi / Nishie, Akihiro / Kakihara, Daisuke / Fujita, Nobuhiro / Asayama, Yoshiki / Ushijima, Yasuhiro / Irie, Hiroyuki / Nakamura, Masafumi / Takahata, Shunichi / Ito, Tetsuhide / Honda, Hiroshi. ·Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Ishigamikousei@aol.com ·Eur J Radiol · Pubmed #19450943.

ABSTRACT: PURPOSE: To clarify if the portal venous phase is helpful for the differential diagnosis of groove pancreatic carcinomas and groove pancreatitis. MATERIALS AND METHODS: MDCT and MRI of groove pancreatic carcinomas (n=7) and groove pancreatitis (n=15) were retrospectively reviewed by two radiologists independently. The signal intensity on T2-weighted images was subjectively assessed. The presence or absence of common bile duct (CBD) and main pancreatic duct (MPD) strictures, calcifications, and cystic lesions was evaluated. Additionally, the appearance of groove pancreatic carcinoma and that of groove pancreatitis in the portal venous phase on dynamic MDCT and MRI were compared. RESULTS: There were no significant differences in the signal intensity on T2-weighted images and in the presence or absence of CBD and MPD strictures, calcifications, and cystic lesions between groove pancreatic carcinomas and groove pancreatitis. However, patchy focal enhancement in the portal venous phase was more commonly observed in groove pancreatitis than groove pancreatic carcinoma (Reviewers 1 and 2: 14/15 [93.3%] vs. 1/7 [14.3%], P<0.0001). In addition, peripheral enhancement was only seen in groove pancreatic carcinomas (Reviewer 1: 4/7 [57.1%] vs. 0/15 [0%], P<0.005, and Reviewer 2: 3/7 [42.9%] vs. 0/15 [0%], P<0.05). CONCLUSION: The portal venous phase may be helpful for the differential diagnosis of groove pancreatic carcinomas and groove pancreatitis.

4 Article MRI findings of pancreatic lymphoma and autoimmune pancreatitis: a comparative study. 2010

Ishigami, Kousei / Tajima, Tsuyoshi / Nishie, Akihiro / Ushijima, Yasuhiro / Fujita, Nobuhiro / Asayama, Yoshiki / Kakihara, Daisuke / Irie, Hiroyuki / Ito, Tetsuhide / Igarashi, Hisato / Nakamura, Masafumi / Honda, Hiroshi. ·Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Ishigamikousei@aol.com ·Eur J Radiol · Pubmed #19375258.

ABSTRACT: PURPOSE: To clarify whether there are differences in MRI findings between pancreatic lymphomas and autoimmune pancreatitis (AIP). MATERIALS AND METHODS: MRI of 8 patients with pancreatic lymphomas and 21 patients with AIP were retrospectively reviewed. For multifocal pancreatic lymphomas (n=2) and AIP (n=4), the largest 2 lesions were evaluated. Ten pancreatic lymphomas and 25 AIP were compared on three bases: the signal intensity on T2-weighted images, internal homogeneity, and presence or absence of capsule-like rim. In 8 lymphomas and 19 AIP, the enhancement pattern on dynamic MRI was compared, as well. RESULTS: On T2-weighted images, pancreatic lymphomas comprised 5, 5 and 4 lesions with low (iso), slightly high, and moderately high intensity, respectively, while the numbers for AIP were 14, 10, and 1 (P<0.01). Nine of 10 (90%) lymphomas appeared homogenous, and 11 of 25 (44%) AIP were homogenous (P<0.05). A capsule-like rim was present in 9 of 25 (36%) AIP, but was not seen in lymphomas (P<0.05). On dynamic MRI, 18 of 19 (94.7%) AIP showed persistent (n=5) or delayed enhancement (n=13), and 6 of 8 (75%) lymphomas showed low intensity without delayed enhancement (P<0.001). CONCLUSION: MRI findings for pancreatic lymphomas and AIP were significantly different, which may be helpful for the differential diagnosis of these two diseases.

5 Article Significance of perivascular soft tissue around the common hepatic and proximal superior mesenteric arteries arising after pancreaticoduodenectomy: evaluation with serial MDCT studies. 2008

Ishigami, Kousei / Yoshimitsu, Kengo / Irie, Hiroyuki / Tajima, Tsuyoshi / Asayama, Yoshiki / Hirakawa, Masakazu / Kakihara, Daisuke / Shioyama, Yoshiyuki / Nishihara, Yunosuke / Yamaguchi, Koji / Honda, Hiroshi. ·Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Ishigamikousei@aol.com ·Abdom Imaging · Pubmed #18219520.

ABSTRACT: PURPOSE: To evaluate the interval change of perivascular soft tissue (PVST) around the common hepatic and proximal superior mesenteric arteries arising after pancreaticoduodenectomy (PD) and to compare the difference between post operative change (benign PVST) and recurrence (malignant PVST). MATERIALS AND METHODS: Serial multidetector CT (MDCT) studies in 44 patients who underwent PD for periampullary carcinomas were retrospectively reviewed (Group A). The incidence and interval change of PVST were evaluated and compared to control group (Group B, 21 patients with PD for benign diseases). RESULTS: PVST was seen in all the 44 patients in Group A, and it was noted in 12 of 21 (57.1%) patients in Group B. Thirteen of 44 (29.5%) patients showed interval enlargement of PVST (malignant PVST), and 12 of 13 developed within 2 years after PD. There was higher incidence of malignant PVST in patients with lymph node metastasis (p < 0.01) and those with pancreas head carcinoma (p < 0.05). CONCLUSION: PVST is common after PD regardless of whether patients had malignant or benign diseases. PVST should be monitored for at least 2 years to distinguish recurrence from post operative change. Patients with lymph node metastasis and pancreas head carcinoma had a higher incidence of malignant PVST.