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Pancreatic Neoplasms: HELP
Articles by Dimitrios Karavias
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, Dimitrios Karavias wrote the following 2 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Article Statin therapy does not influence the outcome of patients undergoing surgery for pancreatic cancer. 2019

Karavias, Dimitrios / Thomas, Paul / Koh, Amanda / Irving, Glen / Navarro, Alex P / Cameron, Iain C / Gomez, Dhanny / Anonymous4111018. ·Department of Hepatobiliary and Pancreatic Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK. · NIHR Nottingham Digestive Disease Biomedical Research Unit, The University of Nottingham, Nottingham, UK. ·ANZ J Surg · Pubmed #31845479.

ABSTRACT: BACKGROUND: Recently, statins have been associated with improved survival in certain cancers. The aim of this study was to evaluate the impact of statins on the outcome of patients undergoing surgery for pancreatic cancer. In addition, the effect of statins on the histopathological characteristics of the disease was assessed. METHODS: A retrospective review of the prospectively maintained hepato-pancreatico-biliary database was performed and patients with pancreatic cancer who underwent surgery between January 2014 and December 2017 were included. Statistical analysis was performed to assess the impact of statins on histopathological characteristics and survival outcome. RESULTS: A total of 151 patients were included, of whom 71 underwent pancreatic resections and 80 underwent trial dissection and bypass procedures. In the operated group, 20 patients were on statin therapy preoperatively. With respect to disease-free survival, tumour size (P = 0.023) and lymphatic invasion (P = 0.015) were significant variables on univariate analysis. Gender (P = 0.022), adjuvant chemotherapy (P < 0.001), lymphatic invasion (P = 0.021) and tumour size (P = 0.041) were significant variables on univariate analysis with respect to overall survival. Multivariate analysis identified adjuvant chemotherapy as the only independent predictor of overall survival (P < 0.001). No correlations between the use of statins and the histopathological characteristics were identified. CONCLUSION: Adjuvant chemotherapy is an independent predictor of overall survival in patients undergoing surgery for pancreatic cancer. Statin therapy does not influence survival outcomes and histopathological characteristics following surgery for pancreatic cancer.

2 Article Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming. 2019

Koutsioumpa, Marina / Hatziapostolou, Maria / Polytarchou, Christos / Tolosa, Ezequiel J / Almada, Luciana L / Mahurkar-Joshi, Swapna / Williams, Jennifer / Tirado-Rodriguez, Ana Belen / Huerta-Yepez, Sara / Karavias, Dimitrios / Kourea, Helen / Poultsides, George A / Struhl, Kevin / Dawson, David W / Donahue, Timothy R / Fernández-Zapico, Martín E / Iliopoulos, Dimitrios. ·Center for Systems Biomedicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA. · Biological Sciences, University of Southampton, Southampton, UK. · Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK. · Interdisciplinary Biomedical Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK. · Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, Minnesota, USA. · Department of Surgery, Division of General Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA. · Unidad de Investigacion en Enfermedades Oncologicas, Hospital Infantil de Mexico, Mexico City, Mexico. · Department of Pathology, School of Medicine, University of Patras, Patras, Greece. · Department of Surgery, Stanford University School of Medicine, Stanford, California, USA. · Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA. · Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA. ·Gut · Pubmed #30337373.

ABSTRACT: OBJECTIVE: Despite advances in the identification of epigenetic alterations in pancreatic cancer, their biological roles in the pathobiology of this dismal neoplasm remain elusive. Here, we aimed to characterise the functional significance of histone lysine methyltransferases (KMTs) and demethylases (KDMs) in pancreatic tumourigenesis. DESIGN: DNA methylation sequencing and gene expression microarrays were employed to investigate CpG methylation and expression patterns of KMTs and KDMs in pancreatic cancer tissues versus normal tissues. Gene expression was assessed in five cohorts of patients by reverse transcription quantitative-PCR. Molecular analysis and functional assays were conducted in genetically modified cell lines. Cellular metabolic rates were measured using an XF24-3 Analyzer, while quantitative evaluation of lipids was performed by liquid chromatography-mass spectrometry (LC-MS) analysis. Subcutaneous xenograft mouse models were used to evaluate pancreatic tumour growth in vivo. RESULTS: We define a new antitumorous function of the histone lysine (K)-specific methyltransferase 2D (KMT2D) in pancreatic cancer. CONCLUSION: Together our findings define a new tumour suppressor function of KMT2D through the regulation of glucose/fatty acid metabolism in pancreatic cancer.