Pick Topic
Review Topic
List Experts
Examine Expert
Save Expert
  Site Guide ··   
Pancreatic Neoplasms: HELP
Articles by G. Liu
Based on 2 articles published since 2010
(Why 2 articles?)
||||

Between 2010 and 2020, G. Liu wrote the following 2 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Differential MicroRNA Expression Profiles as Potential Biomarkers for Pancreatic Ductal Adenocarcinoma. 2019

Zhu, Y / Wang, J / Wang, F / Yan, Z / Liu, G / Ma, Y / Zhu, W / Li, Y / Xie, L / Bazhin, A V / Guo, X. ·Department of Oncology, International Joint Laboratory for Cell Medical Engineering of Henan Province, Henan University Huaihe Hospital, Kaifeng, Henan, 475000, P. R. China. celltransplant@163.com. · Department of Oncology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450014, P. R. China. wj68happy@hotmail.com. · Department of Preventive Medicine, Cell Signal Transduction Laboratory, Joint National Laboratory for Antibody Drug Engineering, Institute of Biomedical Informatics, Medical School, Henan University, Kaifeng, Henan, 475004, P. R. China. · Department of Oncology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450014, P. R. China. · College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, Tianjin, 300353, P. R. China. mayonggang@nankai.edu.cn. · Department of Anesthesia, Stanford University, CA 94305, USA. wan.zhu@stanford.edu. · Department of General, Visceral, and Transplantation Surgery, Ludwig-Maximilians-University Munich, Munich, 81377, Germany. alexandr.bazhin@med.uni-muenchen.de. · Department of Preventive Medicine, Cell Signal Transduction Laboratory, Joint National Laboratory for Antibody Drug Engineering, Institute of Biomedical Informatics, Medical School, Henan University, Kaifeng, Henan, 475004, P. R. China. xqguo@henu.edu.cn. ·Biochemistry (Mosc) · Pubmed #31234772.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) remains a clinical challenge due to its poor prognosis. Therefore, the early diagnosis of PDAC is extremely important for achieving a cure. MicroRNAs (miRNAs) could serve as a potential biomarker for the early detection and prognosis of PDAC. In this work we analyzed plasma samples from healthy persons and PDAC patients to assess differential miRNA expression profiles by next generation sequencing technology and bioinformatics analysis. In this way, 165 mature miRNAs were found to be significantly deregulated in the patient group, of which 75 and 90 mature miRNAs were up- and down-regulated compared with healthy individuals, respectively. Furthermore, 1029 novel miRNAs were identified. In conclusion, plasma miRNA expression profiles are different between healthy individuals and patients with PDAC. These data provide a possibility for use of miRNA as diagnostic and prognostic biomarkers of PDAC.

2 Article Serum miR-629 is a novel molecular marker for diagnosis and the prognosis of pancreatic cancer. 2018

Shi, W / Lu, Y / Gong, R / Sun, J-J / Liu, G. ·Department of Hepatopancreatobiliary Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China. Peisw721@163.com. ·Eur Rev Med Pharmacol Sci · Pubmed #30178840.

ABSTRACT: OBJECTIVE: Increasing evidence indicates that dysregulation of miRNAs is involved in tumor progression and development. We aimed to determine potential values of miR-629 as a serum diagnostic and prognostic biomarker in pancreatic cancer (PC). PATIENTS AND METHODS: MiR-629 expression levels in PC tissues and serum were measured by quantitative Real-time reverse transcription-polymerase chain reaction (qRT-PCR). Receiver operating characteristic analysis (ROC) was utilized to assess the predictive power of serum miR-629 for PC. Then, the associations of serum miR-629 expression levels with clinicopathological features and prognosis were evaluated. RESULTS: We found that the expression levels of miR-629 were significantly upregulated in both PC tissues and serum in comparison with matched normal tissues and healthy controls, respectively. Importantly, serum miR-629 could efficiently screen PC patients from healthy controls (AUC=0.765). The diagnosis capability of serum miR-629 was significantly higher than that of CA19-9, and the combination of two molecules had higher diagnosis capacity. Higher expression of serum miR-629 in PC patients was associated with advanced TNM stage (p=0.000) and distant metastasis (p=0.003). Moreover, Kaplan-Meier analysis indicated that patients with high expression of serum miR-629 had significantly shorter overall survival (p=0.0022) and disease-free survival (p=0.0003) than the low expression group. Univariate and multivariate analysis showed that serum miR-629 was a significant and independent prognostic predictor for both overall survival and disease-free survival of PC patients. CONCLUSIONS: This study suggested serum miR-629 may be a potential biomarker for the diagnosis and prognosis of PC.