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Pancreatic Neoplasms: HELP
Articles by Stefania Saccomanno
Based on 1 article published since 2008
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Between 2008 and 2019, Stefania Saccomanno wrote the following article about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article PDX-1 mRNA expression in endoscopic ultrasound-guided fine needle cytoaspirate: perspectives in the diagnosis of pancreatic cancer. 2015

Marzioni, Marco / Germani, Ugo / Agostinelli, Laura / Bedogni, Giorgio / Saccomanno, Stefania / Marini, Francesco / Bellentani, Stefano / Barbera, Carmelo / De Minicis, Samuele / Rychlicki, Chiara / Santinelli, Alfredo / Ferretti, Maurizio / Di Maira, Pier Vittorio / Baroni, Gianluca Svegliati / Benedetti, Antonio / Caletti, Giancarlo / Lorenzini, Ivano / Fusaroli, Pietro. ·Clinic of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy. Electronic address: m.marzioni@univpm.it. · Division of Gastroenterology, Azienda Ospedaliero Universitaria "Ospedali Riuniti", Ancona, Italy. · Clinic of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy. · Epidemiology Unit, Centro Studi Fegato, Trieste, Italy. · Servizio di Gastroenterologia - Ospedale "Ramazzini" Carpi, Modena, Italy. · Institute of Pathologic Anatomy, Università Politecnica delle Marche, Ancona, Italy. · Division of Cytopathology, Azienda Ospedaliero Universitaria "Ospedali Riuniti", Ancona, Italy. · Division of Gastroenterology and Digestive Endoscopy, Università degli Studi di Bologna, Castel San Pietro Terme Hospital, Castel San Pietro Terme, Italy. ·Dig Liver Dis · Pubmed #25454709.

ABSTRACT: BACKGROUND AND AIMS: Endoscopic ultrasound-guided fine needle aspiration is routinely used in the diagnostic work up of pancreatic cancer but has a low sensitivity. Studies showed that Pancreatic Duodenal Homeobox-1 (PDX-1) is expressed in pancreatic cancer, which is associated with a worse prognosis. We aimed to verify whether the assessment of PDX-1 in endoscopic ultrasound-guided fine needle aspiration samples may be helpful for the diagnosis of pancreatic cancer. METHODS: mRNA of 54 pancreatic cancer and 25 cystic lesions was extracted. PDX-1 expression was assessed by Real-Time PCR. RESULTS: In all but two patients with pancreatic cancer, PDX-1 was expressed and was found positive in 7 patients with pancreatic cancer in which cytology was negative. The positivity was associated with a probability of 0.98 (95% CI 0.90-1.00) of having cancer and the negativity with one of 0.08 (95% CI 0.01-0.27). The probability of cancer rose to 1.00 (95% CI 0.97-1.00) for patients positive to both PDX-1 and cytology and fell to 0.0 (95% CI 0.00-0.15) in patients negative for both. CONCLUSIONS: PDX-1mRNA is detectable in samples of pancreatic cancer. Its quantification may be helpful to improve the diagnosis of pancreatic cancer.