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Pancreatic Neoplasms: HELP
Articles by H. W. Sun
Based on 1 article published since 2010
(Why 1 article?)
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Between 2010 and 2020, H. W. Sun wrote the following article about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Mitochondrial tRNALeu(CUN) A12307G variant may not be associated pancreatic cancer. 2016

Li, Y / Huang, A W / Chen, Y Z / Yang, W J / Zhou, M T / Sun, H W. ·Department of Operating Room, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. · Department of Surgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. ·Genet Mol Res · Pubmed #27323166.

ABSTRACT: Mitochondrial DNA mutations that lead to mitochondrial dysfunction have long been proposed to play important roles in the development of pancreatic cancer. Of these, alterations to mitochondrial tRNA genes constitute the largest group. Most recently, a variation at position 12307 in the gene encoding tRNA(Leu(CUN)) has been reported to be associated with this disease. However, the molecular mechanism underlying this relationship remains poorly understood. To assess this association, we evaluated this variant by evolutionary conservation analysis, measurements of allelic frequencies among control subjects, and use of several bioinformatic tools to estimate potential structural and functional alterations. We found this residue to have a high conservation index; however, the presence of the A12307G variation in control subjects revealed by a literature search suggested it to be common in human populations. Moreover, RNAfold results showed that this variant did not alter the secondary structure of tRNA(Leu(CUN)). Through the application of a pathogenicity scoring system, this variant was determined to be a "neutral polymorphism," with a score of only 4 points based on current data. Thus, the contribution of the A12307G variant to pancreatic cancer needs to be addressed in further experimental studies.