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Pancreatic Neoplasms: HELP
Articles by Vittoria Rufini
Based on 12 articles published since 2008
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Between 2008 and 2019, V. Rufini wrote the following 12 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Review Clinical applications of (18)F-FDG PET in the management of hepatobiliary and pancreatic tumors. 2012

De Gaetano, Anna Maria / Rufini, Vittoria / Castaldi, Paola / Gatto, Anna Maria / Filograna, Laura / Giordano, Alessandro / Bonomo, Lorenzo. ·Department of Bioimaging and Radiological Sciences, Institute of Radiology, Agostino Gemelli Hospital, Catholic University of the Sacred Heart, Rome, Italy. adegaetano@rm.unicatt.it ·Abdom Imaging · Pubmed #22527152.

ABSTRACT: The assessment of hepatobiliary and pancreatic tumors is commonly achieved by ultrasound, computed tomography (CT), and magnetic resonance. The 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) detects increased glucose metabolism associated with neoplastic lesions, provides high accuracy in most cancer imaging applications and is now widely used in clinical practice. However, PET is not always useful and accurate knowledge of appropriate indications is essential for a proper clinical management. (18)F-FDG is transported into cells and phosphorylated by the enzyme hexokinase to (18)F-FDG-6-phosphate, which cannot proceed down the glycolytic pathway and therefore is accumulated in the malignant tissue. PET allows accurate quantification of FDG uptake in tissue, and previous studies have demonstrated that standardized uptake values provide highly reproducible parameters of tumor glucose use (Weber et al., J Nucl Med 40:1771-1777, 1999). The recent development and diffusion of hybrid PET-CT scanners allows functional and anatomic data to be obtained in a single examination, improving lesion localization and resulting in significant diagnostic improvement (Wahl, J Nucl Med 45:82S-95S, 2004). Moreover, CT can be performed diagnostically with the use of intravenous and oral contrast and simultaneous PET-contrast-enhanced CT scanning appears to be an efficient method in cancer evaluation. However, in most centers, a low-dose CT is routinely performed without contrast media infusion.Proper patient preparation, scanning protocol, combined assessment of PET and CT data, and the evaluation of conventional imaging findings are essential to define disease and to avoid diagnostic pitfalls. The role of PET and PET-CT in malignancies of the liver, biliary tract, and pancreas is here reviewed; normal patterns, representative cases, and common pitfalls are also presented.

2 Review Role of PET/CT in the functional imaging of endocrine pancreatic tumors. 2012

Rufini, Vittoria / Baum, Richard P / Castaldi, Paola / Treglia, Giorgio / De Gaetano, Anna Maria / Carreras, Cecilia / Kaemmerer, Daniel / Hommann, Merten / Hörsch, Dieter / Bonomo, Lorenzo / Giordano, Alessandro. ·Department of Bioimaging and Radiological Sciences, Institute of Nuclear Medicine, Agostino Gemelli Hospital, Università Cattolica del Sacro Cuore, Roma, Italy. v.rufini@rm.unicatt.it ·Abdom Imaging · Pubmed #22422069.

ABSTRACT: Endocrine pancreatic tumors (EPTs) are a heterogeneous group of neoplasms with variable clinical and biological features and prognosis, ranging from very slow-growing tumors to highly aggressive and very malignant ones. As other neuroendocrine tumors, EPTs are characterized by the presence of neuroamine uptake mechanisms and/or peptide receptors at the cell membrane and these features constitute the basis of the clinical use of specific radiolabeled ligands, both for imaging and therapy. The more widespread use of hybrid machines, i.e., positron emission tomography/computed tomography (PET/CT), allows to perform imaging with high resolution and high diagnostic accuracy especially for small lesions, and to correlate anatomic location with function. The recent WHO recommendations for classification and prognostic factors help the selection of tracers likely to show a positive image on PET; therefore, tracers exploiting specific metabolic patterns ((18)F-DOPA and (11)C-5-HTP) or specific receptor expression ((68)Ga-DOTA-peptides) are suited to well-differentiated tumors, while the use of (18)F-FDG is preferred for poorly-differentiated neoplasms with high proliferative activity and loss of neuroendocrine features. In differentiated EPTs, (11)C-5-HTP performs better than (18)F-DOPA even though its use is hampered by its complex production and limited availability and experience; (68)Ga-peptides are indicated for all type of gastroenteropancreatic (GEP) neuroendocrine tumors, regardless of their functional activity. In addition, (68)Ga-DOTA-peptides play a distinctive role in planning peptide receptor radionuclide therapy.

3 Review Diagnostic performance of Gallium-68 somatostatin receptor PET and PET/CT in patients with thoracic and gastroenteropancreatic neuroendocrine tumours: a meta-analysis. 2012

Treglia, Giorgio / Castaldi, Paola / Rindi, Guido / Giordano, Alessandro / Rufini, Vittoria. ·Institute of Nuclear Medicine, Catholic University of the Sacred Heart, Largo Gemelli, 8, 00168, Rome, Italy. giorgiomednuc@libero.it ·Endocrine · Pubmed #22350660.

ABSTRACT: RESULTS: Sixteen studies comprising 567 patients were included in this meta-analysis. The pooled sensitivity and specificity of SMSR PET or PET/CT in detecting NETs were 93% (95% confidence interval [95% CI]: 91-95%) and 91% (95% CI: 82-97%), respectively, on a per patient-based analysis. The area under the ROC curve was 0.96. In patients with suspicious thoracic and/or GEP NETs, SMSR PET and PET/CT demonstrated high sensitivity and specificity. These accurate techniques should be considered as first-line diagnostic imaging methods in patients with suspicious thoracic and/or GEP NETs.

4 Article Pancreatic neuroendocrine tumors in MEN1 disease: a mono-centric longitudinal and prognostic study. 2018

Chiloiro, S / Lanza, F / Bianchi, A / Schinzari, G / Brizi, M G / Giampietro, A / Rufini, V / Inzani, F / Giordano, A / Rindi, G / Pontecorvi, A / De Marinis, L. ·Department of Endocrinology, Catholic University of the Sacred Heart, Rome, Italy. · Department of Radiology, Catholic University of the Sacred Heart, Rome, Italy. · Department of Oncology, Catholic University of the Sacred Heart, Rome, Italy. · Department of Nuclear Medicine, Catholic University of the Sacred Heart, Rome, Italy. · Department of Anatomic Pathology, Catholic University of the Sacred Heart, Rome, Italy. · Department of Endocrinology, Catholic University of the Sacred Heart, Rome, Italy. laurademarinis@yahoo.it. ·Endocrine · Pubmed #28567607.

ABSTRACT: PURPOSE: Multiple endocrine neoplasia type 1 (MEN1) is an inherited endocrine neoplastic syndrome associated with a greater risk of endocrine tumor development like pancreatic neuroendocrine tumors (p-NET), with different clinical characteristics from sporadic ones. This paper aims to compare clinical, hystological and morphological aspects of p-NET in patients affected from MEN1 (MEN1+) and not-affected ones (MEN1-). METHODS: We performed a retrospective observational study. Data was collected between December 2010 and December 2015, including patients with a histological diagnosis of p-NET and radiological imaging. We compared clinical, histological, radiological, and prognostic aspects of MEN+ p-NET with MEN-1 p-NET. RESULTS: Of the 45 patients enrolled, 13 MEN1+ and 21 MEN1- cases were analyzed. Frequency of not secreting p-NETs and insulin secreting p-NETs, histopathological grades and Ki67 expression were superimposable between MEN1+ and MEN1- patients. MEN1+ pNETs are more often multicentric compared to MEN1- pNETs. Frequency of liver and nodes metastatic spread was higher in MEN1- p-NET compared to MEN1+ p-NET. Analyzing p-NET according to the disease outcome, we found that recovered and stable p-NETs in MEN1+ patients, compared to MEN1- cases, are diagnosed at lower age (p = 0.04/p = 0.002) and that are more frequently multifocal lesions (p = 0.009/p = 0.002). CONCLUSIONS: In our study pNETs in MEN1+ and pNETs in MEN1- don't significantly differ for prognosis but only for clinical features. p-NET stage disease and prognosis can be positively influenced by early diagnosis and screening in index patients' first-degree relatives.

5 Article The Accessory Spleen Is an Important Pitfall of 68Ga-DOTANOC PET/CT in the Workup for Pancreatic Neuroendocrine Neoplasm. 2017

Rufini, Vittoria / Inzani, Frediano / Stefanelli, Antonella / Castaldi, Paola / Perotti, Germano / Cinquino, Annarita / Indovina, Luca / Rindi, Guido. ·From the *Institute of Nuclear Medicine, †Roma ENETS Center of Excellence for the Diagnosis and Cure of Neuroendocrine Tumors, ‡Institute of Pathology, and §Division of Medical Physics, Università Cattolica del Sacro Cuore-Fondazione Policlinico A. Gemelli, Rome, Italy. ·Pancreas · Pubmed #27846139.

ABSTRACT: OBJECTIVE: The aim of the study was to assess the value and potential pitfalls of Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) in patients with suspected pancreatic neuroendocrine neoplasms (pNEN). METHODS: Consecutive patients referred for Ga-DOTANOC PET/CT for suspected pNEN between May 1, 2011, and October 31, 2014, were retrospectively assessed. Scan data were compared with cytological/histological final diagnosis. Pancreatic neuroendocrine neoplasm detection rate was determined on per-patient and per-lesion basis. Maximum standardized uptake values of lesions were determined. RESULTS: Fifty-eight patients with 65 lesions were enrolled. Twelve patients had nonconfirmed diagnosis; of these, 7 were positive and 5 negative at PET/CT. Of 46 patients with confirmed diagnosis, 36 had pNEN; of these, 33 were positive, 1 negative, and 2 nonevaluable at PET/CT. Ten patients had non-NE lesions, of which 8 were positive, 1 negative, and 1 nonevaluable at PET/CT. Of 48 patients with positive PET/CT, 8 proved to have non-NE lesions, of which 6 were intrapancreatic accessory spleen. No significant maximum standardized uptake values difference was found between pNEN and non-NE lesions. CONCLUSIONS: Intrapancreatic accessory spleen is an important pitfall in Ga-DOTANOC PET/CT for suspected pNEN. Cytological/histological confirmation is mandatory before any surgical procedure is undertaken.

6 Article Evaluation of the Added Value of Diffusion-Weighted Imaging to Conventional Magnetic Resonance Imaging in Pancreatic Neuroendocrine Tumors and Comparison With 68Ga-DOTANOC Positron Emission Tomography/Computed Tomography. 2016

Farchione, Alessandra / Rufini, Vittoria / Brizi, Maria Gabriella / Iacovazzo, Donato / Larghi, Alberto / Massara, Roberto Maria / Petrone, Gianluigi / Poscia, Andrea / Treglia, Giorgio / De Marinis, Laura / Giordano, Alessandro / Rindi, Guido / Bonomo, Lorenzo. ·From the Institutes of *Radiology and †Nuclear Medicine, Department of Radiological Sciences; ‡Division of Endocrinology; §Digestive Endoscopy Unit; ∥Institute of Pathology; and ¶Institute of Hygiene, Università Cattolica del Sacro Cuore, Rome, Italy; and #Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland. ·Pancreas · Pubmed #26418904.

ABSTRACT: OBJECTIVES: The aims of this study were to investigate the added value of diffusion-weighted imaging (DWI) in pancreatic neuroendocrine tumor (pNET) evaluation and to compare magnetic resonance imaging (MRI) to Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) results. METHODS: Morphological MRI (T2-weighted [T2-w] + contrast-enhanced [CE] T1-w) and DWI (T2-w + DWI) and Ga-DOTANOC PET/CT in 25 patients/30 pNETs were retrospectively evaluated. Per-patient and per-lesion detection rates (pDR and lDR, respectively) were calculated. Apparent diffusion coefficient values were compared among pNET and surrounding and normal pancreas (control group, 18 patients). Apparent diffusion coefficient and standardized uptake value (SUV) values were compared among different grading and staging groups. RESULTS: No statistically significant differences in PET/CT and MRI session detection rates were found (morphological MRI and DW-MRI, 88% pDR and 87% lDR; combined evaluation, 92% pDR and 90% lDR; Ga-DOTANOC PET/CT, 88% pDR and 80% lDR). Consensus reading (morphological/DW-MRI + PET/CT) improved pDR and lDR (100%). Apparent diffusion coefficient mean value was significantly lower compared with surrounding and normal parenchyma (P < 0.01). The apparent diffusion coefficient and SUV values of pNETs among different grading and staging groups were not statistically different. CONCLUSIONS: Conventional MRI, DW-MRI + T2-w sequences, and Ga-DOTANOC PET/CT can be alternative tools in pNET detection. Diffusion-weighted MRI could be valuable in patients with clinical suspicion but negative conventional imaging findings. However, the consensus reading of the 3 techniques seems the best approach.

7 Article Intrapancreatic accessory spleen detected by 68Ga DOTANOC PET/CT and 99mTc-colloid SPECT/CT scintigraphy. 2015

Collarino, Angela / del Ciello, Annemilia / Perotti, Germano / Rufini, Vittoria. ·From the *Institute of Nuclear Medicine, and †Institute of Radiology, Università Cattolica del Sacro Cuore, Rome, Italy. ·Clin Nucl Med · Pubmed #25275421.

ABSTRACT: A 77-year-old man was referred to our center for a suspected neuroendocrine neoplasm in the pancreatic tail, incidentally detected at CT. Ga DOTANOC PET/CT showed intense tracer uptake in the pancreatic lesion. At MRI, the lesion was similar to the spleen on all sequences, suggesting the presence of intrapancreatic accessory spleen. A Tc-colloid SPECT/CT scan performed to differentiate spleen tissue from neuroendocrine tumor revealed a focal uptake in the pancreatic lesion, thus confirming the presence of ectopic spleen and avoiding unnecessary surgery.

8 Article A rare case of ectopic adrenocorticotropic hormone syndrome caused by a metastatic neuroendocrine tumor of the pancreas detected by 68Ga-DOTANOC and 18F-FDG PET/CT. 2013

Treglia, Giorgio / Salomone, Enrica / Petrone, Gianluigi / Giaccari, Andrea / Rindi, Guido / Rufini, Vittoria. ·Institute of Nuclear Medicine, Department of Bioimaging and Radiological Sciences, Catholic University of the Sacred Heart, Rome, Italy. giorgiomednuc@libero.it ·Clin Nucl Med · Pubmed #23486330.

ABSTRACT: We report a rare case of ectopic adrenocorticotropic hormone (ACTH) syndrome caused by a metastatic neuroendocrine tumor (NET) of the pancreas detected by PET/CT using different tracers. A 43-year-old female patient with Cushing syndrome (CS) by suspected ectopic ACTH secretion underwent a 68Ga-DOTANOC and a 18F-FDG PET/CT. Both these functional imaging techniques revealed increased tracer uptake in a pancreatic mass and multiple liver metastases. Histology showed the presence of a mildly differentiated pancreatic NET. 68Ga-DOTANOC PET/CT may be a useful functional imaging method, complementary to 18F-FDG PET/CT, in detecting ACTH-secreting pancreatic NETs.

9 Article A case of insulinoma detected by (68)Ga-DOTANOC PET/CT and missed by (18)F-dihydroxyphenylalanine PET/CT. 2013

Treglia, Giorgio / Inzani, Frediano / Campanini, Nicoletta / Rindi, Guido / Agnes, Salvatore / Giordano, Alessandro / Rufini, Vittoria. ·Institute of Nuclear Medicine, Department of Bioimaging and Radiological Sciences, Catholic University of the Sacred Heart, Rome, Italy. giorgiomednuc@libero.it ·Clin Nucl Med · Pubmed #23377414.

ABSTRACT: A 65-year-old woman with suspected insulinoma on the basis of clinical, biochemical, and conventional imaging data underwent F-dihydroxyphenylalanine (DOPA) PET/CT and Ga-DOTANOC PET/CT. F-DOPA PET/CT did not show any focal uptake in the pancreas, whereas Ga-DOTANOC PET/CT showed a focal area of intense uptake in the pancreatic tail. The patient underwent surgery and an insulinoma of about 20 mm in diameter was detected in the pancreatic tail. F-DOPA PET may fail in localizing insulin secreting tumors in adults; in these cases, the use of Ga-somatostatin analogs may lead to the correct diagnosis.

10 Article Usefulness of 18F-FDG PET/CT in an unusual case of solid-pseudopapillary pancreatic tumor in childhood with aggressive behavior. 2013

Treglia, Giorgio / Caporale, Nicoletta / Rufini, Vittoria / Callea, Francesco / Locatelli, Franco / Giordano, Alessandro. ·Institute of Nuclear Medicine, Department of Bioimaging and Radiological Sciences, Catholic University of the Sacred Heart, and Department of Oncohematology, Pediatric Hospital Bambino Gesù, Rome, Italy. giorgiomednuc@libero.it ·Clin Nucl Med · Pubmed #23242062.

ABSTRACT: We report an unusual case of a solid-pseudopapillary pancreatic tumor (SPPT) with aggressive behavior that occurred in a 16-year-old male patient. ¹⁸F fluorodeoxyglucose PET/CT showed increased radiopharmaceutical uptake in a solid mass of the body of the pancreas, in several liver lesions, and in multiple peritoneal implants, corresponding to an SPPT with liver and peritoneal metastases, respectively. Based on PET/CT findings, the patient was referred to chemotherapy. In this unusual case of pediatric SPPT with aggressive behavior, ¹⁸F fluorodeoxyglucose PET/CT has been useful in staging the disease and in treatment planning.

11 Minor Is 18F-Fluorodeoxyglucose the Tracer of Choice for Functional Imaging of Neuroendocrine Tumors Grade 3? A Case Report. 2018

Lorusso, Margherita / Inzani, Frediano / Castaldi, Paola / Menghi, Roberta / Schinzari, Giovanni / Rindi, Guido / Rufini, Vittoria. ·Institute of Nuclear Medicine Università Cattolica del Sacro Cuore-Fondazione Policlinico A. Gemelli Rome ENETS Center of Excellence for the Diagnosis and Cure of Neuroendocrine Tumors Rome, Italy Institute of Pathology Università Cattolica del Sacro Cuore-Fondazione Policlinico A. Gemelli Rome ENETS Center of Excellence for the Diagnosis and Cure of Neuroendocrine Tumors Rome, Italy Nuclear Medicine, Department of Radiology and Clinical Radiotherapy Policlinico SS Annunziata Chieti, Italy Institute of Nuclear Medicine Università Cattolica del Sacro Cuore-Fondazione Policlinico A. Gemelli Rome ENETS Center of Excellence for the Diagnosis and Cure of Neuroendocrine Tumors Rome, Italy Department of Digestive Surgery Università Cattolica del Sacro Cuore-Fondazione Policlinico A. Gemelli Rome ENETS Center of Excellence for the Diagnosis and Cure of Neuroendocrine Tumors Rome, Italy Department of Medical Oncology Università Cattolica del Sacro Cuore-Fondazione Policlinico A. Gemelli Rome ENETS Center of Excellence for the Diagnosis and Cure of Neuroendocrine Tumors Rome, Italy Institute of Pathology Università Cattolica del Sacro Cuore-Fondazione Policlinico A. Gemelli Rome ENETS Center of Excellence for the Diagnosis and Cure of Neuroendocrine Tumors Rome, Italy Institute of Nuclear Medicine Università Cattolica del Sacro Cuore-Fondazione Policlinico A. Gemelli Rome ENETS Center of Excellence for the Diagnosis and Cure of Neuroendocrine Tumors Rome, Italy vittoria.rufini@unicatt.it. ·Pancreas · Pubmed #29521949.

ABSTRACT: -- No abstract --

12 Minor Masking effect of chronic pancreatitis in the interpretation of somatostatin receptor positron emission tomography in pancreatic neuroendocrine tumors. 2013

Treglia, Giorgio / Farchione, Alessandra / Stefanelli, Antonella / Brizi, Maria Gabriella / Larghi, Alberto / Inzani, Frediano / Rindi, Guido / Rufini, Vittoria. · ·Pancreas · Pubmed #23591437.

ABSTRACT: -- No abstract --