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Pancreatic Neoplasms: HELP
Articles by Boris A. Radeleff
Based on 3 articles published since 2010
(Why 3 articles?)
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Between 2010 and 2020, Boris Radeleff wrote the following 3 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Unresectable isolated hepatic metastases from solid pseudopapillary neoplasm of the pancreas: a case report of chemosaturation with high-dose melphalan. 2014

Hofmann, Helene / von Haken, Rebecca / Werner, Jens / Kortes, Nikolas / Bergmann, Frank / Schemmer, Peter / Jäger, Dirk / Radeleff, Boris / Schulze-Bergkamen, Henning. ·National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany. Electronic address: Helene.Hofmann@med.uni-heidelberg.de. · Department of Anesthesiology, University Clinic of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. · Department of Surgery, University Clinic of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. · Department of Radiology, University Clinic of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. · Department of Pathology, University Clinic of Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany. · National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany. · National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany; Marienhospital Wesel, Medical Department II, Pastor-Janssen-Strasse 8-38, 46483 Wesel, Germany. ·Pancreatology · Pubmed #25280592.

ABSTRACT: BACKGROUND/OBJECTIVES: Solid pseudopapillary neoplasms of the pancreas (SPN) are rare tumors. For patients with unresectable liver metastases of SPN, no standard treatment has been defined so far. Here we report a case of a 40-year-old woman with SPN and metastases confirmed to the liver, and disease progression in the liver after primary tumor resection and chemotherapy with gemcitabine and cisplatin. METHODS: Chemosaturation with percutaneous hepatic perfusions is a minimally invasive, repeatable regional therapy which delivers chemotherapy directly to the liver while limiting systemic toxicity. As an individual treatment approach, the patient was treated with chemosaturation with percutaneous hepatic perfusions of melphalan. RESULTS: The procedure was performed twice within 8 weeks after which the liver metastases showed a marked reduction in size and vascularization (partial response). Grade 3 leukopenia after the second procedure was managed effectively with granulocyte colony-stimulating factor. No other toxicities were observed. Ten months after initiating treatment, the patient had a good performance status and remained stable. CONCLUSIONS: For SPN with unresectable liver metastases and progression despite systemic treatment, repeat chemosaturation with high-dose melphalan may also offer an effective regional treatment option.

2 Article Portal vein embolization using a Histoacryl/Lipiodol mixture before right liver resection. 2012

Bellemann, Nadine / Stampfl, Ulrike / Sommer, Christof M / Kauczor, Hans-Ulrich / Schemmer, Peter / Radeleff, Boris A. ·Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany. nadine.bellemann@web.de ·Dig Surg · Pubmed #22797287.

ABSTRACT: PURPOSE: The purpose of this retrospective study was to evaluate the efficacy and safety of percutaneous transhepatic portal vein embolization (PVE) of the right liver lobe using Histoacryl/Lipiodol mixture to induce contralateral liver hypertrophy before right-sided (or extended right-sided) hepatectomy in patients with primarily unresectable liver tumors. METHODS: Twenty-one patients (9 females and 12 males) underwent PVE due to an insufficient future liver remnant; 17 showed liver metastases and 4 suffered from biliary cancer. Imaging was performed prior to and 4 weeks after PVE. Surgery was scheduled for 1 week after a CT or MRI control. The primary study end point was technical success, defined as complete angiographical occlusion of the portal vein. The secondary study end point was evaluation of liver hypertrophy by CT and MRI volumetry and transfer to operability. RESULTS: In all the patients, PVE could be performed with a Histoacryl/Lipiodol mixture (n = 20) or a Histoacryl/Lipiodol mixture with microcoils (n = 1). No procedure-related complications occurred. The volume of the left liver lobe increased significantly (p < 0.0001) by 28% from a mean of 549 ml to 709 ml. Eighteen of twenty-one patients (85.7%) could be transferred to surgery, and the intended resection could be performed as planned in 13/18 (72.3%) patients. CONCLUSION: Preoperative right-sided PVE using a Histoacryl/Lipiodol mixture is a safe technique and achieves a sufficient hypertrophy of the future liver remnant in the left liver lobe.

3 Article Covered stents used for late, postpancreatectomy hemorrhage in the common hepatic artery. 2011

Kolokotronis, Theodoros / Hosch, Waldemar / Schmidt, Jan / Radeleff, Boris / Werner, Jens / Weitz, Jürgen / Büchler, Markus. ·Chirurgische Universitätsklinik, Münster, Germany. theodoros.kolokotronis@uni-muenster.de ·Am Surg · Pubmed #21337890.

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