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Pancreatic Neoplasms: HELP
Articles by Ying-Jie Li
Based on 2 articles published since 2009
(Why 2 articles?)

Between 2009 and 2019, Yingjie Li wrote the following 2 articles about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Article CSN5/Jab1 facilitates non-small cell lung cancer cell growth through stabilizing survivin. 2018

Li, Jie / Li, Yingjie / Wang, Bin / Ma, Yongfu / Chen, Ping. ·Department of Chest Surgery, The General Hospital of the People's Liberation Army, Beijing, China. Electronic address: lijieefy186@163.com. · Department of Cardio-thoracic Surgery, First Affiliated Hospital, General Hospital of the People's Liberation Army, Beijing, China. · Department of Chest Surgery, The General Hospital of the People's Liberation Army, Beijing, China. ·Biochem Biophys Res Commun · Pubmed #29596838.

ABSTRACT: CSN5/JAB1 is a critical subunit of the COP9 signalosome (CSN) and is essentially involved in diverse types of cancer, but little is known about the role of CSN5 in non-small cell lung cancer (NSCLC). In the current study, we found that CSN5 expression was higher in NSCLC tissues compared to the corresponding non-tumor tissues. High CSN5 expression level is closely correlated with tumor progression and poor survival in NSCLC patients. We also found that knockdown of CSN5 remarkably suppressed cell growth by inducing cell cycle arrest and apoptosis promotion in NSCLC cells. Mechanistic investigations revealed that CSN5 directly bound survivin and decreased its ubiquitination to enhance the protein stability of survivin. Additionally, our results confirmed that the tumor-promoting effects of CSN5 in NSCLC cells is at least partly through stabilization of survivin. Overall, our data suggested that CSN5 functions as an oncogenic gene in NSCLC, which could be a potential diagnostic and therapeutic target for NSCLC.

2 Article Management of delayed post-pancreaticoduodenectomy arterial bleeding: interventional radiological treatment first. 2011

Zhang, Ji / Zhu, Xu / Chen, Hui / Qian, Hong-Gang / Leng, Jia-Hua / Qiu, Hui / Wu, Jian-Hui / Liu, Bo-Nan / Liu, Qiao / Lv, Ang / Li, Ying-Jie / Zhou, Guo-Quan / Hao, Chun-Yi. ·Department of Hepatopancreatobiliary Surgery, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, PR China. ·Pancreatology · Pubmed #21968388.

ABSTRACT: OBJECTIVE: To investigate the diagnosis and treatment of delayed post-pancreaticoduodenectomy arterial bleeding (DPPAB). METHODS: Records of 336 patients who underwent pancreaticoduodenectomy (PD) between January 2000 and December 2010 were retrospectively analyzed. Detailed data of patients with DPPAB were assessed by a thorough review of medical records. RESULTS: 14 patients developed DPPAB. The mean time interval between the initial surgery and DPPAB was 33 days (range 7-72). Three patients experienced sentinel bleeding 5-8 days before DPPAB. All DPPAB patients had intra-abdominal septic complications before bleeding. The overall prevalence of success of angiography and transcatheter arterial embolization (TAE) was 85.7% (12/14), including 3 patients who achieved complete hemostasis by TAE after unsuccessful re-laparotomy. The prevalence of mortality of DPPAB was 28.6% (4/14). After hemostasis was achieved, intra-abdominal septic complications were controlled by percutaneous catheter drainage or re-laparotomy with drain replacement. CONCLUSION: Angiography and TAE are recommended as the first-line diagnostic and treatment choice for DPPAB, respectively. Surgical intervention should be preserved to eliminate the cause of bleeding.