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Pancreatic Neoplasms: HELP
Articles by Marcello Ingrosso
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, Marcello Ingrosso wrote the following 2 articles about Pancreatic Neoplasms.
 
+ Citations + Abstracts
1 Clinical Trial Capecitabine based postoperative accelerated chemoradiation of pancreatic carcinoma. A dose-escalation study. 2010

Morganti, Alessio G / Picardi, Vincenzo / Ippolito, Edy / Massaccesi, Mariangela / Macchia, Gabriella / Deodato, Francesco / Mattiucci, Gian Carlo / Caravatta, Luciana / Di Lullo, Liberato / Giglio, Gianfranco / Tambaro, Rosa / Mignogna, Samantha / Caprino, Paola / Ingrosso, Marcello / Sofo, Luigi / Cellini, Numa / Valentini, Vincenzo. ·Radiotherapy Unit, Department of Oncology, John Paul II Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy. ·Acta Oncol · Pubmed #20397772.

ABSTRACT: MATERIAL AND METHODS: Patients with resected pancreatic carcinoma were eligible for this study. Capecitabine was administered at a daily dose of 1600 mg/m (2). Regional lymph nodes received a total radiation dose of 45 Gy with 1.8 Gy per fractions. The starting radiation dose to the tumor bed was 50.0 Gy (2.0 Gy/fraction, 25 fractions). Escalation was achieved up to a total dose of 55.0 Gy by increasing the fraction size by 0.2 Gy (2.2 Gy/fraction), while keeping the duration of radiotherapy to five weeks (25 fractions). A concomitant boost technique was used. Dose limiting toxicity (DLT) was defined as any grade>3 hematologic toxicity, grade>2 liver, renal, neurologic, gastrointestinal, or skin toxicity, by RTOG criteria, or any toxicity producing prolonged (> 10 days) radiotherapy interruption. RESULTS AND DISCUSSION: Twelve patients entered the study (median age: 64 years). In the first cohort (six patients), no patient experienced DLT. Similarly in the second cohort, no DLT occurred. All 12 patients completed the planned regimen of therapy. Nine patients experienced grade 1-2 nausea and/or vomiting. Grade 2 hematological toxicity occurred in four patients. The results of our study indicate that a total radiation dose up to 55.0 Gy/5 weeks can be safely administered to the tumor bed, concurrently with capecitabine (1600 mg/m (2)) in patients with resected pancreatic carcinoma.

2 Article Diffuse intestinal pneumatosis after an Endoscopic Retrograde Cholangiopancreatography: A paradigmatic case for an old pathogenetic dilemma. 2016

Festa, Stefano / Spera, Gianluca / Pierro, Antonio / Ingrosso, Marcello. ·Digestive Endoscopy Unit, Fondazione di Ricerca e Cura Giovanni Paolo II, Universit√† Cattolica del Sacro Cuore, Campobasso, Italy. Electronic address: festa.stefano@gmail.com. · Digestive Endoscopy Unit, Fondazione di Ricerca e Cura Giovanni Paolo II, Universit√† Cattolica del Sacro Cuore, Campobasso, Italy. · Radiology Unit, Fondazione di Ricerca e Cura Giovanni Paolo II, Universit√† Cattolica del Sacro Cuore, Campobasso, Italy. ·Dig Liver Dis · Pubmed #26971971.

ABSTRACT: -- No abstract --