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Pancreatic Neoplasms: HELP
Articles by Francesco Marini
Based on 2 articles published since 2008
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Between 2008 and 2019, Francesco Marini wrote the following 2 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Pre-operative Diagnosis of Pancreatic Neuroendocrine Tumors with Endoscopic Ultrasonography and Computed Tomography in a Large Series. 2016

Manta, Raffaele / Nardi, Elisabetta / Pagano, Nico / Ricci, Claudio / Sica, Mariano / Castellani, Danilo / Bertani, Helga / Piccoli, Micaela / Mullineris, Barbara / Tringali, Alberto / Marini, Francesco / Germani, Ugo / Villanacci, Vincenzo / Casadei, Riccardo / Mutignani, Massimiliano / Conigliaro, Rita / Bassotti, Gabrio / Zullo, Angelo. ·Gastroenterology and Digestive Endoscopy Unit, Nuovo Ospedale Civile Sant'Agostino-Estense, Baggiovara-Modena, Italy. r.manta@libero.it. · Gastroenterology Section, Department of Medicine, University of Perugia School of Medicine, Perugia, Italy. · Department of Internal Medicine and Surgery (DIMEC), University of Bologna, Sant'Orsola-Malpighi Hospital, Bologna, Italy. · Gastroenterology and Digestive Endoscopy Unit, Nuovo Ospedale Civile Sant'Agostino-Estense, Baggiovara-Modena, Italy. · Department of General Surgery, Nuovo Ospedale Civile Sant'Agostino-Estense, Baggiovara-Modena, Italy. · Endoscopy Unit, Niguarda Ca-Granda Hospital, Milan, Italy. · Gastroenterology Unit, Ospedali Riuniti Ancona, Italy. · Pathology Unit Spedali Civili, Brescia, Italy. · Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy. ·J Gastrointestin Liver Dis · Pubmed #27689195.

ABSTRACT: BACKGROUND AND AIMS: Diagnosis of pancreatic neuroendocrine tumors (p-NETs) is frequently challenging. We describe a large series of patients with p-NETs in whom both pre-operative Computed Tomography (CT) and Endoscopic Ultrasonography (EUS) were performed. METHODS: This was a retrospective analysis of prospectively collected sporadic p-NET cases. All patients underwent both standard multidetector CT study and EUS with fine-needle aspiration (FNA). The final histological diagnosis was achieved on a post-surgical specimen. Chromogranin A (CgA) levels were measured. RESULTS: A total of 80 patients (mean age: 58 +/- 14.2 years; males: 42) were enrolled. The diameter of functioning was significantly lower than that of non-functioning p-NETs (11.2 +/- 8.5 mm vs 19.8 +/- 12.2 mm; P = 0.0004). The CgA levels were more frequently elevated in non-functioning than functioning pNET patients (71.4% vs 46.9%; P = 0.049). Overall, the CT study detected the lesion in 51 (63.7%) cases, being negative in 26 (68.4%) patients with a tumor Data of this large case series would suggest that the EUS should be included in the diagnostic work-up in all patients with a suspected p-NET, even when the CT study was negative for a primary lesion in the pancreas.

2 Article PDX-1 mRNA expression in endoscopic ultrasound-guided fine needle cytoaspirate: perspectives in the diagnosis of pancreatic cancer. 2015

Marzioni, Marco / Germani, Ugo / Agostinelli, Laura / Bedogni, Giorgio / Saccomanno, Stefania / Marini, Francesco / Bellentani, Stefano / Barbera, Carmelo / De Minicis, Samuele / Rychlicki, Chiara / Santinelli, Alfredo / Ferretti, Maurizio / Di Maira, Pier Vittorio / Baroni, Gianluca Svegliati / Benedetti, Antonio / Caletti, Giancarlo / Lorenzini, Ivano / Fusaroli, Pietro. ·Clinic of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy. Electronic address: m.marzioni@univpm.it. · Division of Gastroenterology, Azienda Ospedaliero Universitaria "Ospedali Riuniti", Ancona, Italy. · Clinic of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy. · Epidemiology Unit, Centro Studi Fegato, Trieste, Italy. · Servizio di Gastroenterologia - Ospedale "Ramazzini" Carpi, Modena, Italy. · Institute of Pathologic Anatomy, Università Politecnica delle Marche, Ancona, Italy. · Division of Cytopathology, Azienda Ospedaliero Universitaria "Ospedali Riuniti", Ancona, Italy. · Division of Gastroenterology and Digestive Endoscopy, Università degli Studi di Bologna, Castel San Pietro Terme Hospital, Castel San Pietro Terme, Italy. ·Dig Liver Dis · Pubmed #25454709.

ABSTRACT: BACKGROUND AND AIMS: Endoscopic ultrasound-guided fine needle aspiration is routinely used in the diagnostic work up of pancreatic cancer but has a low sensitivity. Studies showed that Pancreatic Duodenal Homeobox-1 (PDX-1) is expressed in pancreatic cancer, which is associated with a worse prognosis. We aimed to verify whether the assessment of PDX-1 in endoscopic ultrasound-guided fine needle aspiration samples may be helpful for the diagnosis of pancreatic cancer. METHODS: mRNA of 54 pancreatic cancer and 25 cystic lesions was extracted. PDX-1 expression was assessed by Real-Time PCR. RESULTS: In all but two patients with pancreatic cancer, PDX-1 was expressed and was found positive in 7 patients with pancreatic cancer in which cytology was negative. The positivity was associated with a probability of 0.98 (95% CI 0.90-1.00) of having cancer and the negativity with one of 0.08 (95% CI 0.01-0.27). The probability of cancer rose to 1.00 (95% CI 0.97-1.00) for patients positive to both PDX-1 and cytology and fell to 0.0 (95% CI 0.00-0.15) in patients negative for both. CONCLUSIONS: PDX-1mRNA is detectable in samples of pancreatic cancer. Its quantification may be helpful to improve the diagnosis of pancreatic cancer.