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Pancreatic Neoplasms: HELP
Articles by Maria Fernanda Montiel
Based on 5 articles published since 2010
(Why 5 articles?)
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Between 2010 and 2020, Maria Montiel wrote the following 5 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes. 2019

Riquelme, Erick / Zhang, Yu / Zhang, Liangliang / Montiel, Maria / Zoltan, Michelle / Dong, Wenli / Quesada, Pompeyo / Sahin, Ismet / Chandra, Vidhi / San Lucas, Anthony / Scheet, Paul / Xu, Hanwen / Hanash, Samir M / Feng, Lei / Burks, Jared K / Do, Kim-Anh / Peterson, Christine B / Nejman, Deborah / Tzeng, Ching-Wei D / Kim, Michael P / Sears, Cynthia L / Ajami, Nadim / Petrosino, Joseph / Wood, Laura D / Maitra, Anirban / Straussman, Ravid / Katz, Matthew / White, James Robert / Jenq, Robert / Wargo, Jennifer / McAllister, Florencia. ·Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Center for Integrative Biology, Faculty of Science, Universidad Mayor, Santiago, Chile. · Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. · Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. · Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. · Department of Engineering, Texas Southern University, Houston, TX, USA. · Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. · Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; McCombs Institute for the Early Detection and Treatment of Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. · Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. · Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. · Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. · Departments of Medicine, Oncology and Molecular Microbiology & Immunology, Johns Hopkins University School of Medicine and the Bloomberg School of Public Health, Baltimore, MD, USA. · Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA. · Department of Pathology and The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. · Sheikh Ahmed Pancreatic Cancer Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. · Resphera Biosciences, Baltimore, MD, USA. · Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. · Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. · Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Clinical Cancer Genetics Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: fmcallister@mdanderson.org. ·Cell · Pubmed #31398337.

ABSTRACT: Most patients diagnosed with resected pancreatic adenocarcinoma (PDAC) survive less than 5 years, but a minor subset survives longer. Here, we dissect the role of the tumor microbiota and the immune system in influencing long-term survival. Using 16S rRNA gene sequencing, we analyzed the tumor microbiome composition in PDAC patients with short-term survival (STS) and long-term survival (LTS). We found higher alpha-diversity in the tumor microbiome of LTS patients and identified an intra-tumoral microbiome signature (Pseudoxanthomonas-Streptomyces-Saccharopolyspora-Bacillus clausii) highly predictive of long-term survivorship in both discovery and validation cohorts. Through human-into-mice fecal microbiota transplantation (FMT) experiments from STS, LTS, or control donors, we were able to differentially modulate the tumor microbiome and affect tumor growth as well as tumor immune infiltration. Our study demonstrates that PDAC microbiome composition, which cross-talks to the gut microbiome, influences the host immune response and natural history of the disease.

2 Article High Prevalence of Hereditary Cancer Syndromes and Outcomes in Adults with Early-Onset Pancreatic Cancer. 2018

Bannon, Sarah A / Montiel, Maria F / Goldstein, Jennifer B / Dong, Wenli / Mork, Maureen E / Borras, Ester / Hasanov, Merve / Varadhachary, Gauri R / Maitra, Anirban / Katz, Matthew H / Feng, Lei / Futreal, Andrew / Fogelman, David R / Vilar, Eduardo / McAllister, Florencia. ·Clinical Cancer Genetics Program, The University of Texas MD Anderson Cancer Center, Houston, Texas. · Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas. · Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. · Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas. · Internal Medicine Department, The University of Texas Health Science Center at Houston, Houston, Texas. · Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. · Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. · Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. · Clinical Cancer Genetics Program, The University of Texas MD Anderson Cancer Center, Houston, Texas. fmcallister@mdanderson.org. ·Cancer Prev Res (Phila) · Pubmed #30274973.

ABSTRACT:

3 Article Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells. 2018

Zhang, Yu / Zoltan, Michelle / Riquelme, Erick / Xu, Hanwen / Sahin, Ismet / Castro-Pando, Susana / Montiel, Maria Fernanda / Chang, Kyle / Jiang, Zhengyu / Ling, Jianhua / Gupta, Sonal / Horne, William / Pruski, Melissa / Wang, Huamin / Sun, Shao-Cong / Lozano, Guillermina / Chiao, Paul / Maitra, Anirban / Leach, Steven D / Kolls, Jay K / Vilar, Eduardo / Wang, Timothy C / Bailey, Jennifer M / McAllister, Florencia. ·Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas. · Department of Engineering, Texas Southern University, Houston, Texas. · Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York. · Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. · Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas. · Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania. · Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, University of Texas Health Science Center, Houston, Texas. · Department of Immunology, University of Texas Health Sciences Center, Houston, Texas. · Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. · Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York. · Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: fmcallister@mdanderson.org. ·Gastroenterology · Pubmed #29604293.

ABSTRACT: BACKGROUND & AIMS: Little is known about how the immune system affects stem cell features of pancreatic cancer cells. Immune cells that produce interleukin 17A (IL17A) in the chronically inflamed pancreas (chronic pancreatitis) contribute to pancreatic interepithelial neoplasia (PanIN) initiation and progression. We investigated the effects that IL17A signaling exerts on pancreatic cancer progenitor cells and the clinical relevance of this phenomena. METHODS: We performed studies with Mist1Cre;LSLKras;Rosa26mTmG (KC RESULTS: PanIN cells from KC CONCLUSIONS: In studies of mouse and human pancreatic tumors and precursors, we found that immune cell-derived IL17 regulated development of tuft cells and stem cell features of pancreatic cancer cells via increased expression of DCLK1, POU2F3, ALDH1A1, and IL17RC. Strategies to disrupt this pathway might be developed to prevent pancreatic tumor growth and progression.

4 Article Current Status and Future Directions for Screening Patients at High Risk for Pancreatic Cancer. 2017

McAllister, Florencia / Montiel, Maria F / Uberoi, Guneesh S / Uberoi, Angad S / Maitra, Anirban / Bhutani, Manoop S. ·Dr McAllister is an assistant professor and Dr Montiel is a research investigator in the Department of Clinical Cancer Prevention; Dr Guneesh S. Uberoi and Dr Angad S. Uberoi are research interns and Dr Bhutani is a professor in the Department of Gastroenterology, Hepatology, and Nutrition; and Dr Maitra is a professor in the Department of Pathology at the University of Texas MD Anderson Cancer Center in Houston, Texas. ·Gastroenterol Hepatol (N Y) · Pubmed #28656024.

ABSTRACT: It is well known that pancreatic ductal adenocarcinoma has a high mortality rate. Despite progress in understanding the biology and genetic basis of this disease, life expectancy has changed minimally in the last 50 years. This article highlights the importance of screening patients at high risk for developing pancreatic cancer and reviews current methods as well as methods in development for pancreatic cancer early detection and surveillance.

5 Minor Pancreatic Cancer Early Detection and Interception in an Atypical Case of Peutz-Jeghers Syndrome. 2019

Mork, Maureen / Quesada, Pompeyo R / Bannon, Sarah / Montiel, Maria F / Fleming, Jason B / Lynch, Patrick M / Bhutani, Manoop S / Lee, Jeffrey H / McAllister, Florencia. ·Clinical Cancer Genetics Program The University of Texas MD Anderson Cancer Center Houston, TX Department of Clinical Cancer Prevention The University of Texas MD Anderson Cancer Center Houston, TX Clinical Cancer Genetics Program The University of Texas MD Anderson Cancer Center Houston, TX Department of Clinical Cancer Prevention The University of Texas MD Anderson Cancer Center Houston, TX Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston, TX Department of Gastroenterology The University of Texas MD Anderson Cancer Center Houston, TX Clinical Cancer Genetics Program Departments of Clinical Cancer Prevention and GI Medical Oncology The University of Texas MD Anderson Cancer Center Houston, TX fmcallister@mdanderson.org. ·Pancreas · Pubmed #30973470.

ABSTRACT: -- No abstract --