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Pancreatic Neoplasms: HELP
Articles by Claudia Placidi
Based on 1 article published since 2010
(Why 1 article?)
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Between 2010 and 2020, Claudia Placidi wrote the following article about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Review Serotonin-producing enterochromaffin cell tumors of the pancreas: clinicopathologic study of 15 cases and comparison with intestinal enterochromaffin cell tumors. 2011

La Rosa, Stefano / Franzi, Francesca / Albarello, Luca / Schmitt, Anja / Bernasconi, Barbara / Tibiletti, Maria Grazia / Finzi, Giovanna / Placidi, Claudia / Perren, Aurel / Capella, Carlo. ·Department of Pathology, Ospedale di Circolo, Varese, Italy. stefano.larosa@ospedale.varese.it ·Pancreas · Pubmed #21705949.

ABSTRACT: OBJECTIVES: Serotonin-producing tumors of the pancreas are rare endocrine neoplasms composed of enterochromaffin (EC) cells that have been mainly described in the literature as case reports. This study analyzes the clinicopathologic features of a series of pancreatic EC cell neoplasms and their similarities to and differences from intestinal EC cell tumors. METHODS: The morphological, immunohistochemical, ultrastructural, and fluorescent in situ hybridization features of 15 pancreatic and 20 intestinal serotonin-producing neoplasms were compared. In addition, we reviewed the literature on pancreatic serotonin-producing tumors to better understand the clinicopathologic features of this rare tumor type. RESULTS: The lack of substance P and acidic fibroblast growth factor immunoreactivity; the low immunohistochemical expression of CDX2, vesicular monoamine transporter 1, connective tissue growth factor, and prostatic acid phosphatase; the lack of S100-positive sustentacular cells; the strong expression of vesicular monoamine transporter 2; and peculiar ultrastructural features characterize pancreatic EC cell tumors and differentiate them from intestinal ones, although both categories show similar chromosome 18 cytogenetic alterations. The review of the literature indicates that pancreatic functioning tumors associated with the carcinoid syndrome arise in younger patients and are larger, more frequently malignant, and more aggressive neoplasms than pancreatic nonfunctioning ones. CONCLUSIONS: Pancreatic EC cell tumors show several different morphological features compared with related intestinal tumors despite similar cytogenetic alterations on chromosome 18.