Pick Topic
Review Topic
List Experts
Examine Expert
Save Expert
  Site Guide ··   
Pancreatic Neoplasms: HELP
Articles by Vincent Madonia
Based on 1 article published since 2010
(Why 1 article?)
||||

Between 2010 and 2020, Vincent Madonia wrote the following article about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article The oral microbiota in patients with pancreatic cancer, patients with IPMNs, and controls: a pilot study. 2017

Olson, Sara H / Satagopan, Jaya / Xu, Youming / Ling, Lilan / Leong, Siok / Orlow, Irene / Saldia, Amethyst / Li, Peter / Nunes, Pamela / Madonia, Vincent / Allen, Peter J / O'Reilly, Eileen / Pamer, Eric / Kurtz, Robert C. ·Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 485 Lexington Avenue, New York, NY, 10021, USA. olsons@mskcc.org. · Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 485 Lexington Avenue, New York, NY, 10021, USA. · Department of Epidemiology and Public Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA. · Department of Medicine, Memorial Sloan Kettering Cancer Center, 417 East 68 Street, New York, NY, 10065, USA. · Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1250 First Avenue, New York, NY, 10065, USA. · New York University School of Medicine, 550 First Avenue, New York, NY, 10016, USA. · Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. · Department of Medicine, Memorial Sloan Kettering Cancer Center, 300 East 66 Street, New York, NY, 10065, USA. · Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. ·Cancer Causes Control · Pubmed #28762074.

ABSTRACT: PURPOSE: Poor oral health appears to be a risk factor for pancreatic cancer, possibly implicating the oral microbiota. In this pilot study, we evaluated the characteristics of the oral microbiota in patients with pancreatic ductal adenocarcinoma (PDAC), intraductal papillary mucinous neoplasms (IPMN), and healthy controls. METHODS: Forty newly diagnosed PDAC patients, 39 IPMN patients, and 58 controls, excluding current smokers and users of antibiotics, provided saliva samples. Common oral bacterial species were comprehensively surveyed by sequencing of the 16S rRNA microbial genes. We obtained measures of diversity and the mean relative proportions of individual taxa. We explored the degree to which these measures differed according to respondent characteristics based on individual interviews. RESULTS: PDAC cases did not differ in diversity measures from either controls or IPMN cases. PDAC cases had higher mean relative proportions of Firmicutes and related taxa, while controls had higher mean relative proportions of Proteobacteria and related taxa. Results were generally similar when comparing PDAC to IPMN cases. Among IPMNs and controls combined, younger individuals had higher levels of several taxa within the Proteobacteria. The only other variable consistently related to mean relative proportions was mouthwash use, with taxa within Firmicutes more common among users. CONCLUSIONS: While there were no differences in diversity of the oral microbiota among these groups, there were differences in the mean relative proportions of some taxa. Characteristics of the oral microbiota are not associated with most measures of oral health.