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Pancreatic Neoplasms: HELP
Articles by Hai V. Nguyen
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, Hai V. Nguyen wrote the following 2 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article MicroRNA Expression in a Readily Accessible Common Hepatic Artery Lymph Node Predicts Time to Pancreatic Cancer Recurrence Postresection. 2016

Nguyen, Hai V / Gore, Jesse / Zhong, Xin / Savant, Sudha S / Deitz-McElyea, Samantha / Schmidt, C Max / House, Michael G / Korc, Murray. ·Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. · Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. · The Pancreatic Cancer Signature Center, Indiana University Simon Cancer Center, Indianapolis, IN, 46202, USA. · Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. · Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. mkorc@iu.edu. · The Pancreatic Cancer Signature Center, Indiana University Simon Cancer Center, Indianapolis, IN, 46202, USA. mkorc@iu.edu. · Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. mkorc@iu.edu. · IU Simon Cancer Center, Indiana University School of Medicine, 980 West Walnut Street, Rm 528, Indianapolis, IN, 46202, USA. mkorc@iu.edu. ·J Gastrointest Surg · Pubmed #27456015.

ABSTRACT: Lymph node involvement in pancreatic adenocarcinoma (PAC) predicts postresection survival, but early lymph node metastasis detection is not easily accomplished. We assessed a panel of microRNAs (miRNAs) in a common hepatic artery lymph node (station 8) that is readily accessible during pancreatoduodenectomy (PD) to determine if increased miRNA levels correlate with postresection recurrence. Station 8 lymph nodes overlying the common hepatic artery collected during PD were assayed for miRNA-10b, miRNA-30c, miRNA-21, and miRNA-155 and cytokeratin-19 (CK19), an epithelial cell marker, using quantitative PCR. Expression was correlated with disease recurrence, recurrence-free survival (RFS), and overall survival (OS). Station 8 lymph nodes from 37 patients (30 periampullary carcinomas (PCs), 2 chronic pancreatitis, 5 other cancers) exhibited increased miRNA-10b levels in 14/30 PCs, and in 10 of these 14 patients, cancer recurred during the study period (2012-2015). High miRNA-10b was also associated with shorter RFS (42.5 vs. 92.4 weeks, p < 0.05) but not OS, whereas miRNA-30c, miRNA-21, and miRNA-155 levels and CK19 mRNA levels in station 8 nodes were variable and did not correlate with RFS or OS. We conclude that elevated miRNA-10b levels in station 8 lymph nodes could be utilized to assess risk for early disease progression in patients with periampullary tumors.

2 Article TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis. 2015

Gore, Jesse / Craven, Kelly E / Wilson, Julie L / Cote, Gregory A / Cheng, Monica / Nguyen, Hai V / Cramer, Harvey M / Sherman, Stuart / Korc, Murray. ·Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. · The Melvin and Bren Simon Cancer Center, and The Center for Pancreatic Cancer Research, Indianapolis, IN 46202, USA. · Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. · Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. · Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA. · Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. ·Oncotarget · Pubmed #25762644.

ABSTRACT: Pancreatic ductal adenocarcinomas (PDACs) overexpress pro-angiogenic factors but are not viewed as vascular. Using data from The Cancer Genome Atlas we demonstrate that a subset of PDACs exhibits a strong pro-angiogenic signature that includes 37 genes, such as HDAC9, that are overexpressed in PDAC arising in KRC mice, which express mutated Kras and lack RB. Moreover, patient-derived orthotopic xenografts can exhibit tumor angiogenesis, whereas conditioned media (CM) from KRC-derived pancreatic cancer cells (PCCs) enhance endothelial cell (EC) growth and migration, and activate canonical TGF-β signaling and STAT3. Inhibition of the type I TGF-β receptor with SB505124 does not alter endothelial activation in vitro, but decreases pro-angiogenic gene expression and suppresses angiogenesis in vivo. Conversely, STAT3 silencing or JAK1-2 inhibition with ruxolitinib blocks CM-enhanced EC proliferation. STAT3 disruption also suppresses endothelial HDAC9 and blocks CM-induced HDAC9 expression, whereas HDAC9 re-expression restores CM-enhanced endothelial proliferation. Moreover, ruxolitinib blocks mitogenic EC/PCC cross-talk, and suppresses endothelial p-STAT3 and HDAC9, and PDAC progression and angiogenesis in vivo, while markedly prolonging survival of KRC mice. Thus, targeting JAK1-2 with ruxolitinib blocks a final pathway that is common to multiple pro-angiogenic factors, suppresses EC-mediated PCC proliferation, and may be useful in PDACs with a strong pro-angiogenic signature.