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Pancreatic Neoplasms: HELP
Articles by Teresa S. Kim
Based on 2 articles published since 2010
(Why 2 articles?)

Between 2010 and 2020, Teresa S. Kim wrote the following 2 articles about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Review Diagnosis and Management of Pancreatic Cystic Neoplasms. 2015

Kim, Teresa S / Fernandez-del Castillo, Carlos. ·Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, GRB-425, Boston, MA 02114, USA. · Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, WAC-460, Boston, MA 02114, USA. Electronic address: cfernandez@partners.org. ·Hematol Oncol Clin North Am · Pubmed #26226903.

ABSTRACT: Incidentally discovered pancreatic cystic lesions are increasingly common, affecting up to 10% to 15% of patients undergoing cross-sectional imaging. Although some pancreatic cystic neoplasms harbor invasive malignancy or the potential to progress over time, a majority are benign and can be observed safely. Accurate diagnosis is key to appropriate management. Diagnosis requires a multidisciplinary and multimodal approach. This review discusses each type of pancreatic cystic neoplasm and the current data on diagnosis and treatment.

2 Article Mobilization of CD8 2019

Seo, Yongwoo David / Jiang, Xiuyun / Sullivan, Kevin M / Jalikis, Florencia G / Smythe, Kimberly S / Abbasi, Arezou / Vignali, Marissa / Park, James O / Daniel, Sara K / Pollack, Seth M / Kim, Teresa S / Yeung, Raymond / Crispe, Ian Nicholas / Pierce, Robert H / Robins, Harlan / Pillarisetty, Venu G. ·Department of Surgery, University of Washington, Seattle, Washington. · Department of Pathology, University of Washington, Seattle, Washington. · Fred Hutchinson Cancer Research Center, Seattle, Washington. · Adaptive Biotechnologies, Seattle, Washington. · Department of Surgery, University of Washington, Seattle, Washington. vgp@uw.edu. ·Clin Cancer Res · Pubmed #30940657.

ABSTRACT: PURPOSE: Pancreatic ductal adenocarcinoma (PDA) is rarely cured, and single-agent immune checkpoint inhibition has not demonstrated clinical benefit despite the presence of large numbers of CD8 EXPERIMENTAL DESIGN: Preserved human PDA specimens were analyzed using multiplex IHC (mIHC) and T-cell receptor (TCR) sequencing. Fresh tumor was treated in organotypic slice culture to test the effects of combination PD-1 and CXCR4 blockade. Slices were analyzed using IHC, flow cytometry, and live fluorescent microscopy to assess tumor kill, in addition to T-cell expansion and mobilization. RESULTS: mIHC demonstrated fewer CD8 CONCLUSIONS: Endogenous tumor-reactive T cells are present within the human PDA tumor microenvironment and can be reactivated by combined blockade of PD-1 and CXCR4. This provides a new basis for the rational selection of combination immunotherapy for PDA.