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Pancreatic Neoplasms: HELP
Articles by Daria Carmela Loconte
Based on 1 article published since 2010
(Why 1 article?)

Between 2010 and 2020, Daria Carmela Loconte wrote the following article about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Article Cancer risk associated with STK11/LKB1 germline mutations in Peutz-Jeghers syndrome patients: results of an Italian multicenter study. 2013

Resta, Nicoletta / Pierannunzio, Daniela / Lenato, Gennaro Mariano / Stella, Alessandro / Capocaccia, Riccardo / Bagnulo, Rosanna / Lastella, Patrizia / Susca, Francesco Claudio / Bozzao, Cristina / Loconte, Daria Carmela / SabbĂ , Carlo / Urso, Emanuele / Sala, Paola / Fornasarig, Mara / Grammatico, Paola / Piepoli, Ada / Host, Cristina / Turchetti, Daniela / Viel, Alessandra / Memo, Luigi / Giunti, Laura / Stigliano, Vittoria / Varesco, Liliana / Bertario, Lucio / Genuardi, Maurizio / Lucci Cordisco, Emanuela / Tibiletti, Maria Grazia / Di Gregorio, Carmela / Andriulli, Angelo / Ponz de Leon, Maurizio / Anonymous3110750. ·Department of Biomedical Sciences and Human Oncology, Medical Genetics Unit, Aldo Moro, University of Bari, Italy. nicoletta.resta@uniba.it ·Dig Liver Dis · Pubmed #23415580.

ABSTRACT: BACKGROUND: Germline mutations in the STK11/LKB1 gene cause Peutz-Jeghers syndrome, an autosomal-dominantly inherited condition characterized by mucocutaneous pigmentation, hamartomatous gastrointestinal polyposis, and an increased risk for various malignancies. We here report the results of the first Italian collaborative study on Peutz-Jeghers syndrome. AIMS: To assess cancer risks in a large homogenous cohort of patients with Peutz-Jeghers syndrome, carrying, in large majority, an identified STK11/LKB1 mutation. METHODS: One-hundred and nineteen patients with Peutz-Jeghers syndrome, ascertained in sixteen different Italian centres, were enrolled in a retrospective cohort study. Relative and cumulative cancer risks and genotype-phenotype correlations were evaluated. RESULTS: 36 malignant tumours were found in 31/119 (29 STK11/LKB1 mutation carriers) patients. The mean age at first cancer diagnosis was 41 years. The relative overall cancer risk was 15.1 with a significantly higher risk (p < 0.001) in females (22.0) than in males (8.6). Highly increased relative risks were present for gastrointestinal (126.2) and gynaecological cancers (27.7), in particular for pancreatic (139.7) and cervical cancer (55.6). The Kaplan-Meier estimates for overall cumulative cancer risks were 20%, 43%, 71%, and 89%, at age 40, 50, 60 and 65 years, respectively. CONCLUSION: Peutz-Jeghers syndrome entails markedly elevated cancer risks, mainly for pancreatic and cervical cancers. This study provides a helpful reference for improving current surveillance protocols.