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Pancreatic Neoplasms: HELP
Articles by Ryosuke Itai
Based on 2 articles published since 2010
(Why 2 articles?)

Between 2010 and 2020, Ryosuke Itai wrote the following 2 articles about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Article [Diagnostic utility of endoscopic ultrasonography elastography and contrast-enhanced harmonic endoscopic ultrasonography in a patient with type 2 autoimmune pancreatitis]. 2018

Yokode, Masataka / Shiomi, Hideyuki / Itai, Ryosuke / Mikami, Sakae / Yamashita, Yukimasa / Nakano, Ryota / Ezaki, Takeshi / Masuda, Atsuhiro / Zen, Yoh. ·Department of Gastroenterology, Kobe City Medical Center West Hospital. · Department of Gastroenterology, Kobe University Graduate School of Medicine. · Department of Diagnostic Pathology, Kobe University Graduate School of Medicine. ·Nihon Shokakibyo Gakkai Zasshi · Pubmed #29887592.

ABSTRACT: A referring hospital diagnosed a 57-year-old man with a pancreatic head mass. The initial endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) was inconclusive because of the small sample size. Endoscopic ultrasonography elastography (EUS-EG) and contrast-enhanced harmonic endoscopic ultrasonography (CE-EUS), conducted at our institute, raised the possibility of mass-forming pancreatitis or autoimmune pancreatitis (AIP). A repeat EUS-FNA revealed inflammatory changes, including a neutrophilic duct injury suggestive of type 2 AIP. The pancreatic lesion responded well to the steroid therapy. The present case suggests that EUS-EG and CE-EUS may be useful for diagnostic exclusion of pancreatic cancers, and the combined use of EUS-EG and CE-EUS, with EUS-FNA, may help characterize inflammatory pancreatic lesions.

2 Article A case report of mixed acinar-endocrine carcinoma of the pancreas treated with S-1 chemotherapy: Does it work or induce endocrine differentiation? 2017

Yokode, Masataka / Itai, Ryosuke / Yamashita, Yukimasa / Zen, Yoh. ·aDepartment of Gastroenterology and Hepatology, Kobe City Medical Center West Hospital bDepartment of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. ·Medicine (Baltimore) · Pubmed #29137060.

ABSTRACT: RATIONALE: Acinar cell carcinomas (ACCs) and mixed acinar-endocrine carcinomas (MAECs) of the pancreas are rare, accounting for only 1% of pancreatic tumors. Although both typically present at an advanced stage, chemotherapeutic regimes have not yet been standardized. PATIENT CONCERNS: A 65-year-old man presented with a large mass in the pancreatic tail with multiple liver metastases. DIAGNOSIS, INTERVENTIONS, OUTCOMES: He was initially treated with gemcitabine for suspected ductal carcinoma of the pancreas, but no response was observed. S-1, administered as second-line chemotherapy, showed an approximately 38% reduction in the size of the primary tumor and metastatic deposits with therapeutic effects being maintained for 12 months. When the tumor progressed again, he underwent a percutaneous liver biopsy, which led to the diagnosis of MAEC. Combination therapy with cisplatin and etoposide targeting the endocrine component was administered, and this was based on the endocrine component potentially being less sensitive to S-1 than the ACC element. However, therapy was stopped due to the development of neutropenia, and the patient is currently receiving best supportive care. LESSONS: Given the previous studies suggested that S-1 is more effective for ACCs than gemcitabine, MAECs may also respond to S-1 chemotherapy, similar to ACCs. Another potential interpretation is that S-1 was effective when the condition was ACC, and eventually showed decreased effectiveness when the condition shifted to MAEC. Future studies are needed to conclude whether S-1 chemotherapy truly works against MAECs or induces endocrine differentiation in ACCs as a part of the drug-resistance process.