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Pancreatic Neoplasms: HELP
Articles by Dimitrios K. Manatakis
Based on 1 article published since 2010
(Why 1 article?)

Between 2010 and 2020, Dimitrios K. Manatakis wrote the following article about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Article Adult pancreatoblastoma: A case report and review of the literature. 2015

Zouros, Efstratios / Manatakis, Dimitrios K / Delis, Spiros G / Agalianos, Christos / Triantopoulou, Charina / Dervenis, Christos. ·Department of Surgery, Konstantopouleio General Hospital, Nea Ionia, Athens 14233, Greece. · Department of Radiology, Konstantopouleio General Hospital, Nea Ionia, Athens 14233, Greece. ·Oncol Lett · Pubmed #26137059.

ABSTRACT: The present study describes the case of a 24-year-old patient who presented with obstructive jaundice and weight loss, and was diagnosed with pancreatoblastoma (PB). Abdominal imaging studies revealed a heterogenous lesion of the pancreatic head with dilatation of the common bile duct. The patient underwent pancreaticoduodenectomy, however, three months after surgery multiple liver and bone metastases were identified on follow-up computed tomography scans. Despite treatment with four cycles of systemic chemotherapy and five courses of radiofrequency ablation, the patient succumbed due to tumour dissemination 13 months after initial diagnosis. PB is a malignant tumour of the pancreas that typically occurs in the pediatric population. The aim of the present study was to highlight the aggressive behavior of this rare clinical entity, focusing on the pitfalls of pre-operative diagnosis and the lack of management strategy guidelines in adults. Preoperative diagnosis of PB based on radiographic features may be difficult, as the imaging characteristics are non-specific. Furthermore, cytology may also be misleading, as the neoplasm consists of multiple cell lines (acinar, ductal and neuroendocrine cells) and diagnosis depends largely on the identification of the distinctive histological characteristic of squamoid corpuscles, which present as nests of flattened cells with a squamous appearance. Despite the use of surgical resection and adjuvant chemoradiotherapy for the treatment of this malignancy, its aggressive nature means that PB is associated with a poor prognosis in adult patients.