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Pancreatic Neoplasms: HELP
Articles by D. Saha
Based on 1 article published since 2010
(Why 1 article?)
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Between 2010 and 2020, D. Saha wrote the following article about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Review Pancreatic stellate cells in pancreatic cancer: In focus. 2017

Allam, A / Thomsen, A R / Gothwal, M / Saha, D / Maurer, J / Brunner, T B. ·Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany; Clinical Oncology and Nuclear Medicine Department, Assiut University Hospitals, Egypt. · Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK), Partner Site Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. · Department of Visceral Surgery, Medical Center, Faculty of Medicine, University of Freiburg, Germany. · Department of Visceral Surgery, Medical Center, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK), Partner Site Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. · Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK), Partner Site Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: thomas.brunner@uniklinik-freiburg.de. ·Pancreatology · Pubmed #28601475.

ABSTRACT: Pancreatic stellate cells are stromal cells that have multiple physiological functions such as the production of extracellular matrix, stimulation of amylase secretion, phagocytosis and immunity. In pancreatic cancer, stellate cells exhibit a different myofibroblastic-like morphology with the expression of alpha-smooth muscle actin, the activated form is engaged in several mechanisms that support tumorigenesis and cancer invasion and progression. In contrast to the aforementioned observations, eliminating the stromal cells that are positive for alpha-smooth muscle actin resulted in immune-evasion of the cancer cells and resulted in worse prognosis in animal models. Understanding the cancer-stromal signaling in pancreatic adenocarcinoma will provide novel strategies for therapy. Here we provide an updated review of studies that handle the topic "pancreatic stellate cells in cancer" and recent experimental approaches that can be the base for future directions in therapy.