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Pancreatic Neoplasms: HELP
Articles by Shuichi Kanemitsu
Based on 3 articles published since 2009
(Why 3 articles?)

Between 2009 and 2019, Shuichi Kanemitsu wrote the following 3 articles about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Article [Clinical follow-up of branch duct IPMN]. 2012

Yamaguchi, Koji / Minagawa, Takanori / Kanemitsu, Shuichi / Tamura, Toshinao. ·Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Japan. yamaguchi@med.uoeh-u.ac.jp ·Nihon Shokakibyo Gakkai Zasshi · Pubmed #22306540.

ABSTRACT: -- No abstract --

2 Article Association of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma. 2012

Nagao, Yuichi / Hisaoka, Masanori / Matsuyama, Atsuji / Kanemitsu, Shuichi / Hamada, Tetsuo / Fukuyama, Tokihiko / Nakano, Ryuji / Uchiyama, Akihiko / Kawamoto, Masahiko / Yamaguchi, Koji / Hashimoto, Hiroshi. ·Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. ·Mod Pathol · Pubmed #21983937.

ABSTRACT: Since the discovery of small non-coding RNAs, the analyses of microRNA (miRNA) expression patterns in human cancer have provided new insights into cancer biology. miRNA-21 has been suggested to be one of the miRNAs that have an important role in the development or biological behavior of a variety of malignancies, including pancreatic cancer. This study was conducted to evaluate the relationship between the expression of miRNA-21 and that of its molecular targets, programmed cell death 4 (PDCD4) and tissue inhibitor of metalloproteinase (TIMP3), in pancreatic ductal adenocarcinoma. The study included 65 pancreatic ductal adenocarcinomas and 5 normal pancreatic tissue specimens for comparison. The miRNA expression profiling of five selected pancreatic ductal adenocarcinomas and five normal pancreatic specimens was performed using a microarray platform, and was evaluated by a hierarchical clustering analysis. The miRNA most highly expressed in pancreatic ductal adenocarcinomas (ie, miRNA-21) was further assessed by quantitative real-time reverse transcription PCR (RT-PCR) assays in the 65 pancreatic ductal adenocarcinoma cases. The expression pattern of its molecular targets (eg, PDCD4 and TIMP3) in pancreatic ductal adenocarcinoma was examined immunohistochemically. In the microarray analyses, 28 miRNAs were upregulated in pancreatic ductal adenocarcinoma compared with normal pancreatic tissue, whereas 48 miRNAs were downregulated. miRNA-21 was the most significantly overexpressed miRNA in the pancreatic ductal adenocarcinomas analyzed, and was also highly expressed in 75% of the 65 pancreatic ductal adenocarcinomas examined by real-time RT-PCR. High miRNA-21 expression was correlated with a worse prognosis in the pancreatic ductal adenocarcinoma patients (P=0.045). The immunohistochemical expression patterns of PDCD4 (reduced nuclear staining pattern) and TIMP3 (downregulated expression) were significantly associated with both the upregulated miR-21 expression (P<0.05) and the poor survival of the patients (P<0.001 and P=0.001, respectively). Our data suggest that an overexpression of miRNA-21 is, therefore, associated with the biological behavior of pancreatic ductal adenocarcinoma via the downregulation of the expression of tumor suppressors, PDCD4 and TIMP3, thus resulting in tumor progression and the adverse clinical course of pancreatic ductal adenocarcinoma.

3 Article Pancreatic ductal adenocarcinoma derived from IPMN and pancreatic ductal adenocarcinoma concomitant with IPMN. 2011

Yamaguchi, Koji / Kanemitsu, Shuichi / Hatori, Takashi / Maguchi, Hiroyuki / Shimizu, Yasuhiro / Tada, Minoru / Nakagohri, Toshio / Hanada, Keiji / Osanai, Manabu / Noda, Yutaka / Nakaizumi, Akihiko / Furukawa, Toru / Ban, Shinichi / Nobukawa, Bunsei / Kato, Yo / Tanaka, Masao. ·Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. yamaguch@med.uoeh-u.ac.jp ·Pancreas · Pubmed #21499212.

ABSTRACT: OBJECTIVES: Pancreatic ductal adenocarcinoma (PDAC) may derive from an intraductal papillary mucinous neoplasm (IPMN) of the pancreas or may develop in the pancreatic duct apart from IPMN. The purpose of this study was to define the clinicopathological features of these 2 entities and compare them with those of ordinary PDAC. METHODS: Of 765 patients who had surgical resection for IPMN, 122 were diagnosed as having PDAC derived from IPMN and 31 with PDAC concomitant with IPMN. In addition, 7605 patients with PDAC who were registered in the Japan Pancreas Society pancreatic cancer registry were compared with the above patients. RESULTS: Pancreatic ductal adenocarcinomas derived from IPMN and concomitant with IPMN were significantly smaller, less invasive, and less extensive than ordinary PDAC. The median survival of patients with the 2 conditions was significantly longer than for those with ordinary PDAC when compared overall or when limited to TS2 (2.0 cm < tumor size ≤ 4.0 cm) or TS3 (4.0 cm < tumor size ≤ 6.0 cm) cases. CONCLUSIONS: These findings suggest that PDAC concomitant with IPMN and PDAC derived from IPMN may have more favorable biological behaviors or be diagnosed earlier than ordinary PDAC.