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Pancreatic Neoplasms: HELP
Articles by Alexandra M. Moore
Based on 3 articles published since 2010
(Why 3 articles?)
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Between 2010 and 2020, Alexandra Moore wrote the following 3 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression. 2020

Kim, Stephanie S / Xu, Shili / Cui, Jing / Poddar, Soumya / Le, Thuc M / Hayrapetyan, Hovhannes / Li, Luyi / Wu, Nanping / Moore, Alexandra M / Zhou, Lei / Yu, Alice C / Dann, Amanda M / Elliott, Irmina A / Abt, Evan R / Kim, Woosuk / Dawson, David W / Radu, Caius G / Donahue, Timothy R. ·Department of Surgery, UCLA, Los Angeles, CA, 90095, USA. · Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Hubei 430022, China. · Ahmanson Translational Imaging Division, UCLA, Los Angeles, CA, 90095, USA. · Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, 90095, USA. · Department of Pancreatic and Thyroidal Surgery, Shengjing Hospital, China Medical University, Shenyang 110003, China. · Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, USA. · Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, 90095, USA. · David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA. ·Theranostics · Pubmed #31903153.

ABSTRACT: Arginine (Arg) deprivation is a promising therapeutic approach for tumors with low argininosuccinate synthetase 1 (ASS1) expression. However, its efficacy as a single agent therapy needs to be improved as resistance is frequently observed.

2 Article Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion. 2019

Elliott, Irmina A / Dann, Amanda M / Xu, Shili / Kim, Stephanie S / Abt, Evan R / Kim, Woosuk / Poddar, Soumya / Moore, Alexandra / Zhou, Lei / Williams, Jennifer L / Capri, Joseph R / Ghukasyan, Razmik / Matsumura, Cynthia / Tucker, D Andrew / Armstrong, Wesley R / Cabebe, Anthony E / Wu, Nanping / Li, Luyi / Le, Thuc M / Radu, Caius G / Donahue, Timothy R. ·Department of Surgery, University of California, Los Angeles, CA 90095. · Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095. · Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095. · Department of Pancreatic and Thyroidal Surgery, Shengjing Hospital, China Medical University, Shenyang 110003, China. · Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA 90502. · David Geffen School of Medicine, University of California, Los Angeles, CA 90095. · Department of Surgery, University of California, Los Angeles, CA 90095; cradu@mednet.ucla.edu TDonahue@mednet.ucla.edu. · Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095. ·Proc Natl Acad Sci U S A · Pubmed #30894490.

ABSTRACT: Functional lysosomes mediate autophagy and macropinocytosis for nutrient acquisition. Pancreatic ductal adenocarcinoma (PDAC) tumors exhibit high basal lysosomal activity, and inhibition of lysosome function suppresses PDAC cell proliferation and tumor growth. However, the codependencies induced by lysosomal inhibition in PDAC have not been systematically explored. We performed a comprehensive pharmacological inhibition screen of the protein kinome and found that replication stress response (RSR) inhibitors were synthetically lethal with chloroquine (CQ) in PDAC cells. CQ treatment reduced de novo nucleotide biosynthesis and induced replication stress. We found that CQ treatment caused mitochondrial dysfunction and depletion of aspartate, an essential precursor for de novo nucleotide synthesis, as an underlying mechanism. Supplementation with aspartate partially rescued the phenotypes induced by CQ. The synergy of CQ and the RSR inhibitor VE-822 was comprehensively validated in both 2D and 3D cultures of PDAC cell lines, a heterotypic spheroid culture with cancer-associated fibroblasts, and in vivo xenograft and syngeneic PDAC mouse models. These results indicate a codependency on functional lysosomes and RSR in PDAC and support the translational potential of the combination of CQ and RSR inhibitors.

3 Unspecified Pancreatic Cancer. 2019

Moore, Alexandra / Donahue, Timothy. ·University of California, Los Angeles. ·JAMA · Pubmed #31593274.

ABSTRACT: -- No abstract --