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Pancreatic Neoplasms: HELP
Articles by Kazunori Shibao
Based on 2 articles published since 2009
(Why 2 articles?)
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Between 2009 and 2019, Kazunori Shibao wrote the following 2 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Mitochondrial transcription factor a worsens the clinical course of patients with pancreatic cancer through inhibition of apoptosis of cancer cells. 2014

Yamauchi, Masumi / Nakayama, Yoshifumi / Minagawa, Noritaka / Torigoe, Takayuki / Shibao, Kazunori / Yamaguchi, Koji. ·From the *Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Yahata-nishi-ku; and ‚ĆDepartment of Gastroenterological and General Surgery, Wakamatsu Hospital of University of Occupational and Environmental Health, Wakamatsu-ku, Kitakyushu, Japan. ·Pancreas · Pubmed #24622070.

ABSTRACT: OBJECTIVE: Mitochondrial transcription factor A (mtTFA) is mandatory for both the transcription and maintenance of mitochondrial DNA. This study aimed to investigate the significance of mtTFA expression in pancreatic ductal adenocarcinoma (PDAC). METHODS: Surgical specimens from 93 patients with PDAC who all underwent pancreatectomy were immunohistochemically stained using a polyclonal anti-mtTFA antibody. The relationship between the expression of mtTFA, clinicopathologic factors, and prognosis of these patients were evaluated. RESULTS: Positive mtTFA expression was significantly associated with lymphovascular invasion and metastatic recurrence in the liver and correlated with an advanced surgical stage. A univariate analysis showed that the patients with positive mtTFA expression had a significantly shorter survival time than those patients with negative mtTFA expression, and a multivariate analysis revealed that mtTFA expression was one of the independent prognostic factors in patients with PDAC. Positive mtTFA expression was significantly correlated with a low apoptotic index but not significantly correlated with the mind bomb homolog-1 (MIB-1) index. CONCLUSIONS: The expression mtTFA worsens the clinical course of patients with PDAC through the inhibition of apoptosis of PDAC cells and is an independent marker for the poor prognosis of the patients with PDAC after pancreatectomy. Mitochondrial transcription factor A may be a novel target for the treatment of PDAC.

2 Article Pancreatic somatostatinoma diagnosed preoperatively: report of a case. 2014

Mori, Yasuhisa / Sato, Norihiro / Taniguchi, Ryuta / Tamura, Toshihisa / Minagawa, Noritaka / Shibao, Kazunori / Higure, Aiichiro / Nakamoto, Mitsuhiro / Taguchi, Masashi / Yamaguchi, Koji. ·Department of Surgery, School of Medicine, University of Occupational and Environmental Health. Kitakyushu, Japan. y-mori@med.uoeh-u.ac.jp. ·JOP · Pubmed #24413789.

ABSTRACT: CONTEXT: Somatostatinoma is a rare neoplasm of the pancreas. Preoperative diagnosis is often difficult. CASE REPORT: We report a 72-year-old woman with a pancreatic head tumor measuring 37 mm in diameter, and enlargement of the lymph nodes on the anterior surface of the pancreatic head and the posterior surface of the horizontal part of the duodenum. Laboratory data showed an elevated plasma somatostatin concentration. Examination of a biopsy specimen of the pancreatic head mass obtained by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) showed histopathological features of a neuroendocrine tumor. Immunohistochemical staining showed that the tumor cells were positive for somatostatin, leading to a preoperative diagnosis of pancreatic somatostatinoma. The patient underwent pylorus-preserving pancreaticoduodenectomy. The plasma somatostatin concentration decreased progressively after surgery. CONCLUSIONS: A rare case of pancreatic somatostatinoma with lymph node metastases was presented. Immunohistochemical analysis of a biopsy specimen obtained by EUS-FNA was useful for preoperative diagnosis.