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Pancreatic Neoplasms: HELP
Articles by Marco Schiavo Lena
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, Marco Schiavo Lena wrote the following 2 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Review Nerves and Pancreatic Cancer: New Insights into a Dangerous Relationship. 2019

Gasparini, Giulia / Pellegatta, Marta / Crippa, Stefano / Lena, Marco Schiavo / Belfiori, Giulio / Doglioni, Claudio / Taveggia, Carla / Falconi, Massimo. ·Pancreas Translational & Clinical Research Center, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. gasparini.giulia@hsr.it. · Axo-Glial Interaction Unit, INSPE, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. gasparini.giulia@hsr.it. · Axo-Glial Interaction Unit, INSPE, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. pellegatta.marta@hsr.it. · Pancreas Translational & Clinical Research Center, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. crippa1.stefano@hsr.it. · Vita Salute San Raffaele University, 20132 Milan, Italy. crippa1.stefano@hsr.it. · Pathology Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. schiavolena.marco@hsr.it. · Pancreas Translational & Clinical Research Center, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. belfiori.giulio@hsr.it. · Vita Salute San Raffaele University, 20132 Milan, Italy. doglioni.claudio@hsr.it. · Pathology Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. doglioni.claudio@hsr.it. · Axo-Glial Interaction Unit, INSPE, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. taveggia.carla@hsr.it. · Pancreas Translational & Clinical Research Center, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. falconi.massimo@hsr.it. · Vita Salute San Raffaele University, 20132 Milan, Italy. falconi.massimo@hsr.it. ·Cancers (Basel) · Pubmed #31248001.

ABSTRACT: Perineural invasion (PNI) is defined as the presence of neoplastic cells along nerves and/or within the different layers of nervous fibers: epineural, perineural and endoneural spaces. In pancreatic cancer-particularly in pancreatic ductal adenocarcinoma (PDAC)-PNI has a prevalence between 70 and 100%, surpassing any other solid tumor. PNI has been detected in the early stages of pancreatic cancer and has been associated with pain, increased tumor recurrence and diminished overall survival. Such an early, invasive and recurrent phenomenon is probably crucial for tumor growth and metastasis. PNI is a still not a uniformly characterized event; usually it is described only dichotomously ("present" or "absent"). Recently, a more detailed scoring system for PNI has been proposed, though not specific for pancreatic cancer. Previous studies have implicated several molecules and pathways in PNI, among which are secreted neurotrophins, chemokines and inflammatory cells. However, the mechanisms underlying PNI are poorly understood and several aspects are actively being investigated. In this review, we will discuss the main molecules and signaling pathways implicated in PNI and their roles in the PDAC.

2 Article Positive neck margin at frozen section analysis is a significant predictor of tumour recurrence and poor survival after pancreatodudenectomy for pancreatic cancer. 2020

Crippa, Stefano / Guarneri, Giovanni / Belfiori, Giulio / Partelli, Stefano / Pagnanelli, Michele / Gasparini, Giulia / Balzano, Gianpaolo / Lena, Marco Schiavo / Rubini, Corrado / Doglioni, Claudio / Zamboni, Giuseppe / Falconi, Massimo. ·Division of Pancreatic Surgery, Pancreas Translational & Clinical Research Center, Università Vita Salute, IRCCS San Raffaele Scientific Institute, Milan, Italy. · Department of Pathology, Università Vita Salute, IRCCS San Raffaele Scientific Institute, Milan, Italy. · Department of Pathology, Università Politecnica Delle Marche, Ospedali Riuniti, Ancona, Italy. · Department of Pathology, Ospedale Sacro Cuore-Don Calabria, Negrar, Italy. · Division of Pancreatic Surgery, Pancreas Translational & Clinical Research Center, Università Vita Salute, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address: falconi.massimo@hsr.it. ·Eur J Surg Oncol · Pubmed #32098733.

ABSTRACT: BACKGROUND: The possible benefit of frozen section (FS) analysis during (PD) for pancreatic ductal adenocarcinoma (PDAC) and of additional resection up to total pancreatectomy (TP) is debated. Aim of this work is to evaluate the prognostic role of positive FS analysis after PD for PDAC. METHODS: Multicentric retrospective analysis on prospective databases of three institutions. Based on FS analysis patients were classified as FS negative/FS positive. All positive FS patients underwent extended PD (EPD) or TP. Postoperative outcomes, disease-free (DFS) and disease-specific survival (DSS) were evaluated. RESULTS: Of 371 patients, 58 (16%) had positive FS. This resulted in 313 (84%) SPD (standard pancreatoduodenectomy), 22 (6%) EPD and 36 (10%) TP. Postoperative mortality was higher in patients undergoing TP (11% compared to 4.5% in EPD and 1% in SPD; p = 0.01). 26% of patients underwent neoadjuvant therapy, and it did not decrease the rate of positive FS. Systemic/local relapse rates were 59% and 41% in negative FS group, and 78% and 22% in positive FS group (p = 0.031). Median DFS and DSS were 20 and 37 months in negative FS group, and 12 and 23 months in positive FS patients (p = 0.001). Independent predictors of recurrence were G3, N1/N2 status and positive FS. R1 resection, G3, N1/N2 status, perineural invasion and positive FS were independent predictors of DSS. CONCLUSIONS: Positive FS analysis is a poor prognostic factor after PD for PDAC. It is significantly associated with a high rate of R1 resection at final histology, PDAC recurrence and poor survival.