Pick Topic
Review Topic
List Experts
Examine Expert
Save Expert
  Site Guide ··   
Pancreatic Neoplasms: HELP
Articles by Igor E. Khatkov
Based on 5 articles published since 2010
(Why 5 articles?)
||||

Between 2010 and 2020, Igor Khatkov wrote the following 5 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA): A Pan-European Propensity Score Matched Study. 2019

van Hilst, Jony / de Rooij, Thijs / Klompmaker, Sjors / Rawashdeh, Majd / Aleotti, Francesca / Al-Sarireh, Bilal / Alseidi, Adnan / Ateeb, Zeeshan / Balzano, Gianpaolo / Berrevoet, Frederik / Björnsson, Bergthor / Boggi, Ugo / Busch, Olivier R / Butturini, Giovanni / Casadei, Riccardo / Del Chiaro, Marco / Chikhladze, Sophia / Cipriani, Federica / van Dam, Ronald / Damoli, Isacco / van Dieren, Susan / Dokmak, Safi / Edwin, Bjørn / van Eijck, Casper / Fabre, Jean-Marie / Falconi, Massimo / Farges, Olivier / Fernández-Cruz, Laureano / Forgione, Antonello / Frigerio, Isabella / Fuks, David / Gavazzi, Francesca / Gayet, Brice / Giardino, Alessandro / Groot Koerkamp, Bas / Hackert, Thilo / Hassenpflug, Matthias / Kabir, Irfan / Keck, Tobias / Khatkov, Igor / Kusar, Masa / Lombardo, Carlo / Marchegiani, Giovanni / Marshall, Ryne / Menon, Krish V / Montorsi, Marco / Orville, Marion / de Pastena, Matteo / Pietrabissa, Andrea / Poves, Ignaci / Primrose, John / Pugliese, Raffaele / Ricci, Claudio / Roberts, Keith / Røsok, Bård / Sahakyan, Mushegh A / Sánchez-Cabús, Santiago / Sandström, Per / Scovel, Lauren / Solaini, Leonardo / Soonawalla, Zahir / Souche, F Régis / Sutcliffe, Robert P / Tiberio, Guido A / Tomazic, Aleš / Troisi, Roberto / Wellner, Ulrich / White, Steven / Wittel, Uwe A / Zerbi, Alessandro / Bassi, Claudio / Besselink, Marc G / Abu Hilal, Mohammed / Anonymous5620925. ·Department of Surgery, Cancer Center Amsterdam, Academic Medical Center, Amsterdam, the Netherlands. · Department of Surgery, Southampton University Hospital NHS Foundation Trust, Southampton, United Kingdom. · Department of Surgery, San Raffaele Hospital, Milan, Italy. · Department of Surgery, Morriston Hospital, Swansea, United Kingdom. · Department of Surgery, Virginia Mason Medical Center, Seattle, United States. · Department of Surgery, Karolinska Institute, Stockholm, Sweden. · Department of General and HPB surgery and liver transplantation, Ghent University Hospital, Ghent, Belgium. · Department of Surgery, Linköping University, Linköping, Sweden. · Department of Surgery, Universitá di Pisa, Pisa, Italy. · Department of Surgery, Pederzoli Hospital, Peschiera, Italy. · Department of Surgery, S. Orsola-Malpighi Hospital, Bologna, Italy. · Department of Surgery, Universitätsklinikum Freiburg, Freiburg, Germany. · Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands. · Department of Surgery, Pancreas Institute, Verona University Hospital, Verona, Italy. · Department of Surgery, Hospital of Beaujon, Clichy, France. · Department of Surgery, Oslo University Hospital and Institute for Clinical Medicine, Oslo, Norway. · Department of Surgery, Erasmus MC, Rotterdam, the Netherlands. · Department of Surgery, Hopital Saint Eloi, Montpellier, France. · Department of Surgery, Hospital Clínic de Barcelona, Barcelona, Spain. · Department of Surgery, Niguarda Ca' Granda Hospital, Milan, Italy. · Department of Surgery, Institut Mutualiste Montsouris, Paris, France. · Department of Surgery, Humanitas University Hospital, Milan, Italy. · Department of Surgery, Heidelberg University Hospital, Heidelberg, Germany. · Department of Surgery, Oxford University Hospital NHS Foundation Trust, Oxford, United Kingdom. · Clinic for Surgery, UKSH Campus Lübeck, Lübeck, Germany. · Department of Surgery, Moscow Clinical Scientific Center, Moscow, Russian Federation. · Department of Surgery, University Medical Center Ljubljana, Ljubljana, Slovenia. · Department of Surgery, King's College Hospital NHS Foundation Trust, London, United Kingdom. · Department of Surgery, University hospital Pavia, Pavia, Italy. · Department of Surgery, Hospital del Mar, Barcelona, Spain. · Department of Surgery, University Hospital Birmingham, Birmingham, United Kingdom. · Surgical Clinic, Department of clinical and experimental sciences, University of Brescia, Brescia, Italy. · Department of Surgery, The Freeman Hospital Newcastle Upon Tyne, Newcastle, United Kingdom. ·Ann Surg · Pubmed #29099399.

ABSTRACT: OBJECTIVE: The aim of this study was to compare oncological outcomes after minimally invasive distal pancreatectomy (MIDP) with open distal pancreatectomy (ODP) in patients with pancreatic ductal adenocarcinoma (PDAC). BACKGROUND: Cohort studies have suggested superior short-term outcomes of MIDP vs. ODP. Recent international surveys, however, revealed that surgeons have concerns about the oncological outcomes of MIDP for PDAC. METHODS: This is a pan-European propensity score matched study including patients who underwent MIDP (laparoscopic or robot-assisted) or ODP for PDAC between January 1, 2007 and July 1, 2015. MIDP patients were matched to ODP patients in a 1:1 ratio. Main outcomes were radical (R0) resection, lymph node retrieval, and survival. RESULTS: In total, 1212 patients were included from 34 centers in 11 countries. Of 356 (29%) MIDP patients, 340 could be matched. After matching, the MIDP conversion rate was 19% (n = 62). Median blood loss [200 mL (60-400) vs 300 mL (150-500), P = 0.001] and hospital stay [8 (6-12) vs 9 (7-14) days, P < 0.001] were lower after MIDP. Clavien-Dindo grade ≥3 complications (18% vs 21%, P = 0.431) and 90-day mortality (2% vs 3%, P > 0.99) were comparable for MIDP and ODP, respectively. R0 resection rate was higher (67% vs 58%, P = 0.019), whereas Gerota's fascia resection (31% vs 60%, P < 0.001) and lymph node retrieval [14 (8-22) vs 22 (14-31), P < 0.001] were lower after MIDP. Median overall survival was 28 [95% confidence interval (CI), 22-34] versus 31 (95% CI, 26-36) months (P = 0.929). CONCLUSIONS: Comparable survival was seen after MIDP and ODP for PDAC, but the opposing differences in R0 resection rate, resection of Gerota's fascia, and lymph node retrieval strengthen the need for a randomized trial to confirm the oncological safety of MIDP.

2 Article International Summit on Laparoscopic Pancreatic Resection (ISLPR) "Coimbatore Summit Statements". 2018

Palanivelu, Chinnusamy / Takaori, Kyoichi / Abu Hilal, Mohammad / Kooby, David A / Wakabayashi, Go / Agarwal, Anil / Berti, Stefano / Besselink, Marc G / Chen, Kuo Hsin / Gumbs, Andrew A / Han, Ho-Seong / Honda, Goro / Khatkov, Igor / Kim, Hong Jin / Li, Jiang Tao / Duy Long, Tran Cong / Machado, Marcel Autran / Matsushita, Akira / Menon, Krish / Min-Hua, Zheng / Nakamura, Masafumi / Nagakawa, Yuichi / Pekolj, Juan / Poves, Ignasi / Rahman, Shahidur / Rong, Liu / Sa Cunha, Antonio / Senthilnathan, Palanisamy / Shrikhande, Shailesh V / Gurumurthy, S Srivatsan / Sup Yoon, Dong / Yoon, Yoo-Seok / Khatri, Vijay P. ·Division of Gastrointestinal Surgery and Minimal Access Surgery, GEM Hospital and Research Centre, Coimbatore, India. Electronic address: palanivelu@mac.com. · Division of Hapato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. · Division of HPB Surgery, Southampton General Hospital (NHS), Southampton, UK. · Department of Surgery, Division of Surgical Oncology, Emory University School of Medicine, Atlanta, United States. · Department of Surgery, Ageo Central General Hospital, Saitama, Japan. · Department of Surgical Gastroenterology, G B Pant Hospital, Delhi, India. · Division of Miniinvasive Surgery, S. Andrea Hospital, La Spezia, Italy. · Hepato-Pancreato- Biliary (HPB) Surgery, Academic Medical Center, Amsterdam, The Netherlands. · Department of Surgery, Far-Eastern Memorial Hospital, Taiwan. · Department of Surgical Oncology, Summit Medical Group-MD Anderson Cancer Center, Berkeley Heights, NJ, USA. · Comprehensive Cancer Center, Seoul National University Bundang Hospital, Bundang, South Korea. · Department of Hepato-Biliary-Pancreatic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan. · Surgical Oncology, Moscow Clinical Scientific Center, Moscow, Russia. · Department of HBP Surgery, Yeungnam University Hospital, Daegu, South Korea. · Department of Surgery, Second Affiliated Hospital, Zhejiang University, Hangzhou, China. · Department of General Surgery, University Medical Center in Ho Chi Minh City Vietnam, Ho Chi Minh, Viet Nam. · Department of Surgery, University of Sao Paulo, Sao Paulo, Brazil. · Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan. · Division and/or Department - Institute of Liver Studies, Department of Liver Transplantation and HPB, King's College Hospital NHS Trust, Camberwell, UK. · Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. · Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. · Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan. · General Surgery Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. · Department of Surgery, Hospital del Mar, Barcelona, Spain. · Hepatobiliary Pancreatic and Liver Transplant Division, Bangobandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. · The Military Institute of Hepato-Pancreatico-Biliary Surgery and Second Department of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital, Beijing, China. · Department of HPB Surgery, AP-HP Hôpital Paul Brousse, Paris, France. · Division of Minimally Invasive, Liver Transplantation & HPB Surgery, GEM Hosptial & Research Centre, Coimbatore, India. · Division of Cancer Surgery / Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India. · Division of HPB & Minimal Access Surgery, GEM Hosptial & Research Centre, Coimbatore, India. · Department of Surgery, Gangnam Severance Hospital, Yonsei University Health System, Seoul, South Korea. · Department of Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea. · Department of Oncology, California Northstate University College of Medicine, Elk Grove, California, USA. ·Surg Oncol · Pubmed #29371066.

ABSTRACT: The International Summit on Laparoscopic Pancreatic Resection (ISLPR) was held in Coimbatore, India, on 7th and 8th of October 2016 and thirty international experts who regularly perform laparoscopic pancreatic resections participated in ISPLR from four continents, i.e., South and North America, Europe and Asia. Prior to ISLPR, the first conversation among the experts was made online on August 26th, 2016 and the structures of ISPLR were developed. The aims of ISPLR were; i) to identify indications and optimal case selection criteria for minimally invasive pancreatic resection (MIPR) in the setting of both benign and malignant diseases; ii) standardization of techniques to increase the safety of MIPR; iii) identification of common problems faced during MIPR and developing associated management strategies; iv) development of clinical protocols to allow early identification of complications and develop the accompanying management plan to minimize morbidity and mortality. As a process for interactive discussion, the experts were requested to complete an online questionnaire consisting of 65 questions about the various technical aspects of laparoscopic pancreatic resections. Two further web-based meetings were conducted prior to ISPLR. Through further discussion during ISPLR, we have created productive statements regarding the topics of Disease, Implementation, Patients, Techniques, and Instrumentations (DIPTI) and hereby publish them as "Coimbatore Summit Statements".

3 Article One hundred and forty five total laparoscopic pancreatoduodenectomies: A single centre experience. 2017

Khatkov, Igor / Izrailov, Roman / Tyutyunnik, Pavel / Khisamov, Artur / Andrianov, Alexey / Fingerhut, Abe. ·Moscow Clinical Scientific Centre, Moscow, Russia; Moscow State University of Medicine and Dentistry, Moscow, Russia. · Moscow Clinical Scientific Centre, Moscow, Russia; Moscow State University of Medicine and Dentistry, Moscow, Russia. Electronic address: tiutiunnikk@gmail.com. · Moscow Clinical Scientific Centre, Moscow, Russia. · Section for Surgical Research, Department of Surgery, Medical University of Graz, Graz, Austria. ·Pancreatology · Pubmed #28867529.

ABSTRACT: INTRODUCTION: Laparoscopic pancreatoduodenectomy (LPD) remains one of the most challenging minimal invasive operations today. PATIENTS AND METHODS: Between January 2007 and December 2016, 197 patients were scheduled for LPD but 162 patients (from January 2007 to July 2016) were analysed in this cohort series. RESULTS: Total LPD concerned for 162 patients (five patients did not undergo PD and 12 underwent conversion): standard LPD in 104 patients (66%), and laparoscopic pylorus-preserving PD in 41 patients (26%). Median operative time was 415 (240-765) min. Median blood loss was 200 (50-2100) ml. Twelve patients required blood transfusion. Clinically relevant pancreatic fistula (ISGPF grades B and C) occurred in 21 (13%) patients: 16 (10.0%) grade B, and 5 (3%) grade C. Grades B and C delayed gastric emptying occurred in five patients each. Grades B and C post-pancreatectomy bleeding occurred in 9 (5.7%) and 3 (1.9%) patients, respectively. LPD was performed for 18 (11.4%) benign and 139 (88.5%) malignant lesions. Superior mesenteric and/or portal vein involvement required major venous resection in eight patients. The 90-day mortality 5.0%. The median overall survival for pancreatic ductal adenocarcinoma was 22.5 months. CONCLUSION: Morbidity and mortality for LPD are comparable to open procedures rates in the literature. Laparoscopic major venous resection is feasible and safe.

4 Article Laparoscopic surgery for pancreatic neoplasms: the European association for endoscopic surgery clinical consensus conference. 2017

Edwin, Bjørn / Sahakyan, Mushegh A / Abu Hilal, Mohammad / Besselink, Marc G / Braga, Marco / Fabre, Jean-Michel / Fernández-Cruz, Laureano / Gayet, Brice / Kim, Song Cheol / Khatkov, Igor E / Anonymous7950896. ·The Intervention Centre, Oslo University Hospital, Rikshospitalet, Oslo, 0027, Norway. · Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway. · Department of Hepato-Pancreato-Billiary Sugery, Oslo University Hospital, Rikshospitalet, Oslo, Norway. · The Intervention Centre, Oslo University Hospital, Rikshospitalet, Oslo, 0027, Norway. sahakyan.mushegh@gmail.com. · Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway. sahakyan.mushegh@gmail.com. · University Hospital Southampton, NHS Foundation Trust, Southampton, UK. · Department of Surgery, Academic Medical Center Amsterdam, Amsterdam, The Netherlands. · Department of Surgery, San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy. · Department of Digestive Surgery, Hospital Saint-Eloi, Montpellier, France. · Department of Surgery, Hospital Clinic, University of Barcelona, Barcelona, Spain. · Department of Digestive Diseases, Institut Mutualiste Montsouris, Université Paris Descartes, Paris, France. · Institut des Systèmes Intelligents et Robotique (ISIR), Université Pierre et Marie Curie, Paris, France. · Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea. · Department of Surgery, Moscow Clinical Scientific Center, Moscow, Russia. · Faculty of Surgery No. 2, Moscow State University of Medicine and Dentistry, Moscow, Russia. ·Surg Endosc · Pubmed #28205034.

ABSTRACT: BACKGROUND: Introduced more than 20 years ago, laparoscopic pancreatic surgery (LAPS) has not reached a uniform acceptance among HPB surgeons. As a result, there is no consensus regarding its use in patients with pancreatic neoplasms. This study, organized by the European Association for Endoscopic Surgery (EAES), aimed to develop consensus statements and clinical recommendations on the application of LAPS in these patients. METHODS: An international panel of experts was selected based on their clinical and scientific expertise in laparoscopic and open pancreatic surgery. Each panelist performed a critical appraisal of the literature and prepared evidence-based statements assessed by other panelists during Delphi process. The statements were further discussed during a one-day face-to-face meeting followed by the second round of Delphi. Modified statements were presented at the plenary session of the 24th International Congress of the EAES in Amsterdam and in a web-based survey. RESULTS: LAPS included laparoscopic distal pancreatectomy (LDP), pancreatoduodenectomy (LPD), enucleation, central pancreatectomy, and ultrasound. In general, LAPS was found to be safe, especially in experienced hands, and also advantageous over an open approach in terms of intraoperative blood loss, postoperative recovery, and quality of life. Eighty-five percent or higher proportion of responders agreed with the majority (69.5%) of statements. However, the evidence is predominantly based on retrospective case-control studies and systematic reviews of these studies, clearly affected by selection bias. Furthermore, no randomized controlled trials (RCTs) have been published to date, although four RCTs are currently underway in Europe. CONCLUSIONS: LAPS is currently in its development and exploration stages, as defined by the international IDEAL framework for surgical innovation. LDP is feasible and safe, performed in many centers, while LPD is limited to few centers. RCTs and registry studies are essential to proceed with the assessment of LAPS.

5 Article Superior mesenteric-portal vein resection during laparoscopic pancreatoduodenectomy. 2017

Khatkov, Igor E / Izrailov, Roman E / Khisamov, Arthur A / Tyutyunnik, Pavel S / Fingerhut, Abraham. ·Department of Surgery, Moscow Clinical Scientific Center, Moscow, Russia. · Chair of Faculty Surgery №2, Moscow State University of Medicine and Dentistry, Moscow, Russia. · Department of Surgery, Moscow Clinical Scientific Center, Moscow, Russia. a.khisamov@mknc.ru. · Section for Surgical Research, Department of Surgery, Medical University of Graz, Graz, Austria. ·Surg Endosc · Pubmed #27444832.

ABSTRACT: BACKGROUND: Laparoscopic pancreatoduodenectomy (LPD) with concomitant resection of major portal vessels has recently emerged as feasible and safe, with similar morbidity and mortality as well as oncologic outcome compared with patients undergoing open PD with major vascular resection. MATERIALS AND METHODS: Of a consecutive series of 133 LPD, eight patients underwent concomitant superior mesenteric vein/portal vein (SMV/PV) resection and reconstruction with the intent of achieving a R0 resection. RESULTS: Four of these eight patients had tangential resection followed by lateral wall repair with Prolene 4.0. One patient had tangential resection with patch reconstruction. Three patients had circular venous resection: One had end-to-end primary venous reconstruction, and two patients had a prosthetic vascular graft interposition. There was no operative mortality. The SMV/PV was patent in all patients postoperatively on ultrasound Doppler or CT scans. Two patients (who underwent circular venous resection) had postoperative complications. One 77-year-old patient with preexisting cardiovascular disease died of heart failure on postoperative day 2, while another (undergoing prosthetic graft reconstruction) had postoperative bilioenteric anastomotic dehiscence and underwent immediate re-laparoscopy for repair. CONCLUSIONS: In our experience, LPD with concomitant major venous resection is feasible even in cases of longitudinal venous invasion. Further studies are needed to evaluate the role of laparoscopy in borderline pancreatic cancer.