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Pancreatic Neoplasms: HELP
Articles by Stefano Partelli
Based on 85 articles published since 2010
(Why 85 articles?)

Between 2010 and 2020, S. Partelli wrote the following 85 articles about Pancreatic Neoplasms.
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4
76 Article Surgical treatment of pancreatic tumors in childhood and adolescence: uncommon neoplasms with favorable outcome. 2011

Marchegiani, Giovanni / Crippa, Stefano / Malleo, Giuseppe / Partelli, Stefano / Capelli, Paola / Pederzoli, Paolo / Falconi, Massimo. ·Department of Surgery, University of Verona, Verona, Italy. ·Pancreatology · Pubmed #21894055.

ABSTRACT: BACKGROUND/AIMS: Pancreatic tumors in children and adolescents are uncommon. The aim of the present paper was to analyze short- and long-term outcomes after surgical treatment of primary pancreatic neoplasms in children and adolescents at a single high-volume center for pancreatic diseases. METHODS: Retrospective review of medical records and pathology reports of patients younger than 18 years who underwent surgery at Verona University Hospital from 1990 through 2010. RESULTS: The study population consisted of 20 patients. Abdominal pain and palpable mass were the most common presenting symptoms. No patient had a locally advanced, unresectable or metastatic disease. Complete resection (R0) was achieved in 19 patients. There was no postoperative mortality, but postoperative complications occurred in 5 cases (25%). Histological examination showed 12 solid pseudopapillary tumors, 5 neuroendocrine tumors, 2 cystadenomas and 1 epithelial malignant tumor. At a median follow-up of 49.5 months (range: 7-234), there was no tumor recurrence. Postoperative diabetes was diagnosed in 1 patient and 4 other patients developed pancreatic exocrine insufficiency. CONCLUSION: In the setting of a high-volume surgical center, radical resection of pancreatic tumors in children and adolescents is associated with acceptable postoperative morbidity and favorable long-term outcome.

77 Article Tumor size correlates with malignancy in nonfunctioning pancreatic endocrine tumor. 2011

Bettini, Rossella / Partelli, Stefano / Boninsegna, Letizia / Capelli, Paola / Crippa, Stefano / Pederzoli, Paolo / Scarpa, Aldo / Falconi, Massimo. ·Department of Surgery, S. Cuore-Don Calabria Hospital, Negrar, Verona, Italy. ·Surgery · Pubmed #21683859.

ABSTRACT: BACKGROUND: Tumor size is a criterion of staging in nonfunctioning pancreatic endocrine tumors as well as a predictor of outcome after curative resection. This study analyzes the correlation between tumor size and malignancy in patients with nonfunctioning pancreatic endocrine tumors. METHODS: All patients with nonfunctioning pancreatic endocrine tumors who underwent curative resection (R0) at our institution between 1990 and 2008 were considered. Their clinicopathologic characteristics were compared among 3 different groups according to tumor size. Univariate and multivariable analyses were performed. RESULTS: Over the study period, 177 patients were identified. Overall, 90 patients (51%) had a tumor size ≤2 cm (group 1), 46 (26%) had tumor size between >2 cm and ≤4 cm (group 2), and 41 (23%) had tumor size >4 cm (group 3). Tumors ≤2 cm were more frequently incidentally discovered (group 1, 57% vs group 2, 51% vs group 3, 32%; P = .014) and benign (group 1, 81% vs group 2, 65% vs group 3, 5%; P < .0001). The presence of a nonfunctioning pancreatic endocrine tumor >2 cm and a nonincidental diagnosis of the tumor were independent predictors of malignancy at multivariable analysis. None of the 51 patients (29%) with a pancreatic endocrine tumor ≤2 cm that was incidentally diagnosed died of disease. CONCLUSION: A strict correlation between tumor size and malignancy in nonfunctioning pancreatic endocrine tumors was demonstrated. A nonoperative management could be advocated for tumors ≤2 cm when discovered incidentally.

78 Article Splenic artery invasion in pancreatic adenocarcinoma of the body and tail: a novel prognostic parameter for patient selection. 2011

Partelli, Stefano / Crippa, Stefano / Barugola, Giuliano / Tamburrino, Domenico / Capelli, Paola / D'Onofrio, Mirko / Pederzoli, Paolo / Falconi, Massimo. ·Department of Surgery, University of Verona, Verona, Italy. ·Ann Surg Oncol · Pubmed #21584836.

ABSTRACT: BACKGROUND: The value of splenic vessels invasion (which identified T3 tumors) in prognosis after resection for pancreatic ductal adenocarcinoma (PDA) of the body and tail has not been extensively investigated. The goal of this study was to evaluate prognostic factors in PDA of the body/tail, emphasizing the role of splenic vessels infiltration. METHODS: Between 1990 and 2008, 87 patients who underwent distal pancreatectomy (DP) for histologically proven PDA of the body and tail were analyzed. Clinicopathological prognostic factors for survival were evaluated. Univariate and multivariable analyses were performed. RESULTS: Postoperative morbidity was 31% with no mortality. The 1-, 3-, and 5-year overall survival rates were 77%, 48%, and 24.5%, respectively. Invasion of the splenic artery (SA) was observed in 19 patients (22%). Patients with SA invasion had a significantly poorer prognosis compared with those without SA invasion (median survival: 15 vs. 39 months, P = 0.014). On multivariable analysis, adjuvant therapy, poor differentiation (G3/G4), R2 resection, the presence of lymph node metastases, and SA invasion were independent predictors of survival. CONCLUSIONS: Along with other well-known prognostic factors, invasion of SA is an independent predictor of poor survival in PDA of the body/tail. In case of the presence of SA infiltration, neoadjuvant treatment should be considered. SA infiltration might be reclassified from a T3 to T4 tumor.

79 Article Perioperative and long-term results after left pancreatectomy: a single-institution, non-randomized, comparative study between open and laparoscopic approach. 2011

Butturini, Giovanni / Partelli, Stefano / Crippa, Stefano / Malleo, Giuseppe / Rossini, Roberto / Casetti, Luca / Melotti, Gian Luigi / Piccoli, Micaela / Pederzoli, Paolo / Bassi, Claudio. ·Department of Surgery, G.B. Rossi Hospital, University of Verona, P.Le L.A. Scuro 10, 37134 Verona, Italy. giovanni.butturini@ospedaleuniverona.it ·Surg Endosc · Pubmed #21424200.

ABSTRACT: BACKGROUND: Laparoscopic left pancreatic resections are being increasingly performed. In this study, we provide a nonrandomized comparison between laparoscopic and open left pancreatectomy (OLP) for benign and borderline tumors, focusing on both perioperative and long-term results. METHODS: Demographic, pathologic, and perioperative details from patients who underwent laparoscopic and OLP between 1999 and 2006 were retrieved from our database and analyzed. Long-term results, including resume to full-time work, occurrence of incisional hernias, and incidence of exocrine and endocrine insufficiency also were evaluated. RESULTS: A total of 116 patients were included in the analysis; 43 (37.1%) were managed laparoscopically and 73 (62.9%) underwent the open procedure. There were no significant differences regarding clinical and pathological data. All of the resections attempted laparoscopically were completed. The rate of splenic preservation was significantly higher in the laparoscopic group (P = 0.0001). Postoperative outcomes were similar between the two groups. Longitudinal comparison between two time periods (1999-June 2004 vs. July 2004-2006) showed that pancreatic fistula and hospital stay significantly diminished over time in the laparoscopic group (P = 0.04 and P = 0.004, respectively). Median follow-up was 53 months. The incidence of exocrine insufficiency and incisional hernias was significantly higher after open resections (both P = 0.05). After hospital discharge, median time to resume full-time work was 6 weeks in the open group and 3 weeks after laparoscopic resections (P < 0.0001). Laparoscopy also resulted as an independent factor for an early resume to full-time activities in the multivariate analysis (P < 0.0001). CONCLUSIONS: Laparoscopic left pancreatectomy is a safe procedure for benign and borderline tumors, with similar perioperative outcomes compared with the open procedure. In the long term, the laparoscopic approach is likely to be superior thanks to a more rapid resume of full-time activities and to the lower incidence of incisional hernias and exocrine insufficiency. Clearly, these results have yet to be confirmed in large, randomized trials.

80 Article Total pancreatectomy: indications, different timing, and perioperative and long-term outcomes. 2011

Crippa, Stefano / Tamburrino, Domenico / Partelli, Stefano / Salvia, Roberto / Germenia, Silvia / Bassi, Claudio / Pederzoli, Paolo / Falconi, Massimo. ·Department of Surgery, Chirurgia Generale B - Pancreas Unit, Policlinico GB Rossi, University of Verona, Verona, Italy. ·Surgery · Pubmed #20494386.

ABSTRACT: BACKGROUND: Total pancreatectomy (TP) has been performed rarely in the past because of its high morbidity and mortality. Because outcomes of pancreatic surgery as well as management of pancreatic insufficiency have improved markedly, enthusiasm for TP has an increased. METHODS: Between 1996 and 2008, 65 patients (33 females, 32 males; median age, 63 years) underwent TP at a single, high-volume center. Indications, timing, and perioperative and long-term results were analyzed. RESULTS: Twenty-five patients (38.5%) underwent a planned, elective TP and 25 patients underwent a single-stage unplanned TP after an initial partial pancreatectomy that required TP because of intraoperative hemorrhage (n = 1) or positive pancreatic resection margin (n = 24). The remaining 15 patients (23%) underwent a 2-stage pancreatectomy for tumor recurrence in the remnant. No completion TP for postoperative complications were performed. There was no mortality; the overall morbidity was 39% and the reoperation rate was 5%. Overall, 48% of patients had intraductal papillary mucinous neoplasms, and 29% pancreatic ductal adenocarcinoma. The R1 resection rate was 12%. Four of 23 patients (17%) who underwent single-stage, unplanned TP for positive resection margin had R1 resection (positive retroperitoneal margin). The median follow-up was 34 months. The overall 5-year survival was 71%. No deaths owing to hypoglycemia were observed. Median insulin was 32 U/d, and the median lipase was 80,000 U/d. CONCLUSION: TP can be performed safely with no mortality and acceptable morbidity. Postoperative pancreatic insufficiency can be managed safely. To achieve an R0 during TP, both the resection and retroperitoneal margin should be evaluated intraoperatively. TP is an effective operation in selected patients.

81 Article Pancreatic cystic endocrine tumors: a different morphological entity associated with a less aggressive behavior. 2010

Boninsegna, Letizia / Partelli, Stefano / D'Innocenzio, Maria Michela / Capelli, Paola / Scarpa, Aldo / Bassi, Claudio / Pederzoli, Paolo / Falconi, Massimo. ·Department of Surgery, S. Cuore-Don Calabria Hospital, Negrar, Italy. ·Neuroendocrinology · Pubmed #20689265.

ABSTRACT: BACKGROUND: Cystic pancreatic endocrine tumors (CPETs) are rare lesions and their biological features have been scarcely investigated. AIM: To compare clinical and pathological features of resected non-functioning sporadic CPETs (NF-CPETs) with solid pancreatic endocrine tumors (SPETs) in a single-institution experience. METHODS: All patients with a pathologically confirmed diagnosis of sporadic non-functioning pancreatic endocrine tumors who underwent curative resection between 1990 and 2008 were included. A comparison of demographic, clinical and pathological characteristics between CPETs and SPETs was made. Univariate and multivariable analyses were performed to identify preoperative predictors of carcinoma (non-functioning pancreatic endocrine carcinoma). RESULTS: Twenty-one (11.5%) patients with a histological diagnosis of NF-CPET were identified. The median age was 60 years (IQR 46.5-73.5 years) and a diagnosis of carcinoma (non-functioning pancreatic endocrine carcinoma) was made in 3 (14.3%) cases. In the comparison with NF-SPETs, no differences were found in terms of gender (p = 0.75), age (p = 0.81), presenting symptoms (p = 0.43), localization of the tumors (p = 0.46) and type of resection (p = 0.31). The incidence of non-functioning pancreatic endocrine carcinoma was significantly lower in the NF-CPET versus the NF-SPET group (14.3 vs. 40.4%, p = 0.04). By univariate analysis, preoperative predictors of non-functioning pancreatic endocrine carcinoma included the presence of symptoms (OR 3.96, 95% CI 2.06-7.63) and an increase in the absolute value of radiological diameter (OR 1.05, 95% CI 1.03-1.07). A cystic morphology of the lesion turned out to be a negative predictor of carcinoma (OR 0.25, 95% CI 0.70-0.87). These results were confirmed by multivariable analysis. CONCLUSIONS: NF-CPETs have a measurable propensity to be benign. In those patients affected by small and asymptomatic NF-CPET a more conservative surgical approach or a follow-up policy could be considered.

82 Article Invasive intraductal papillary mucinous carcinomas of the pancreas: predictors of survival and the role of lymph node ratio. 2010

Partelli, Stefano / Fernandez-Del Castillo, Carlos / Bassi, Claudio / Mantovani, William / Thayer, Sarah P / Crippa, Stefano / Ferrone, Cristina R / Falconi, Massimo / Pederzoli, Paolo / Warshaw, Andrew L / Salvia, Roberto. ·Department of Surgery, University of Verona, Verona, Italy. ·Ann Surg · Pubmed #20142730.

ABSTRACT: INTRODUCTION: Intraductal papillary mucinous neoplasms (IPMNs) are being increasingly recognized, and often harbor cancer. Lymph node metastases are an important prognostic factor for patients with invasive intraductal papillary carcinoma (I-IPMC), but the role of lymph node ratio (LNR) in predicting survival after surgery for I-IPMC is unknown. METHODS: The combined databases from the Surgical Department of Massachusetts General Hospital of Boston and the University of Verona were queried. We retrospectively reviewed clinical and pathologic data of all patients with resected, pathologically confirmed, I-IPMC between 1990 and 2007. Univariate and multivariate analysis were performed. RESULTS: I-IPMCs were diagnosed in 104 patients (55 males and 49 females), median age was 69 years. Recurrent disease was identified in 49 patients (47.1%) and the median 5-year disease specific survival (DSS) was 60.1%. The median number of resected/evaluated nodes was 15 (range, 5-60). There were 60 (57.7%) patients who had negative lymph nodes (N0), whereas 44 (42.3%) had lymph node metastases (N1). Patients with lymph node metastases had a shorter 5-year DSS (28.9%) compared with patients with negative lymph nodes (80.3%; P < 0.05) As the LNR increased, 5-year DSS decreased (LNR = 0, 86.5%; LNR >0 to 0.2, 34.4%; LNR >0.2, 11.1%; P < 0.05). On multivariate analysis, LNR, the presence of a family history of pancreatic cancer and a preoperative value of Ca 19.9 > 37 U/L were significant predictors of survival (P < 0.05). CONCLUSIONS: Lymph node ratio is a strong predictor of survival after resection for invasive intraductal papillary mucinous carcinoma.

83 Minor Pancreatic Ductal Adenocarcinoma: A New TNM Staging System is Needed! 2017

Crippa, Stefano / Partelli, Stefano / Falconi, Massimo. ·*Division of Pancreatic Surgery, IRCCS San Raffaele Hospital, Milan, Italy †Clinical and Translational Research Program on Pancreatic Cancer, IRCCS San Raffaele Hospital, Milan, Italy. ·Ann Surg · Pubmed #27455151.

ABSTRACT: -- No abstract --

84 Minor Questions about branch-duct IPMNs with Sendai negative criteria. 2014

Crippa, Stefano / Partelli, Stefano / Falconi, Massimo. ·Division of Pancreatic Surgery Università Politecnica delle Marche Academic Hospital "Ospedali Riuniti" Ancona, Italy. ·Ann Surg · Pubmed #24253153.

ABSTRACT: -- No abstract --

85 Minor Implications of the new histological classification (WHO 2010) for pancreatic neuroendocrine neoplasms. 2012

Crippa, S / Partelli, S / Boninsegna, L / Falconi, M. · ·Ann Oncol · Pubmed #22753260.

ABSTRACT: -- No abstract --