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Pancreatic Neoplasms: HELP
Articles by Romaric Lacroix
Based on 1 article published since 2010
(Why 1 article?)
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Between 2010 and 2020, Romaric Lacroix wrote the following article about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Biomarkers for the risk of thrombosis in pancreatic adenocarcinoma are related to cancer process. 2018

Faille, Dorothée / Bourrienne, Marie-Charlotte / de Raucourt, Emmanuelle / de Chaisemartin, Luc / Granger, Vanessa / Lacroix, Romaric / Panicot-Dubois, Laurence / Hammel, Pascal / Lévy, Philippe / Ruszniewski, Philippe / Ajzenberg, Nadine / Rebours, Vinciane. ·Department of Hematology, Bichat Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. · Laboratory for Vascular Translational Science (LVTS), INSERM U1148, University of Paris Diderot, Sorbonne Paris Cité, Paris, France. · Department of Hematology, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris, Clichy, France. · Department of Immunology, Bichat Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. · Inflammation, Chemokines and Immunopathology, INSERM UMR 996, Paris-Sud University, Châtenay-Malabry, France. · Vascular Research Centre of Marseille (VRCM), INSERM UMR 1076, Aix-Marseille University, Marseille, France. · Haematology and Vascular Biology Laboratory, Conception Hospital, Assistance Publique-Hôpitaux de Marseille, Marseille, France. · Digestive Oncology Unit, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris, Clichy, France. · Centre de Recherche sur l'Inflammation (CRI), INSERM UMR 1149, University of Paris Diderot, Sorbonne Paris Cité, Paris, France. · Department of Pancreatology and Gastroenterology, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris, Clichy, France. ·Oncotarget · Pubmed #29899870.

ABSTRACT: Background: Venous thrombo-embolic events (VTE) frequently occur in patients with pancreatic ductal adenocarcinoma (PDAC) and contribute to high morbidity and mortality. Objectives: To determine whether VTE biomarkers are related to cancer, inflammation or precancerous states and to assess their relevance to predict VTE in PDAC. Patients and Methods: We compared VTE biomarkers in patients with PDAC ( Results: Factor VIII, D-dimers, von Willebrand factor, free tissue factor pathway inhibitor and microvesicle-tissue factor (MV-TF) activity were higher in PDAC patients compared to patients with IPMN or chronic pancreatitis. PDAC patients with metastasis presented higher D-dimers and MV-TF activity compared to patients with localized lesions, but elevation of D-dimers was dependent on tumor size. In multivariate analysis, elevated D-dimers (≥2.16 µg/mL) or MV-TF activity (≥2.37 pg/mL) were significant risk factors for VTE in PDAC patients, after adjustment for age and sex (HR 4.9 [1.0-23.1] or HR 10.5 [1.5-72.4], mean [interquartile range], respectively). Cumulative probability of VTE at 6 months was higher in patients with elevated D-dimers (56.3% vs 15.6%, Conclusions: VTE biomarkers including D-dimers and MV-TF activity are not related to inflammation but rather to cancer process and dissemination. D-dimers and MV-TF activity are associated to future VTE in PDAC patients and could help identify patients who could benefit from thromboprophylaxis.