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Pancreatic Neoplasms: HELP
Articles by Luis Sabater
Based on 11 articles published since 2008
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Between 2008 and 2019, Luis Sabater wrote the following 11 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Guideline [Recommendations for the diagnosis, staging and treatment of pre-malignant lesions and pancreatic adenocarcinoma]. 2016

Martin-Richard, Marta / Ginès, Angels / Ayuso, Juan Ramón / Sabater, Luis / Fabregat, Joan / Mendez, Ramiro / Fernández-Esparrach, Glòria / Molero, Xavier / Vaquero, Eva C / Cuatrecasas, Miriam / Ferrández, Antonio / Maurel, Joan / Anonymous3560884. ·Servicio de Oncología Médica, Hospital Sant Pau, Barcelona, España. Electronic address: mmartinri@santpau.cat. · Servicio de Gastroenterología, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Barcelona, España. · Servicio de Radiología, Hospital Clínic de Barcelona, Barcelona, España. · Servicio de Cirugía, Hospital Clínico Universitario de Valencia, Valencia, España. · Servicio de Cirugía, Hospital de Bellvitge, Barcelona, España. · Servicio de Radiología, Hospital Clínico San Carlos, Madrid, España. · Servicio de Gastroenterología, Hospital Vall d'Hebron, Barcelona, España. · Servicio de Anatomía Patológica, Hospital Clínic de Barcelona, Barcelona, España. · Servicio de Anatomía Patológica, Hospital Clínico Universitario de Valencia, Valencia, España. · Servicio de Oncología Médica, Translational Genomics and Targeted Therapeutics in Solid Tumors Group, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, España; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Barcelona, España. ·Med Clin (Barc) · Pubmed #27726847.

ABSTRACT: BACKGROUND AND OBJECTIVE: Clinical management of adenocarcinoma of the pancreas is complex, and requires a multidisciplinary approach. The same applies for the premalignant lesions that are increasingly being diagnosed. The current document is an update on the diagnosis and management of premalignant lesions and adenocarcinoma of the pancreas. PATIENTS AND METHODS: A conference to establish the basis of the literature review and manuscript redaction was organized by the Grupo Español Multidisciplinar en Cáncer Digestivo. Experts in the field from different specialties (Gastroenterology, Surgery, Radiology, Pathology, Medical Oncology and Radiation Oncology) met to prepare the present document. RESULTS: The current literature was reviewed and discussed, with subsequent deliberation on the evidence. CONCLUSIONS: Final recommendations were established in view of all the above.

2 Guideline [Recommendations for diagnosis, staging and treatment of pancreatic cancer (Part II)]. 2010

Navarro, Salvador / Vaquero, Eva / Maurel, Joan / Bombí, Josep Antoni / De Juan, Carmen / Feliu, Jaime / Fernández Cruz, Laureano / Ginés, Angels / Girela, Enrique / Rodríguez, Ricardo / Sabater, Luis / Anonymous1440657 / Anonymous1450657 / Anonymous1460657 / Anonymous1470657 / Anonymous1480657 / Anonymous1490657. ·Servicio de Gastroenterología, CIBERehd, IDIBAPS, Hospital Clínic, Universitat de Barcelona, Barcelona, España. snavarro@clinic.ub.es ·Med Clin (Barc) · Pubmed #20356609.

ABSTRACT: -- No abstract --

3 Guideline [Recommendations for diagnosis, staging and treatment of pancreatic cancer (Part I). Grupo Español de Consenso en Cáncer de Páncreas]. 2010

Navarro, Salvador / Vaquero, Eva / Maurel, Joan / Bombí, Josep Antoni / De Juan, Carmen / Feliu, Jaime / Fernández Cruz, Laureano / Ginés, Angels / Girela, Enrique / Rodríguez, Ricardo / Sabater, Luis / Anonymous44180656 / Anonymous44190656 / Anonymous44200656 / Anonymous44210656 / Anonymous44220656 / Anonymous44230656. ·Servicio de Gastroenterología, CIBERehd, IDIBAPS, Hospital Clínic, Universitat de Barcelona, Barcelona, España. snavarro@clinic.ub.es ·Med Clin (Barc) · Pubmed #20346471.

ABSTRACT: -- No abstract --

4 Review Borderline resectable pancreatic cancer. Challenges and controversies. 2018

Sabater, Luis / Muñoz, Elena / Roselló, Susana / Dorcaratto, Dimitri / Garcés-Albir, Marina / Huerta, Marisol / Roda, Desamparados / Gómez-Mateo, María Carmen / Ferrández-Izquierdo, Antonio / Darder, Antonio / Cervantes, Andrés. ·Department of Surgery, Liver-Biliary and Pancreatic Unit, Biomedical Research Institute INCLIVA, Hospital Clinico University of Valencia, Spain. · CIBERONC Department of Medical Oncology, Biomedical Research Institute INCLIVA, University of Valencia, Spain. · Department of Pathology, Hospital Universitario Donostia, Spain. · Department of Pathology, Biomedical Research Institute INCLIVA, University of Valencia, Spain. · CIBERONC Department of Medical Oncology, Biomedical Research Institute INCLIVA, University of Valencia, Spain. Electronic address: andres.cervantes@uv.es. ·Cancer Treat Rev · Pubmed #29957372.

ABSTRACT: Pancreatic cancer is a dismal disease with an increasing incidence. Despite the majority of patients are not candidates for curative surgery, a subgroup of patients classified as borderline resectable pancreatic cancer can be selected in whom a sequential strategy of neoadjuvant therapy followed by surgery can provide better outcomes. Multidisciplinary approach and surgical pancreatic expertise are essential for successfully treating these patients. However, the lack of consensual definitions and therapies make the results of studies very difficult to interpret and hard to be implemented in some settings. In this article, we review the challenges of borderline resectable pancreatic cancer, the complexity of its management and controversies and point out where further research and international cooperation for a consensus strategy is urgently needed.

5 Review Is Percutaneous Transhepatic Biliary Drainage Better than Endoscopic Drainage in the Management of Jaundiced Patients Awaiting Pancreaticoduodenectomy? A Systematic Review and Meta-analysis. 2018

Dorcaratto, Dimitri / Hogan, Niamh M / Muñoz, Elena / Garcés, Marina / Limongelli, Paolo / Sabater, Luis / Ortega, Joaquin. ·Hepatobiliary and Pancreatic Unit, General and Digestive Surgery Department, Hospital Clõnico Universitario de Valencia, Valencia, Spain. Electronic address: dorcaratto.dimitri@gmail.com. · Royal College of Surgeons in Ireland, Dublin, Ireland. · Hepatobiliary and Pancreatic Unit, General and Digestive Surgery Department, Hospital Clõnico Universitario de Valencia, Valencia, Spain. · Department of Medical, Surgical, Neurologic, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy. ·J Vasc Interv Radiol · Pubmed #29548873.

ABSTRACT: PURPOSE: To compare postoperative complications in patients who underwent pancreatoduodenectomy after either endoscopic or percutaneous biliary drain (BD). MATERIAL AND METHODS: Data from studies comparing the rate of postoperative complications in patients who underwent endoscopic BD or percutaneous BD before pancreatoduodenectomy were extracted independently by 2 investigators. The primary outcome compared in the meta-analysis was the risk of postoperative complications. Secondary outcomes were the risks of procedure-related complications, postoperative mortality, postoperative pancreatic fistula, severe complications, and wound infection. For dichotomous variables, the odds ratio (OR) with 95% confidence interval (CI) was calculated. RESULTS: Thirteen studies, including 2334 patients (501 in the percutaneous BD group and 1833 in the endoscopic group), met the inclusion criteria. Postoperative and procedure-related complication rates were significantly lower in the percutaneous BD group (OR = .7, 95% CI = .52-.94, P = .02 and OR = .44, 95% CI = .23-.84, P = .01, respectively). No significant differences were observed when severe postoperative complications, postoperative mortality, postoperative pancreatic fistula, and wound infection rates were compared. CONCLUSIONS: In patients awaiting pancreatoduodenectomy, preoperative percutaneous BD is associated with fewer procedure-related or postoperative complications than endoscopic drain.

6 Review Outcome quality standards in pancreatic oncologic surgery. 2014

Sabater, Luis / García-Granero, Alvaro / Escrig-Sos, Javier / Gómez-Mateo, Maria Del Carmen / Sastre, Juan / Ferrández, Antonio / Ortega, Joaquín. ·Department of Surgery, Hospital Clínico, University of Valencia, Valencia, Spain, luis.sabater@uv.es. ·Ann Surg Oncol · Pubmed #24390708.

ABSTRACT: PURPOSE: To identify quality indicators and establish acceptable quality limits (AQLs) in pancreatic oncologic surgery using a formal statistical methodology. METHODS: Indicators have been identified through systematic literature reviews and guidelines for pancreatic surgery. AQLs were determined for each indicator with confidence intervals of 99.8 and 95 % above and below the weighted average by sample size from the different series examined. RESULTS: Several indicators have been identified with the following results as AQLs: resectability rate >59 %; morbidity, mortality, and pancreatic fistula rate in pancreaticoduodenectomy <55, <5, and <16 %, respectively; morbidity, mortality, and fistula rate in distal pancreatectomy <53, <4, and <31 %, respectively; number of lymph nodes retrieved >15; R1 resection <46 %; survival at 1, 3, and 5 years >54, >19, and >8 %, respectively. CONCLUSIONS: A series of different indicators for quality surgical care outcome in pancreatic cancer, as well as their limits, have been determined according to a standard methodology.

7 Article Outcome quality standards in pancreatic oncologic surgery in Spain. 2018

Sabater, Luis / Mora, Isabel / Gámez Del Castillo, Juan Manuel / Escrig-Sos, Javier / Muñoz-Forner, Elena / Garcés-Albir, Marina / Dorcaratto, Dimitri / Ortega, Joaquín. ·Servicio de Cirugía General, Hospital Clínico Universitario de Valencia, Valencia, España; Departamento de Cirugía, Universitat de València, Valencia, España. Electronic address: luis.sabater@uv.es. · Servicio de Cirugía General, Hospital Clínico Universitario de Valencia, Valencia, España. · Hospital General Universitario de Castellón, Castellón, España. · Servicio de Cirugía General, Hospital Clínico Universitario de Valencia, Valencia, España; Departamento de Cirugía, Universitat de València, Valencia, España. ·Cir Esp · Pubmed #29784432.

ABSTRACT: INTRODUCTION: To establish quality standards in oncologic surgery is a complex but necessary challenge to improve surgical outcomes. Unlike other tumors, there are no well-defined quality standards in pancreatic cancer. The aim of this study is to identify quality indicators in pancreatic oncologic surgery in Spain as well as their acceptable limits of variability. METHODS: Quality indicators were selected based on clinical practice guidelines, consensus conferences, reviews and national publications on oncologic pancreatic surgery between the years 2000 and 2016. Variability margins for each indicator have been determined by statistical process control techniques and graphically represented with the 99.8 and 95% confidence intervals above and below the weighted average according to sample size. RESULTS: The following indicators have been determined with their weighted average and acceptable quality limits: resectability rate 71% (>58%), morbidity 58% (<73%), mortality 4% (<10%), biliary leak 6% (<14%), pancreatic fistula rate 18% (<29%), hemorrhage 11% (<21%), reoperation rate 11% (<20%) and mean hospital stay (<21 days). CONCLUSIONS: To date, few related series have been published, and they present important methodological limitations. Among the selected indicators, the morbidity and mortality quality limits have come out higher than those obtained in international standards. It is necessary for Spanish pancreatic surgeons to adopt homogeneous criteria regarding indicators and their definitions to allow for the comparison of their results.

8 Article [Pseudoaneurysm of the superior mesenteric artery after pancreatoduodenectomy]. 2016

Ferro, Oscar / Soria, Jetzabel / Garcés, Marina / Guijarro, Jorge / Gámez, Juan Manuel / Sabater, Luis. ·Servicio de Cirugía General y Aparato Digestivo, Departamento de Cirugía, Hospital Clínico Universitario, Valencia, España. · Servicio de Radiología Intervencionista, Hospital Clínico Universitario, Valencia, España. · Servicio de Cirugía General y Aparato Digestivo, Departamento de Cirugía, Hospital Clínico Universitario, Valencia, España. Electronic address: luis.sabater@uv.es. ·Gastroenterol Hepatol · Pubmed #26096289.

ABSTRACT: -- No abstract --

9 Article Prognostic implications of the standardized study of resection margins in pancreatic cancers. 2014

Sabater, Luis / Gómez-Mateo, María del Carmen / López-Sebastián, Javier / Muñoz-Forner, Elena / Morera-Ocón, Francisco / Cervantes, Andrés / Roselló, Susana / Camps-Vilata, Bruno / Ferrández, Antonio / Ortega, Joaquín. ·Servicio de Cirugía General, Instituto de Investigación Sanitaria INCLIVA, Departamento de Cirugía, Universitat de València, Valencia, España. Electronic address: luis.sabater@uv.es. · Servicio de Anatomía Patológica, Instituto de Investigación Sanitaria INCLIVA, Departamento de Patología, Universitat de València, Valencia, España. · Servicio de Cirugía General, Hospital San Pablo Coquimbo, Coquimbo, Chile. · Servicio de Cirugía General, Instituto de Investigación Sanitaria INCLIVA, Departamento de Cirugía, Universitat de València, Valencia, España. · Servicio de Hematología y Oncología Médica, Instituto de Investigación Sanitaria INCLIVA, Universitat de València, Valencia, España. ·Cir Esp · Pubmed #24878428.

ABSTRACT: INTRODUCTION: Involvement of surgical resection margins is a fundamental prognostic factor in pancreatic oncological surgery. However, there is a lack of standardized histopathology definition. The aims of this study are to investigate the real rate of R1 resections when surgical specimens are evaluated according to a standardized protocol and to study its survival implications. PATIENTS Y METHODS: One hundred consecutive surgically resected patients with pancreatic ductal adenocarcinoma were included in the study. They were further divided in 2 groups: pre-protocol, evaluated before the introduction of the standardized protocol and post-protocol, analyzed with the standardized protocol. RESULTS: R0 resection rate in the pre-protocol group was 78%, falling to 47% after the introduction of the standardized protocol (p=0,003). The posterior retroperitoneal margin was the most frequently involved margin. In cases with tumors located at the pancreatic head and analyzed according to the standardized protocol R1 involvement negatively affected survival. Median survival in the R0 group was 22 months versus 16 in those with the margin involved (HR: 2.044; IC 95% 1,00-4,16; P=.043). CONCLUSIONS: Standardized evaluation of the retroperitoneal margins in pancreatic cancer increases the rate of R1 patients. In cases with pancreatic cancer located at the pancreatic head involvement of posterior retroperitoneal margin significantly decreases survival.

10 Article High microvessel density in pancreatic ductal adenocarcinoma is associated with high grade. 2013

Barău, Anca / Ruiz-Sauri, Amparo / Valencia, Gerardo / Gómez-Mateo, Maria Del Carmen / Sabater, Luis / Ferrandez, Antonio / Llombart-Bosch, Antonio. ·Department of Internal Medicine, Emergency County Hospital Craiova, University of Medicine and Pharmacy Craiova, Petru Rareş 2, Craiova, 200349, Romania. anca_barau@yahoo.com ·Virchows Arch · Pubmed #23579431.

ABSTRACT: The objectives of this work are to study angiogenesis in pancreatic ductal adenocarcinoma using computerized morphometric and image analysis and to compare the microvascular density in intratumoral and peritumoral areas and normal pancreatic tissue. Microvascular density was analyzed in 60 cases of pancreatic ductal adenocarcinoma and 30 samples of normal pancreatic tissue using an avidin-biotin immunoperoxidase technique with an anti-CD31 antibody. Microvascular density (MVD) was analyzed through digital microimaging and computerized analysis. The blood vessel density in the tumor was significantly higher than in peritumoral areas and in normal pancreatic tissue. Well differentiated pancreatic ductal adenocarcinomas contained higher MVD than poorly differentiated carcinomas. In pancreatic adenocarcinoma, MVD is higher than in peritumoral tissue or normal pancreatic tissue.

11 Article [Pancreatic and periampullary tumors: morbidity, mortality, functional results and long-term survival]. 2009

Sabater, Luis / Calvete, Julio / Aparisi, Luis / Cánovas, Raul / Muñoz, Elena / Añón, Ramón / Roselló, Susana / Rodríguez, Edith / Camps, Bruno / Alfonso, Raquel / Sala, Carlos / Sastre, Juan / Cervantes, Andrés / Lledó, Salvador. ·Unidad de Cirugía Hepatobiliopancreática, Servicio de Cirugía General y Aparato Digestivo, Hospital Clínico Universitario de Valencia, Valencia, España. luis_sabater@hotmail.com ·Cir Esp · Pubmed #19616203.

ABSTRACT: AIMS: To evaluate postoperative morbidity and mortality, pancreatic function and long-term survival in patients with surgically treated pancreatic or periampullar tumours. PATIENTS AND METHODS: Cohort study including 160 patients consecutively operated on: 80 pancreaticoduodenectomies (PD), 30 distal pancreatectomies (DP), 7 total pancreatectomies, 4 central pancreatic resections and 3 ampullectomies. The tumour was not resected in 36 patients. Pancreatic function was evaluated by oral glucose tolerance test, faecal fat excretion and elastase. RESULTS: Resectability rate was 77.5%. In resected patients (n = 124), 38.7% had complications with a pancreatic fistula rate of 6.4% and a mortality rate of 4%. In PD, endocrine function worsened in 41% and 58.6% had steatorrhoea; these figures in DP were 53.6% and 21.7% respectively. In the 36 non-resected patients, postoperative morbidity was 27.7% and mortality 8.3%. Two and five-year survival rates in resected patients with pancreatic cancer were 42% and 9% respectively; in malignant ampulloma 71% and 53%; in mucinous adenocarcinomas 83% and 33%; in duodenal adenocarcinoma 100% and 75%; and in distal cholangiocarcinoma 50% and 50%. CONCLUSIONS: Morbidity associated with resective pancreatic surgery is still high, but perioperative mortality is low. Endocrine and exocrine disturbances are very common depending on the type of resection. Despite the associated morbidity and functional disorders, surgery provides long-term survival in selected cases.