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Pancreatic Neoplasms: HELP
Articles by Tsunekazu Hishima
Based on 3 articles published since 2010
(Why 3 articles?)

Between 2010 and 2020, Tsunekazu Hishima wrote the following 3 articles about Pancreatic Neoplasms.
+ Citations + Abstracts
1 Review Calcified liver metastases from a non-functioning pancreatic neuroendocrine tumor. 2014

Kawamoto, Terufumi / Hishima, Tsunekazu / Kimura, Kiminori. ·Division of Hepatology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, 18-22-3 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan, teru19@gmail.com. ·Clin J Gastroenterol · Pubmed #26184029.

ABSTRACT: Neuroendocrine tumors consist of a spectrum of malignancies that arise from neuroendocrine cells throughout the body. Pancreatic neuroendocrine tumors are rare tumors, with an incidence of 3.65 per 100,000 individuals per year, and they account for 1-2 % of all pancreatic neoplasms. A non-functioning pancreatic neuroendocrine tumor with multiple liver metastases with calcifications was diagnosed in a 43-year-old female with diabetes mellitus. Early phase-enhanced computed tomography (CT) showed a hypovascular mass in the pancreatic body and tail with calcifications and multiple liver metastatic masses with calcifications. Percutaneous liver biopsy showed homogenous nuclear chromatins and tumor cells with acidophilic cytoplasm against the hyaline interstitium, and a non-functioning pancreatic neuroendocrine tumor was diagnosed. An interesting clinical image of a metastasis from a pancreatic neuroendocrine tumor is presented in which multiple liver tumors were accompanied by dystrophic calcifications. CT and percutaneous liver biopsy play an important role in the diagnosis of a non-functioning pancreatic neuroendocrine tumor, and are valuable diagnostic methods in planning treatment.

2 Article Intraductal papillary mucinous neoplasm of the pancreas and IgG4-related disease: a coincidental association. 2013

Tabata, Taku / Kamisawa, Terumi / Hara, Seiichi / Kuruma, Sawako / Chiba, Kazuro / Kuwata, Go / Fujiwara, Takashi / Egashira, Hideto / Koizumi, Satomi / Endo, Yuka / Koizumi, Koichi / Fujiwara, Junko / Arakawa, Takeo / Momma, Kumiko / Horiguchi, Shinichiro / Hishima, Tsunekazu / Kurata, Masanao / Honda, Goro / Kloppel, Gunter. ·Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan. ·Pancreatology · Pubmed #23890136.

ABSTRACT: BACKGROUND/AIMS: Coexistence of autoimmune pancreatitis (AIP) and pancreatic cancer, elevation of serum IgG4 levels in pancreatic cancer patients, and infiltration of IgG4-positive plasma cells in peritumorous pancreatitis have been described in a few reports. This study examined the relationship between intraductal papillary mucinous neoplasm (IPMN) of the pancreas and peritumorous IgG4-positive lymphoplasmacytic infiltrates. METHODS: Serum IgG4 levels were measured in 54 patients with IPMN (median 70 years, 26 males and 28 females; 13 main duct type and 41 branch duct type). Histological findings focusing on dense lymphoplasmacytic infiltration, storiform fibrosis, and obliterative phlebitis were reviewed, and immunostaining with IgG4 and IgG was performed in 23 surgically resected IPMN cases (18 main duct type and 5 branch duct type). The presence of IgG4-positive plasma cells >10/hpf and an IgG4-positive/IgG-positive plasma cell ratio >40% were considered significant. RESULTS: Serum IgG4 levels were elevated in 2 (4%) IPMN patients. Significant infiltration of IgG4-positive plasma cells was detected in 4 IPMN cases (17%). The IgG4-positive/IgG-positive plasma cell ratio was >40% in all 4 cases. In one case with a markedly elevated serum IgG4 level (624 mg/dL), typical lymphoplasmacytic sclerosing pancreatitis (AIP type 1) lesions surrounded the whole IPMN. In the 3 other cases, infiltration of IgG4-positive plasma cells with fibrosis was focally detected mainly in the periductal area around the IPMN. CONCLUSIONS: In a few patients with IPMNs, IgG4-positive plasma cell infiltration can occur in the peritumorous area. The association of an IPMN with AIP type 1-like changes seems to be exceptional and coincidental.

3 Minor Pancreatic cancer as the fourth cancer in a patient with Peutz-Jeghers syndrome and a history of familial pancreatic cancer. 2011

Tokura, Michiyo / Kamisawa, Terumi / Kuwata, Go / Koizumi, Koichi / Kurata, Masanao / Hishima, Tsunekazu. · ·Pancreas · Pubmed #21160382.

ABSTRACT: -- No abstract --