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Pancreatic Neoplasms: HELP
Articles by William R. Reisacher
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, William R. Reisacher wrote the following 2 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Serum immunoglobulin e and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. 2014

Olson, Sara H / Hsu, Meier / Wiemels, Joseph L / Bracci, Paige M / Zhou, Mi / Patoka, Joseph / Reisacher, William R / Wang, Julie / Kurtz, Robert C / Silverman, Debra T / Stolzenberg-Solomon, Rachael Z. ·Authors' Affiliations: Department of Epidemiology and Biostatistics; olsons@mskcc.org. · Authors' Affiliations: Department of Epidemiology and Biostatistics; · Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, San Francisco, California; · Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical College, New York, New York; · Division of Pediatric Allergy and Immunology, Mt. Sinai Medical Center; · Department of Medicine, Memorial Sloan Kettering Cancer Center; · Occupational and Environmental Epidemiology Branch; and. · Branch of Nutritional Epidemiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland. ·Cancer Epidemiol Biomarkers Prev · Pubmed #24718282.

ABSTRACT: Epidemiologic studies have consistently found that self-reported allergies are associated with reduced risk of pancreatic cancer. Our aim was to prospectively assess the relationship between serum immunoglobulin E (IgE), a marker of allergy, and risk. This nested case-control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) included subjects enrolled in 1994 to 2001 and followed through 2010. There were 283 cases of pancreatic cancer and 544 controls matched on age, gender, race, and calendar date of blood draw. Using the ImmunoCAP system, we measured total IgE (normal, borderline, elevated), IgE to respiratory allergens, and IgE to food allergens (negative or positive) in serum collected at baseline. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. We assessed interactions with age, gender, smoking, body mass index, and time between randomization and case diagnosis. Overall, there was no association between the IgE measures and risk. We found a statistically significant interaction by baseline age: in those aged ≥65 years, elevated risks were observed for borderline total IgE (OR, 1.43; 95% CI, 0.88-2.32) and elevated total IgE (OR, 1.98; 95% CI, 1.16-3.37) and positive IgE to food allergens (OR, 2.83; 95% CI, 1.29-6.20); among participants <65 years, ORs were <1. Other interactions were not statistically significant. The reduced risk of pancreatic cancer associated with self-reported allergies is not reflected in serum IgE.

2 Article Allergies, obesity, other risk factors and survival from pancreatic cancer. 2010

Olson, Sara H / Chou, Joanne F / Ludwig, Emmy / O'Reilly, Eileen / Allen, Peter J / Jarnagin, William R / Bayuga, Sharon / Simon, Jennifer / Gonen, Mithat / Reisacher, William R / Kurtz, Robert C. ·Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. olsons@mskcc.org ·Int J Cancer · Pubmed #20143395.

ABSTRACT: Survival from pancreatic adenocarcinoma remains extremely poor, approximately 5% at 5 years. Risk factors include smoking, high body mass index (BMI), family history of pancreatic cancer, and long-standing diabetes; in contrast, allergies are associated with reduced risk. Little is known about associations between these factors and survival. We analyzed overall survival in relation to risk factors for 475 incident cases who took part in a hospital based case-control study. Analyses were conducted separately for those who did (160) and did not (315) undergo tumor resection. Kaplan-Meier methods were used to describe survival according to smoking, BMI, family history, diabetes, and presence of allergies. Cox proportional hazards models were used to adjust for covariates. There was no association with survival based on smoking, family history, or history of diabetes in either group. Among patients with resection, those with allergies showed nonstatistically significant longer survival, a median of 33.1 months (95% CI: 19.0-52.5) vs. 21.8 months (95% CI: 18.0-33.1), p = 0.25. The adjusted hazard ratio (HR) was 0.72 (95% CI: 0.43-1.23), p = 0.23. Among patients without resection, those with self-reported allergies survived significantly longer than those without allergies: 13.3 months (95% CI: 10.6-16.9) compared to 10.4 months (95% CI: 8.8-11.0), p = 0.04, with an adjusted HR of 0.68 (95% CI: 0.49-0.95), p = 0.02. Obesity was nonsignificantly associated with poorer survival, particularly in the resected group (HR = 1.62, 95% CI: 0.76-3.44). The mechanisms underlying the association between history of allergies and improved survival are unknown. These novel results need to be confirmed in other studies.