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Pancreatic Neoplasms: HELP
Articles by Alberto Larghi
Based on 33 articles published since 2009
(Why 33 articles?)
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Between 2009 and 2019, A. Larghi wrote the following 33 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
Pages: 1 · 2
26 Article Risk factors for intraductal papillary mucinous neoplasm (IPMN) of the pancreas: a multicentre case-control study. 2013

Capurso, Gabriele / Boccia, Stefania / Salvia, Roberto / Del Chiaro, Marco / Frulloni, Luca / Arcidiacono, Paolo Giorgio / Zerbi, Alessandro / Manta, Raffaele / Fabbri, Carlo / Ventrucci, Maurizio / Tarantino, Ilaria / Piciucchi, Matteo / Carnuccio, Antonella / Boggi, Ugo / Leoncini, Emanuele / Costamagna, Guido / Delle Fave, Gianfranco / Pezzilli, Raffaele / Bassi, Claudio / Larghi, Alberto / Anonymous6710751 / Anonymous6720751. ·Digestive and Liver Disease Unit, Faculty of Medicine and Psychology, Sapienza University of Rome at S. Andrea Hospital, Rome, Italy. gabriele.capurso@gmail.com ·Am J Gastroenterol · Pubmed #23458848.

ABSTRACT: OBJECTIVES: To investigate environmental, personal, and hereditary risk factors associated with the occurrence of intraductal papillary mucinous neoplasms of the pancreas (IPMNs). METHODS: Multicentre case-control study. Risk factors were identified from a questionnaire collecting data on family and medical history, and environmental factors. Cases were prevalent IPMNs seen at the participating units within an 18-month timeframe. Matched controls were enrolled alongside patients seen at outpatient clinics. RESULTS: Three-hundred and ninety patients with IPMN and 390 matched controls (166 males, mean age 65 in each group) were enrolled. Of the IPMNs, 310 had branch-duct involvement and 80 main-duct involvement. The only cancer with a 1st degree family history significantly higher in IPMN was pancreatic ductal adenocarcinoma (PDAC) (5.4% vs. 1.5%). Previous history of diabetes (13.6% vs. 7.5%), chronic pancreatitis (CP) (3.1% vs. 0.3%), peptic ulcer (7.2% vs. 4.3%), and insulin use (4.9% vs. 1.1%) were all more frequent with IPMNs. Logistic regression multivariate analysis revealed that history of diabetes (odds ratio (OR): 1.79, confidence interval (CI) 95%: 1.08-2.98), CP (OR: 10.10, CI 95%: 1.30-78.32), and family histories of PDAC (OR: 2.94, CI 95%: 1.17-7.39) were all independent risk factors. However, when analysis was restricted to diabetics who had taken insulin, risk of IPMN became stronger (OR: 6.03, CI 95%: 1.74-20.84). The association with all these risk factors seemed stronger for the subgroup with main duct involvement. CONCLUSIONS: A previous history of diabetes, especially with insulin use, CP, and family history of PDAC are all relevant risk factors for the development of IPMN. These results suggest an overlap between certain risk factors for PDAC and IPMN.

27 Article Endoscopic ultrasound-guided fine-needle aspiration with liquid-based cytologic preparation in the diagnosis of primary pancreatic lymphoma. 2010

Rossi, Esther Diana / Larghi, Alberto / Verna, Elizabeth C / Martini, Maurizio / Galasso, Domenico / Carnuccio, Antonella / Larocca, Luigi Maria / Costamagna, Guido / Fadda, Guido. ·Department of Pathology, Catholic University, Rome, Italy. ·Pancreas · Pubmed #20944491.

ABSTRACT: OBJECTIVES: The diagnosis subtyping of lymphoma on specimens collected by endoscopic ultrasound fine-needle aspiration (EUS-FNA) can be extremely difficult. When a cytopathologist is available for the on-site evaluation, the diagnosis may be achieved by applying flow cytometric techniques. We describe our experience with immunocytochemistry (ICC) and molecular biology studies applied on EUS-FNA specimens processed with a liquid-based cytologic (LBC) preparation for the diagnosis of primary pancreatic lymphoma (PPL). METHODS: Three patients with a pancreatic mass underwent EUS-FNA. The collected specimens were processed with the ThinPrep method for the cytologic diagnosis and eventual additional investigations. RESULTS: A morphologic picture consistent with PPL was found on the LBC specimens of the 3 patients. Subsequent ICC and molecular biology studies for immunoglobulin heavy chain gene rearrangement established the diagnosis of pancreatic large B-cell non-Hodgkin lymphoma in 2 patients and a non-Hodgkin lymphoma with plasmoblastic/immunoblastic differentiation in the remaining one. CONCLUSIONS: An LBC preparation can be used to diagnose and subtype PPL by applying ICC and molecular biology techniques to specimens collected with EUS-FNA. This method can be an additional processing method for EUS-FNA specimens in centers where on-site cytopathologist expertise is not available.

28 Article Concomitant intraductal papillary mucinous neoplasm and pancreatic endocrine tumour: Report of two cases and review of the literature. 2009

Larghi, A / Stobinski, M / Galasso, D / Lecca, P G / Costamagna, G. ·Digestive Endoscopy Unit, Catholic University, Rome, Italy. albertolarghi@yahoo.it ·Dig Liver Dis · Pubmed #19223252.

ABSTRACT: It has been suggested that the occurrence of intraductal papillary mucinous neoplasms in association with pancreatic endocrine tumours is more frequent than expected [Goh BK, Ooi LL, Kumarasinghe MP, Tan YM, Cheow PC, Chow PK, et al. Clinicopathological features of patients with concomitant intraductal papillary mucinous neoplasm of the pancreas and pancreatic endocrine neoplasm. Pancreatology 2006;6:520-6]. Up to now, 10 patients with concomitant intraductal papillary mucinous neoplasms and pancreatic endocrine tumours have been reported [Goh BK, Ooi LL, Kumarasinghe MP, Tan YM, Cheow PC, Chow PK, et al. Clinicopathological features of patients with concomitant intraductal papillary mucinous neoplasm of the pancreas and pancreatic endocrine neoplasm. Pancreatology 2006;6:520-6; Zhao X, Stabile BE, Mo J, Wang J, French SW. Nesidioblastosis coexisting with islet cell tumor and intraductal papillary mucinous hyperplasia. Arch Pathol Lab Med 2001;125:1344-7; Marrache F, Cazals-Hatem D, Kianmanesh R, Palazzo L, Couvelard A, O'Toole D, et al. Endocrine tumor and intraductal papillary mucinous neoplasm of the pancreas: a fortuitous association? Pancreas 2005;31:79-83]. In most cases the synchronous existence of both tumours was incidentally discovered after the examination of the surgical specimen. We report two additional patients with intraductal papillary mucinous neoplasms and pancreatic endocrine tumours, in whom both tumours were diagnosed before surgery.

29 Minor EUS-guided radiofrequency ablation of the celiac axis in pancreatic cancer: Is money worth the pain? 2019

Larghi, Alberto / Rimbaş, Mihai / Crinò, Stefano Francesco. ·Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy. · IRCCS, Fondazione Policlinico Universitario A. Gemelli, CERTT, Center for Endoscopic Research Therapeutics and Training, Catholic University, Rome, Italy; Departments of Gastroenterology and Internal Medicine, Colentina Clinical Hospital, Carol Davila University of Medicine, Bucharest, Romania. · Pancreas Institute, Gastroenterology and Digestive Endoscopy Unit, University Hospital Azienda Ospedaliera Universitaria Integrata, Verona, Italy. ·Gastrointest Endosc · Pubmed #30567682.

ABSTRACT: -- No abstract --

30 Minor Endoscopic ultrasonography-guided ethanol-lipiodol ablation of small neuroendocrine tumors: What volume should we inject? 2018

Rimbaş, Mihai / Larghi, Alberto. ·Digestive Endoscopy Unit, Fondazione Policlinico A. Gemelli, IRCCS, Rome, Italy. · Gastroenterology and Internal Medicine Departments, Colentina Clinical Hospital, Carol Davila University of Medicine, Bucharest, Romania. ·Dig Endosc · Pubmed #29974978.

ABSTRACT: -- No abstract --

31 Minor Response to Kawakubo et al. 2014

Capurso, Gabriele / Boccia, Stefania / Larghi, Alberto. ·Digestive and Liver Disease Unit, Sapienza University of Rome at S. Andrea Hospital, Rome, Italy. · Department of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy. · Digestive Endoscopy Unit;, Università Cattolica del Sacro Cuore, Rome, Italy. ·Am J Gastroenterol · Pubmed #24594960.

ABSTRACT: -- No abstract --

32 Minor Masking effect of chronic pancreatitis in the interpretation of somatostatin receptor positron emission tomography in pancreatic neuroendocrine tumors. 2013

Treglia, Giorgio / Farchione, Alessandra / Stefanelli, Antonella / Brizi, Maria Gabriella / Larghi, Alberto / Inzani, Frediano / Rindi, Guido / Rufini, Vittoria. · ·Pancreas · Pubmed #23591437.

ABSTRACT: -- No abstract --

33 Minor Pancreatic metastases from a bronchopulmonary carcinoid diagnosed by endoscopic ultrasonography-guided fine-needle tissue acquisition. 2012

Larghi, Alberto / Lugli, Francesca / Sharma, Vijay / Carnuccio, Antonella / Anastasi, Francesco / Fusco, Alessandra / Perotti, Germano / De Marinis, Laura / Costamagna, Guido / Rindi, Guido. · ·Pancreas · Pubmed #22415675.

ABSTRACT: -- No abstract --

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